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Take measures to expand the soybean planting area to 140 million mu and increase the production capacity steadily.

  CCTV News:Soybean is the main source of edible vegetable oil and protein feed, and it is also an agricultural product with high dependence on foreign countries in China. This year, the state has taken various measures to expand the soybean planting area nationwide to more than 140 million mu.

  This year, the northeast of China has guided farmers to grow more soybeans by carrying out grain-soybean rotation. This year, Heilongjiang Province will co-ordinate 1 billion yuan of agriculture-related funds to support the expansion of more than 10 million mu of soybeans, with the largest area. Jilin Province mobilized farmers’ enthusiasm by means of preferential policies and increasing investment in science and technology. This year, the area of soybean planting was 854,000 mu, up 22% year-on-year.

  In addition, this year, the country promoted soybean and corn strip compound planting in suitable areas such as northwest, Huang-Huai-Hai, southwest and Yangtze River basin. In order to arouse farmers’ enthusiasm, on the basis of the central government subsidizing 150 yuan per mu, the provincial finance will subsidize 170 yuan per mu to make up for the increased costs of sowing, fertilizing, spraying and harvesting. Shaanxi province has sown 1.877 million mu of soybeans and interplanted 680,000 mu of soybeans and corn. Yan ‘an and Yulin have integrated improved varieties, agricultural machinery and processing to increase production, and created 40 soybean-corn strip compound planting demonstration zones.

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Strive to improve the agricultural competitiveness of China’s big countries

The Central Committee of the Communist Party of China’s Proposal on Formulating the Thirteenth Five-year Plan for National Economic and Social Development (hereinafter referred to as the "Proposal") adopted by the Fifth Plenary Session of the 18th CPC Central Committee puts forward that "improving the quality, efficiency and competitiveness of agriculture". China is a big agricultural country, and China’s agriculture is a big country agriculture. During the Thirteenth Five-Year Plan period, only by accelerating the development of modern agriculture and striving to improve the agricultural competitiveness of China’s big countries can we provide a solid foundation and strong guarantee for the transformation and upgrading of economic development and the building of a well-off society in an all-round way. Accelerating the development of modern agriculture and striving to improve agricultural competitiveness are also the needs to cope with the profound changes in the domestic and international environment for agricultural development. Domestically, economic development has entered a new normal, showing three characteristics: speed change, structural optimization and power conversion, which requires the simultaneous development of new industrialization, informationization, urbanization and agricultural modernization. In the simultaneous development of the four modernizations, agriculture is still a short board, and it is urgent to speed up the transformation of agricultural development mode and the adjustment of agricultural structure. From an international perspective, developed countries and regions are paying more and more attention to improving agricultural competitiveness, gradually eliminating direct subsidies to agriculture by adjusting laws and policies, and instead increasing support for agricultural business entities in the market field, so as to improve their competitiveness and promote the process of agricultural marketization. Facing the changes in the development environment at home and abroad, and implementing the spirit of the Fifth Plenary Session of the 18th CPC Central Committee, we should fill in the shortcomings of agriculture as soon as possible and strive to improve the agricultural competitiveness of China’s big countries.

Change the concept of agricultural development and pay more attention to the transformation of mode and structure.

The "Proposal" pointed out that to achieve the development goals during the "Thirteenth Five-Year Plan" period, solve development problems and cultivate development advantages, we must firmly establish the development concept of innovation, coordination, green, openness and sharing. The concept of development is the forerunner of development action. To develop modern agriculture and improve agricultural competitiveness under the new economic normal, we must firmly establish and implement the new development concept, and pay more attention to changing modes and adjusting structure.

The reason why we should pay more attention to changing the mode and adjusting the structure is because although agriculture is a traditional industry, its versatility is becoming increasingly obvious with the development of agriculture and economy and society. Modern agriculture should not only give play to traditional production functions and ensure food supply, but also give play to ecological and environmental protection, sightseeing and leisure, cultural inheritance and other functions to promote sustainable development. Only by establishing a new development concept and paying more attention to changing the mode and adjusting the structure can we accelerate the formation of a modern agricultural industrial chain pattern from field to table, form a modern agricultural industrial system with the integration of primary, secondary and tertiary industries, better lead the transformation of agricultural development mode and promote the improvement of agricultural development quality and efficiency. Therefore, we should speed up the transformation of extensive management methods that rely on resource consumption, strengthen the drive of agricultural scientific and technological innovation, and take the road of agricultural modernization with high output efficiency, product safety, resource conservation and environmental friendliness. On the basis of stabilizing grain production, we should scientifically determine the self-sufficiency level of major agricultural products, rationally arrange the development priorities of agricultural industries, give full play to the comparative advantages of various regions, industries and business models, promote the integration and interaction of primary, secondary and tertiary industries, and realize the transformation of agricultural production from production-oriented to consumption-oriented

Improve the innovation and extension system of modern agricultural science and technology and vigorously apply advanced science and technology.

The "Proposal" proposes to improve the modern agricultural science and technology innovation promotion system. At present, advanced science and technology plays an increasingly important supporting role in improving the comprehensive agricultural production capacity and overall competitiveness. In 2014, the contribution rate of agricultural science and technology progress in China has reached 56%. In the past, we put more emphasis on agricultural science and technology, such as improved varieties and good methods. Today, we propose to improve the innovation and extension system of modern agricultural science and technology and vigorously apply advanced technology, and its breadth and depth far exceed the cognitive scope of the past.

As far as biotechnology is concerned, it includes not only the traditional optimization of agricultural and livestock varieties, but also the modern biotechnology represented by transgenic technology. We should intensify technological research and development and industrialization, achieve the target requirements of high yield, high quality, high efficiency, ecology and safety, and effectively guarantee national food security and food safety. As far as equipment technology is concerned, it used to be more understood as a production tool to replace labor, but today it has become the basic production factor for developing modern agriculture, and the improvement of equipment technology level can greatly improve production efficiency and output benefit. Among them, special attention should be paid to the application of modern information technology. Modern information technologies such as agricultural Internet of Things, e-commerce, big data, cloud computing and global positioning system are playing an increasingly important leading and supporting role in agricultural production, processing and circulation. Especially the booming e-commerce will have a revolutionary impact on the circulation of agricultural products. Accordingly, to improve the modern agricultural science and technology innovation extension system, we need to think and plan from the strategic height that science and technology are the primary productive forces and important production factors, accelerate the establishment of modern agricultural science and technology innovation system, scientific and technological achievements transformation system, extension and application system, and accelerate the agricultural mechanization and informatization.

Constructing modern agricultural industrial system and optimizing the combination of resource elements

The "Proposal" pointed out that efforts should be made to build a modern agricultural industrial system. The main difference between modern agricultural industrial system and traditional agricultural industrial system is that the former focuses on forming a new factor combination mode through intensive investment and in-depth development of modern production factors such as financial capital, science and technology, organization and management, and promoting the steady improvement of total factor productivity and comprehensive quality of agricultural industry.

The role of modern agricultural industrial system in promoting agricultural competitiveness is mainly manifested in four aspects: specialization, scale, intensification and integration. First of all, specialized division of labor to improve labor productivity. According to the market demand and their own endowment, agricultural business entities focus on a certain field, variety or link that they are best at and most suitable for, and carry out specialized production and business activities, which can effectively improve labor production efficiency and business benefits. Secondly, large-scale production improves the land output rate. On the one hand, the moderate scale operation of land is convenient for arranging and utilizing land in pieces and improving the scale efficiency of agricultural production. On the other hand, connecting scattered land management entities through socialized services can transcend the boundaries between plots and families, promote the centralized investment of modern production factors such as capital, science and technology, management and equipment, and greatly form the spillover effect of scale management. Third, intensive management improves the efficiency of resource combination through the scientific, accurate, reduced and efficient utilization of various resource elements. Fourth, integrated development improves agricultural total factor productivity. In the development of modern agriculture, the absence of any factor of production will form a "short board effect". Only by building a modern agricultural industrial system, vigorously optimizing the combination of various production factors, and striving to realize the integrated development of production, processing, logistics and marketing, can agricultural competitiveness be effectively improved.

Change the mode of agricultural management and cultivate new agricultural management subjects

Agricultural management mode mainly includes two aspects: agricultural production mode and service mode, which is an important symbol of agricultural competitiveness of big countries. From the perspective of agricultural production mode, many new management modes, such as farm management, cooperative management and enterprise management, which are based on household contract management, have greatly promoted the commercialization, scale, intensification, specialization and organization of agricultural production. All kinds of new business entities have different functional orientation and comparative advantages, and have broad adaptability and development space. The interests of the main members of farm management are highly consistent, and the cost of labor supervision is low, which occupies a leading position in the production of breeding industry; Cooperative business entities organize scattered farmers, improve market bargaining position, reduce production and transaction costs, and have economies of scale in the integration and development of primary, secondary and tertiary industries, which is conducive to increasing farmers’ income; Enterprise management subjects have advanced technology and equipment, strong financing and anti-risk ability, and have obvious advantages in deep processing of agricultural products, logistics and distribution, carrying out innovative agricultural production and management activities, and improving agricultural added value.

From the perspective of agricultural service mode, various public welfare and business service organizations have flourished, and the professional, serialized and multi-level service models have been continuously innovated, initially forming an agricultural socialized service system led by government public service agencies and widely participated by multiple service subjects. In particular, some business service organizations provide services for farmers in the aspects of seed and fertilizer supply, agricultural machinery operation, production management, product sales, etc. by means of full trusteeship and semi-trusteeship, which neither changes the farmers’ contract relationship, but also ensures that the land is planted with people and the land can be planted well, showing great vitality in practice. It can be said that the agricultural management mode of "diversified business entities+whole-process socialized service" is an important path choice for China’s agricultural modernization and an important institutional innovation to adapt to China’s national conditions with a large population and a small population.

Cultivate new professional farmers and improve the quality of agricultural practitioners

The "Proposal" proposes to cultivate new professional farmers. This is an urgent need and an important support to solve the practical problem of "who will plant the land" and "how to plant the land well", improve the quality of agricultural practitioners and enhance the competitiveness of agriculture. The problem of "who will plant the land" is rooted in the weak competitiveness and low comparative income of agriculture, which is not unrelated to the non-professionalism of farmers. From the current practice and development trend, traditional farmers have lived in rural areas for generations, specializing in agricultural production, and are the basic groups that produce new professional farmers; After market experience, returning migrant workers have certain capital, technology and marketing capabilities, and are the core strength of new professional farmers; Rural junior and senior high school graduates have received systematic basic education and have strong ability to absorb and apply new knowledge and technology, which is the basic reserve of new professional farmers; The new farmers who master modern agricultural technology, have the concept of ecological agriculture and Internet thinking are the emerging groups of new professional farmers. Through targeted and classified vocational education and training, they can master their professional skills and improve their professional quality, become professional rural practical talents and management talents, and become new agricultural production subjects and service subjects to meet the requirements of modern agricultural development.

Grasp the national conditions in depth and give play to the comparative advantages of agriculture.

Compared with the United States, Canada, Australia and other countries with abundant agricultural resources, China’s total agricultural resources are insufficient and per capita resources are scarce. However, from the perspective of comparative advantage, there are many types of agricultural resources in China and other relative advantages, which have the conditions to improve agricultural competitiveness by giving full play to comparative advantages.

Generally speaking, China’s agricultural comparative advantages are mainly manifested in three aspects: First, comparative resource advantages. China has a vast territory, rich landforms, diverse climate, various types of agricultural resources and obvious characteristics of species diversity. For example, China’s higher plant species account for 10% of the world’s total, and mammal species account for 13%, both of which rank among the top in the world. We should make full use of this unique advantage of agricultural comparative resources. The second is comparative industrial advantages. The variety of agricultural resources in China determines the diversity of agricultural industrial structure in various places. All localities should base themselves on comparative advantages, develop different industries selectively and emphatically, and promote the formation of a modern agricultural industrial pattern with appropriate division of labor, reasonable layout and balanced total output throughout the country. The third is comparative competitive advantage. Compared with the United States, Canada and other countries, China is relatively competitive in non-resource products such as gardening and animal husbandry. Compared with Japan and South Korea, China is absolutely competitive in grain production. Giving full play to the comparative advantage of agriculture is to transform resource advantage into industrial advantage and industrial advantage into competitive advantage as soon as possible, and strive to improve the agricultural competitiveness of China’s big countries. (Zhang Hongyu)

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Riding is becoming a new top stream.

Reporter | Chen Bing

Cyclists ride on their way to Qinghai Lake in Xihai Town, Haibei Prefecture, Qinghai Province.

  At 7: 30 on weekdays, Johnny put on his helmet, tight cycling clothes and riding gloves, and came downstairs from the fifth floor with his newly bought road bike. The "speed and passion" between him and his riders will begin to be staged again.

  Since last year’s Cityride in into the pit, he has ridden more than 5,000 kilometers, two or three times a week, with a distance ranging from 30 to 40 kilometers to 70 to 80 kilometers. Johnny felt that after living in Shanghai for half a century, he found that there were so many places suitable for cycling in Shanghai. Feel the pulse of a city by green riding.

  He is 1.8 meters tall. Before riding, like many middle-aged people, he was weak, puffy, insomnia and dreamy, and his body often hurt inexplicably. In order to ride, he began to change his schedule. In the past, he basically went to bed at one or two, but now he must go to bed at ten o’clock. Regular life, coupled with moderate cycling exercise, made him lose 20 pounds in a year, and those inexplicable pains disappeared, making him look young and full of vitality.

  Young people in the cycling group have said that this 50-year-old uncle is really amazing, and climbing is faster than young people. After all, there are many people who ride on a whim, but not many who can persevere. Mike in the cycling group said that cycling is becoming a new social way for young people. A large part of the reason why he loves cycling is that he can make like-minded friends. Johnny, the uncle, was "picked up" into the group when he was brushing circles on the road. I didn’t expect the two men who were 20 years old to become each other’s senior riding companions.

  "There are more and more people riding bicycles, the bicycles are getting more and more advanced, and the riding equipment is getting more and more cool. Many people don’t really love this sport, but just want to show off. As soon as some cycling groups enter, they have to hang up their equipment, bask in their riding distance and break the wind, and inexplicably form various chains of contempt. Our group of hundreds of people is very pure, from 15-year-old high school students to 50-year-old uncles, they don’t compete for equipment, they don’t just emphasize riding speed, but stick to cycling as a healthy lifestyle. The same three views make us healthier, happier and more durable. "

  According to the data of China Cycling Association, there are about 6 million cycling enthusiasts in China, and over 100 million people ride regularly. In 2023, the total annual cycling mileage of the country exceeded 110 billion kilometers, which is equivalent to everyone completing eight 10-kilometer rides. Cityride has surpassed citywalk and become a popular outdoor sport TOP1.

Who are riding?


  As the most familiar means of transportation in Chinese, bicycles have never been so popular as they are today. After the explosion of "Citywalk", "Cityride" took its place and became a more popular fashion movement and lifestyle leisure way.

  There are about 2.8 million+notes when you enter "cycling" in an App that emphasizes lifestyle, and the number of related entries and notes such as "cycling route", "cycling equipment", "cycling wear" and "cycling to lose weight" is also 100,000+.The high-frequency keywords associated with bicycles are "healing", "decompression", "making friends" health "and" losing weight ".

  More and more people began to give up driving in a panic, giving up the subway crowded like sardines, and returning to riding bicycles to meet their commuting needs, and then began to use cycling as a sport and a social way to meet their various needs.

  Mike, born in 1992, works in a hospital in the center of Shanghai. The traffic jam made him regard cycling as his daily commute. Every day after work, he will go home along Suzhou River by bicycle. At a distance of 10 kilometers, it takes 40 minutes to ride a bike. After 20 traffic lights, this 40 minutes is his exclusive "empty time". "It was really not easy at first. I have to overcome my inner burnout and say’ Don’t give up’ to myself every day." With the adaptation of road conditions and physical fitness, he began to gradually enjoy the state of being empty when riding a bike. "During this time, I didn’t think about anything and focused on riding a bike, and those negative energies were’ kicked off’ bit by bit with the mechanized trampling action."

  Until one day, a cyclist on a road bike whizzed past him, and the feeling of being "exploded" aroused Mike’s desire to win or lose. He went to Decathlon and bought the first road bike in his life. Since then, riding Mike is full of expectations for getting off work. He unlocks the new route to go home and enjoys riding with friends after work and at night. "I can experience different scenery on the way from home and the company. The key is that cycling really makes me thin into a flash of lightning. "

  Echo is a white cyclist. As a journalist, she has the opportunity to travel to different corners of the city every day. Recently, she began to ride a second-hand Trek Mountain bike through every interview site that can be reached by bike. In her view, cycling is a sport suitable for both social cattle and social fear. "First of all, the participation threshold for cycling is very low. Most sports need someone to cooperate with you. There are more than 20 people in a football match, and at least 6 people are needed for half-time basketball. Even table tennis requires 2 people to play. The profession of journalists is used to fighting alone. It seems that nature and riding are perfectly matched, and one person and one car can ride freely. "

  Of course, on weekends, friends go together, ride beautiful bicycles, punch cards and take photos in online celebrity stores, not only can you enjoy the pleasure of riding, but you can also meet with your riders for afternoon tea or supper after riding. Even people who didn’t know each other before may become close friends because of a ride. Ike said that in this scene, cycling is a social way. Whether you are a social cow or a social fear, you can find pleasure in this sport.

  Johnny thinks cycling is for exercise. "I ride three or four days a week, a total of two or three hundred kilometers." He feels that cycling is a short-term and efficient exercise. "Riding for an hour is about 30 kilometers, which can consume more than 1,000 calories. If you are running or in the gym, you may consume half the calories." After riding for more than a year, he obviously felt that his leg strength and cardiopulmonary function were slowly improving. "Cycling will not cause sports injuries to the knee and ankle joints. If I usually play basketball or walk a long way every day, it will make my knees uncomfortable, but I ride a bicycle for dozens of kilometers and my knees are completely uncomfortable. " What makes him even more addicted is that when riding for a long distance, "riding can enter a state of meditation, relaxed, free and carefree."

  Johnny said that one day in September last year, he had a sudden impulse to go to his son’s school by bike. This flat road bike was originally prepared for my son to go to high school. As a result, my son was admitted to a boarding high school, and he usually had no chance to ride a bike. "This bicycle is specially customized by the owner of a cycling club according to his son’s height of 1.88 meters. It has a light weight and a 10-speed transmission, so it is very easy to ride. This bike ride to my son’s school is the first time I’ve ridden it for a long trip. From home to my son’s middle school, there will be several high bridges in the middle, and the road is not smooth. I push and push hard, feeling the same speed as flying. In this way, I completed the 16.8 km cycling, which took 1 hour. This speed is already very fast for me. When I came back, I slowed down, not because I didn’t want to ride at high speed, but because I couldn’t. My legs were too sour. But it was this experience that made me like cycling. Of course, at first, it was all leisure riding, but this year it began to break through itself slowly, riding more and more kilometers and getting faster and faster. The feeling of sweating is very cool, which makes people feel that the wind is full of freedom. "

On the open Riverside Greenway in Pudong, a bicycle lane with a length of nearly 24 kilometers is surrounded by green trees, and Jiang Jingyi has become a "riding holy land" for cyclists.

The road to upgrading


  When Johnny and Mike met, Mike had just bought a Xidesheng A350 from the idle fish, and they would go out for a ride two or three times a week. At the beginning, leisure riding was the main thing, and what really changed them was an experience during Labor Day this May.

  On May 2nd this year, Johnny and Mike decided to take a long-distance ride, and the destination was Dianshan Lake in Qingpu. On the way back. They rode slowly along the Huqingping Highway. After crossing Zhujiajiao on Huqingping Highway, a female rider quickly passed by them. The female rider, almost prone on the bike, pedaled her thick thighs quickly with high frequency.

  Johnny and Mike’s winning and losing hearts were activated at that moment, and they were determined to chase the female rider. Although they had ridden sixty or seventy kilometers at that time, their legs were not as light as when they came, but when they talked about chasing beautiful women, they immediately felt that their legs were full of strength. The two began to catch up with each other at an accelerated speed. The female rider in front might know that someone was chasing after her, and her legs swung faster, showing no sign of slowing down at all.

  Several times, they were left behind by female riders, and they couldn’t see her back at all. When they arrived at the next traffic light, they found that "the man was still in the dim light." Just when they thought they could catch up with her, the green light came on and she rode away quickly.

  In this way, they chased Bailian Outlets from Zhujiajiao until they could never find her back. "According to the watch on our bicycle, our average speed reached 25 kilometers per hour when chasing, so the speed of this female rider must have exceeded 25, maybe 28. In the process of catching up with this female rider, we are already studying how to ride faster. "

  After improving their riding posture and pedaling rate, they began to pursue the advanced road of speed. Of course, the first step on the road to advancement is to change to a more advanced car. Johnny bought a new car worth 8,000 yuan, while Mike upgraded directly to a carbon fiber bicycle worth tens of thousands of yuan. Before, Mike rode casually, until he bought a professional cycling suit, only to find that the wind resistance was really reduced a lot.

  However, both of them have repeatedly stressed that "everyone wants to buy a good bicycle, which is the same as buying a car. Chery QQ can drive, Tesla can drive, and Ferrari can drive. Although any car can be ridden, it is definitely a point price. The more expensive the bicycle, the better its performance and the stronger its psychological satisfaction. " For young Mike, a good car is a kind of "social currency" on some occasions, which can reflect his own strength.

  In fact, any sport may burn money in the end. In-depth professional cycling requires not only buying cycling equipment such as bicycles and meters, but also wearing products such as shoes, clothing, socks and helmets. With a little matching, it will cost thousands or even hundreds of thousands of yuan.

  Wang Laoqi runs a cycling club in Chongming, which not only assembles and refits all kinds of bicycles, but also holds various cycling activities regularly. In his view, it is true that some riders’ fun comes from upgrading and transforming vehicles. "From the perspective of the overall domestic bicycle market, the price range of high, medium and low-end cycling equipment is relatively large. The price of a bicycle can range from 500-800 yuan in the middle and low end to more than 100,000 yuan in the high end. Cyclists and riders can choose cycling equipment according to their own economic situation and consume rationally."

  “高端装备主要是为竞技目的打造的,未必适合每一个骑行爱好者。在车辆选择方面,初学者和骑行经验较少的参与者前期可以选择共享单车,或者购买初级款山地自行车、小轮车、城市综合自行车;已经充分掌握骑行技巧后,再选择专业公路自行车或专业山地自行车。”王老骑建议,骑行装备量力而行即可,骑什么车其实并没有那么重要,人们更应该关注骑行本身带来的快乐,而不应掉进不断提升装备的“陷阱”之中。“我的俱乐部中也有很多骑普通自行车的中老年成员,他们同样可以挑战长距离的公路骑行。”

“Cityride”热潮持续



北京天安门附近路口四面八方涌来的骑行者。


  实际上,骑行热正在席卷大江南北。“夜骑长安街”从去年“爆火”到现在,这股骑行风尚的热潮仍未褪去。骑行,这一曾被视为寻常通勤方式或悠闲周末消遣的活动,正以势不可挡之势晋升为2024年户外运动的顶流。

  According to the latest data of China Cycling Association, the cycling population in China has increased by nearly 30% compared with the same period of last year, and the total cycling mileage has doubled. With the continuous improvement of urban infrastructure and the continuous improvement of air quality, a large number of bike-sharing have provided convenience for cycling, making cycling the first choice for more outdoor sports enthusiasts.

  Not only are there more and more people riding at night, but the number of cycling enthusiasts in the morning is also surging, and a variety of "Cityride" routes are frequently marked. Relevant data show that cycling has become the top three popular sports in the network exposure index, and cycling clubs and online cycling communities have sprung up. In a year, there are more than 5,000 bicycle races at all levels-30 km circle race, 100 km ring race, 300 km endurance race, as well as 1,200 km devil riding and triathlon. There is always one for you.

  After upgrading their equipment, Mike and Johnny quickly attended the bicycle riding conference held in Chongming Island in May this year. The cycling team is divided into two lines: 200 km and 120 km and a half, passing through forests, villages, wetlands, lakes and other different landforms, which makes people fully feel comfortable and carefree riding on a world-class ecological island. Every weekend after that, they will participate in almost all kinds of cycling activities.

  Mike admits that he is very keen to participate in cycling activities organized by various cycling clubs. He said that he likes to be lively. It is easy to release pressure by sharing bicycle modification skills, "breaking the wind" and sharing the beautiful food along the way with his riders during riding. "However, urban roads are not particularly suitable for cycling, and they will go to the suburbs or other places to ride. Generally, cars or buses take everyone and bicycles to the suburbs of Shanghai or relatively empty areas such as Jiangsu and Zhejiang, such as Qingpu District and Chongming District. There are cycling lanes and green roads specially guided by the local government. 200 kilometers, it can be ridden in almost 6 hours. " From Decathlon RC100 to carbon fiber bicycles worth tens of thousands of yuan, Mike completed the upgrading of riding equipment. Because of a collision with a battery car, he turned outdoor riding at night into riding platform practice. "Although the car didn’t suffer too much loss, I don’t think road riding can improve my level. The practice of riding platform is more professional and improves the level faster. I often connect with my friends to ride races now, refreshing my distance and speed again and again, and I don’t rule out participating in more races next. "

  Mike’s transformation actually reflects a series of challenges behind the cycling craze to some extent. How should cities increase infrastructure construction and optimize the riding environment? How to improve riding safety, improve relevant laws and regulations, and protect the rights and interests of cyclists and other people on the road (pedestrians and runners)? How can enterprises and clubs use the power of science and technology to innovate riding products and services and enhance the riding experience? How can society guide more people to participate in cycling and promote the development of cities in a more humane and sustainable direction?

  There is no doubt that cycling has not only changed our way of life, shaped a new urban landscape, but also outlined a beautiful picture of our future life with its green, healthy and social characteristics. Only by solving the above problems can the cycling craze lead us to a healthier, more environmentally friendly and more harmonious future. Reporter | Chen Bing

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Pentium pony strives to create a new life with smart driving, which one is more cost-effective?

Although cars can improve the convenience of people’s travel, safety is still an unavoidable topic. Therefore, many car companies have begun to upgrade the safety of their models. Of course, for consumers, a car with complete active and passive safety configurations will be more popular. The richness of a car configuration is related to the user’s car experience, so many people are concerned about its configuration today. Let’s take a look at it next.

First of all, from the appearance, the design style of Pentium pony head has taken a steady route, which is very sporty. Headlights are simple and fashionable, and the design is more fashionable and dynamic. The car is equipped with etc. Coming to the side of the car body, the size of the car body is 3000MM*1510MM*1630MM, and the car adopts simple lines, which gives people a very streamlined feeling. With large-sized thick-walled tires, the shape is eye-catching. In the design of the rear end, the overall shape of the rear end of the Pentium pony echoes the front face, and the taillights look very comfortable and have a rounded shape.

When I came to the Pentium pony car, the interior shape looked very simple and the overall shape was remarkable. The car looks very good outside the steering wheel, made of plastic, showing a sense of atmosphere. Take a look at the central control. The design of the center console is reasonable, which makes the interior style impressive and has a certain sense of science and technology. The dashboard and seats are equally eye-catching. The dashboard of the car presents a simple design style, highlighting the trendy temperament. The car uses fabric seats, which are wrapped in place and are basically enough for daily use.

Pentium pony matching gearbox, 30KW, 90N.m, good power performance.

The car is equipped with Bluetooth /WIFI connection, sunshade mirror, USB interface, uphill assist, rear reversing radar and other configurations, and the configuration performance is passable and basically satisfactory.

After reading the above introduction, let’s make a summary. Such a car with the right price is enough to meet the daily practical needs, and it doesn’t take much thought to maintain it at ordinary times, and the cost performance is good.

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Nakamura Shido dumped Meisa Kuroki and cohabited with a handsome white-collar woman.


Nakamura

    Nakamura Shido, a Japanese kabuki actor who has appeared in films such as Red Cliff one after another and is well known to China audiences, has recently been found to be madly in love with a female white-collar worker who graduated from Waseda University, even to the point of talking about marriage. According to FRIDAY, a photo magazine published on January 14th, 38-year-old Nakamura Shido was photographed buying a wedding ring with a 27-year-old female white-collar worker, thus speculating that Nakamura is about to enter the marriage hall for the second time.

    Nakamura Shido, who divorced actress YUUKO TAKEUCHI in 2008, has a son with his ex-wife, Takeuchi, who is now 5 years old. After the divorce, Nakamura was once rumored to be in love with 22-year-old Meisa Kuroki, but both denied it.

    According to the new issue of FRIDAY, the rumored girlfriend who is in contact with Nakamura has a short hair style, and the whole person looks particularly handsome. After graduating from Waseda University, she worked as a magazine graphic model during her school days, and became a white-collar worker of a silver jewelry brand company after graduation. On January 3, the magazine photographed Nakamura and the woman going to a jewelry store in Tokyo, and Nakamura chose a wedding ring for them. From their sweet smiles, it can be seen that they are by no means ordinary men and women. The magazine also revealed that Nakamura had started living together with this woman.

    According to relevant sources, Nakamura and this woman met through a friend’s introduction at an endorsement event in the summer of 2010, but the marriage was denied by this insider. "I don’t think it will be so soon … …” . After the divorce, Nakamura always avoided talking about emotional topics, but in recent interviews, Nakamura changed his previous avoidance attitude. When asked if he would get married within the year, Nakamura once said with a smile: "I will work hard!" The words reveal the expectation of remarriage.

[Movie Network]www.1905.com Exclusive manuscript, please indicate the source.

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Late-night construction also brings dust rolling? These problems that plague people’s lives have been …

Original title of this article: "Does the construction in the middle of the night bring dust rolling? These problems that plague citizens’ lives have been dealt with! 》

Dear friends,

The weekly [Echo] is coming again!

The mixer truck raises dust and the construction noise at night is loud?

Lack of road control, there are great security risks?

The school gate will be flooded whenever it rains, making it difficult to pass?

……

This week’s [Echo]

Continue to solve your problems!

reply

(No.39, 2018)

???

01

User message content

Longxi Mountain, Gaoyao Country Garden, rushed to work day and night, and 2 tons of cars were forbidden to pass through this section. The mixer still shuttled through Cologne Street at 2 or 3 in the morning, raising a lot of dust, and did not sprinkle water on the road to reduce dust, which had a great impact on the life and travel of nearby residents. The dust was rolling during the day and the noise was constant at night. I hope the relevant departments would pay attention to it.

Gaoyao district Committee office

answer

After verification, netizens reported that the situation was true. The construction unit has implemented water spraying and dust removal, but the frequency is not enough, and the dust removal effect is not ideal.

On October 26th, a joint working group was formed by the departments of housing, construction, environmental protection, transportation and traffic police in our district. The person in charge of the Longxi Mountain construction project in Country Garden and the person in charge of the construction unit were interviewed, and the situation reflected by the netizens’ messages was reported to the person in charge. The project construction party was required to strictly abide by various rules and regulations to carry out construction and production according to law, reasonably arrange the construction time, and limit the impact of environmental pollution problems such as dust and noise on the surrounding residents to the greatest extent. It is strictly forbidden to overload and carry vehicles. That night, traffic, traffic police and other departments set up cards around "Country Garden Longxi Mountain" to enforce the law, and rectified the traffic violations of dump trucks, and the rectification action received certain results.

On October 27th, the working group formed a rectification plan on relevant issues as follows:

First, it is forbidden for the construction unit to carry out construction at night (from 22:00 pm to 6:00 am the next day), and the District Housing and Construction Bureau is responsible for supervision. If the construction at night is found, it will be ordered to stop work immediately for rectification.

Second, because the traffic of trucks over 2 tons is restricted in Cologne Street, construction vehicles must bypass the construction site through other roads to avoid dust and noise disturbing people, and the traffic police and transportation departments are responsible for supervision; The District Traffic Police Brigade carries out technical maintenance and upgrade of monitoring equipment in Cologne Street, and the District Transportation Bureau urges the owner to install weighing equipment at the cargo loading site and assign special personnel to manage it.

Third, the construction unit is required to increase the frequency of sprinkling water to reduce the dust on the road section, and the district environmental protection bureau is responsible for supervision.

In the next step, housing, construction, environmental protection, transportation and other departments will establish a linkage mechanism, strengthen joint law enforcement, conduct night inspections, and severely punish violations found. The traffic police department will implement the service system and increase the patrol monitoring of this section by setting up cards and taking irregular measures.

02

User message content

1. On the Hengda Haoting section of Dinghu 321 National Road, even if you can enter the auxiliary road after turning around from west to east, there is no municipal road that can turn into Hengda Haoting. Every day, many people from Duanzhou to Dinghu turn around here and then take the path next to the gas station to enter Hengda Haoting Road. Because it is not a municipal road, the road surface is not maintained and there is no safety control, which has great security risks. It is recommended to improve it!

2. Since the construction of National Highway 321, Xinyuan No.1 Street in Dinghu District has been flooded in every heavy rain, especially when typhoons such as Tiange and Mangosteen arrive, and even the flooding depth is more than 1 meter. The surrounding residents have repeatedly reported their problems to the petition offices and sub-district offices, but they have not received any reply or rectification.

Dinghu district Committee office

answer

(I) About the problem of netizens reflecting the section of Evergrande Haoting.

It is understood that the path that enters Taihe gas station after the U-turn of Hengda Haoting section of National Highway 321 is not a municipal road, but is owned by the gas station. The person in charge of the commercial gas station has no intention to maintain the path at present. Next, our district will strengthen the safety supervision around this section in conjunction with the traffic police department to ensure the travel safety of surrounding residents.

(2) About netizens reflecting the flooding problem in Xinyuan Street.

It is understood that due to the influence of Typhoon Mangosteen No.22 this year, from September 16 to 18, heavy rain continued to fall in our area, with local heavy rain, and the maximum rainfall recorded at Kengkou was 269 mm. Xinyuan First Street was one of the areas where flooding occurred.

During Typhoon Mangosteen, the rainfall lasted for a long time and was heavy, which greatly exceeded the design capacity of urban sewers and drainage standards, making it difficult to drain the rainwater on the pavement in a short time, and flooding occurred in many places in the area to varying degrees. Xinyuan 1st Street mentioned in the letter must be flooded in heavy rain after the construction of National Highway 321. The reason is that the elevation of the road surface has been improved after the urbanization of National Highway 321, which makes Xinyuan 1st Street relatively low-lying and prone to flooding.

In view of this situation, our district will speed up the construction progress of Xinshengtian Canal, complete the project construction as soon as possible under the premise of ensuring the quality, and strive to put it into use as soon as possible, so as to reduce the drainage pressure of urban sewers and reduce the flooding problem during the torrential rain in the district. In addition, the water department of our district has organized the construction team to comprehensively clear the municipal sewers of Xinyuan First Street and surrounding roads to ensure the smooth drainage of sewers in this area. In the next step, our district will refer to the vertical of surrounding roads and other factors, and appropriately adjust the ground elevation of Xinyuan Street to minimize the problem of road surface water accumulation.

03

User message content

1. The road at the gate of xinhua primary school will be flooded whenever it rains, and the water depth is more than 20 centimeters. Primary school students cannot pass after school, so parents need to carry it. I hope the relevant departments will go to the field to investigate and study solutions.

2. Two fans on the Blue Sky Water Gathering Building of Duanzhou Shanghai City Phase II roared for 24 hours. Standing on the balcony, I felt my ears tingle. I didn’t even dare to open the doors and windows at home. I couldn’t sleep when I opened the windows. I have reported to various departments that no one has handled them many times. Blue Sky Shuihui is a clubhouse, which is opened so close to the community. It is not legal at all. A few days ago, I heard the voice of singing K in the middle of the night.

Duanzhou district government office

answer

(1) About the problem that netizens report that the road at the entrance of xinhua primary school will be flooded when it rains.

According to the field investigation, xinhua primary school is located on the land on the east side of Xinghu Avenue and the north side of Donghu Road, which is lower than the municipal roads. The road at the entrance of xinhua primary school belongs to the village road, and drainage pipes and wells have not been built around it. The urban drainage network management center regularly cleans and maintains the municipal drainage pipelines of Xinghu Avenue and Donghu Road to keep the pipelines unblocked. However, due to the lack of supporting drainage facilities and municipal drainage pipelines around xinhua primary school, and the fact that it is located in a low-lying area, rainwater cannot be drained when it rains, so it is easy to form flooding in rainy days. Our district has urged Huanggang Sub-district Office to organize Fenggang West Village to do its best to do the pumping and drainage work of this section in rainy days, and dredge the drainage channels to reduce the impact of stagnant water.

As the north side of xinhua primary school is reserved land for the expansion of Honghu Lake, it will be built by the Municipal Construction Bureau. The next step in this area will be drainage planning and construction together with Honghu Lake, which is transferred to the east. After the drainage network in this area is improved, the flooding problem of the road at the entrance of xinhua primary school can be completely solved.

(B) About the problem that netizens reported that the noise of Shanghai Blue Sky Water Club Phase II disturbed people.

Upon investigation, the name of the place mentioned in the complaint is Duanzhou Blue Sky Holiday Leisure Center (hereinafter referred to as "Blue Sky Shuihui Club") registered in the administrative department for industry and commerce. Duanzhou Sub-bureau of City Comprehensive Law Enforcement Bureau received a report on the disturbance caused by the fan noise of Blue Sky Shuihui Club in early June. After repeated urging by law enforcement officers on June 8, July 11, July 17 and August 6, the club moved two fans on the roof that were originally close to residential buildings to the direction of the road, and connected the extended air ducts of the fans to the sound isolation box, which significantly reduced the noise.

According to the situation reflected by netizens, Duanzhou Branch of the Municipal Comprehensive Law Enforcement Bureau and the District Cultural and Sports Bureau sent law enforcement officers to the scene for mediation. On-site inspection found that in order to reduce noise and avoid noise spread, the club also closed the kitchen window. On the morning of October 10th, law enforcement officers contacted the relevant complainants by telephone to inform them of the handling situation and will monitor the noise of Blue Sky Holiday Leisure Center together with the municipal environmental monitoring station. The complainant expressed satisfaction and understanding of our work.

In the next step, our district will urge Duanzhou Branch of the Municipal Comprehensive Law Enforcement Bureau and the Municipal Environmental Monitoring Station to monitor the noise of the clubhouse as soon as possible, and follow up according to the monitoring report.

04

User message content

The industrial zone on the west side of Xiangang Toll Station often uses night time to secretly discharge harmful waste gas and smoke, which causes people living nearby to have difficulty breathing and seriously affects their health! We have repeatedly complained ineffectively, and now we question whether there is a problem with the efforts of the functional departments to implement the national environmental protection policy.

Gaoyao district government

answer

Recently, the environmental protection bureau of our district has received two complaints about the waste gas pollution in the industrial zone on the west side of the Xian Gang toll station, which the district environmental protection bureau attaches great importance to. Since the beginning of this year, in response to the problem of waste gas pollution in Xiangang Industrial Zone, the District Environmental Protection Bureau has repeatedly conducted surprise inspections with the People’s Government of Xiangang Town on enterprises in the industrial zone, and filed investigations on 14 enterprises with environmental violations, which severely cracked down on environmental violations of enterprises in the region. At the same time, since the creation of our district, the government of Xiangang Town has established a grid system, strengthened supervision and inspection of enterprises in the industrial zone, and required relevant enterprises to implement the environmental management system.

After receiving complaints from the masses, on the evening of October 10, 2018, the law enforcement officers of the District Environmental Protection Bureau, together with the staff of Gaoyao District Environmental Protection Monitoring Station and third-party testing institutions, went to the complaint area to conduct supervision and inspection, and sampled and monitored the ambient air at the northeast side (near the exit of the toll station), south side (in the junior middle school) and west side of the complaint area, and will focus on tracking and inspecting the enterprises near the relevant area according to the results of the ambient air monitoring report.

At the same time, the enterprises involved in waste gas emission and producing at night (Zhaoqing Gaoyao Hongzhan Hardware Plastic Co., Ltd., Chongqing Gaoyao Jinyi Aluminum Co., Ltd., Zhaoqing Gaoyao Zhaoxing Industry and Trade Co., Ltd., etc.) were monitored for waste gas. During the inspection, law enforcement officers found that the exhaust gas collection in the drawing and granulating workshop of Hongzhan Hardware & Plastic Co., Ltd. in Gaoyao District of Zhaoqing City was not perfect and the workshop was irritating, so they immediately asked the company to stop production and rectify. The next day, the district environmental protection bureau issued a notice to the company to stop production and rectify, requiring the company to resume production after the rectification is completed and reported to the bureau for inspection.

In the next step, the District Environmental Protection Bureau will continue to strengthen the supervision and inspection of gas-related enterprises in the industrial zone on the west side of the Xiaogang toll station, and intensify inspections. Once suspected environmental violations are found, they will be seriously investigated and dealt with according to law. At the same time, the district environmental protection monitoring station and third-party testing institutions are required to increase the frequency of spot checks and monitoring of gas-related enterprises near the complaint area, and investigate the enterprises suspected of exceeding the standard discharge according to law.

That’s all for this issue.

If the neighbors have problems to reflect

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Is cell therapy reliable in treating cancer? CAR-T leads the world, and 10 popular and emerging cellular immunotherapy show their magical powers!

The incidence of malignant tumor is increasing year by year, which has become a common problem faced by human beings. Traditional treatment methods such as surgery, traditional chemotherapy and radiotherapy have always played a leading role in cancer treatment, but the effects of these treatments are limited. In particular, it is difficult for advanced patients to benefit from these treatments for a long time, nor can they fundamentally solve or change their quality of life. Therefore, researchers are increasingly focusing on the field of immunotherapy. Immunotherapy has brought new opportunities and hopes for the treatment of tumors, among which Immunocheckpoint inhibitors, therapeutic antibodies, tumor vaccines, immunomodulators, adoptive cell therapy, etc. Significantly improved the prognosis of cancer patients, and some patients with advanced cancer obtained long-term survival. In the past two years, many cellular immunotherapy have emerged and developed rapidly, which undoubtedly set off a wave of cancer treatment. So, is cell therapy reliable in treating cancer? In fact, immunotherapy has a history of more than 100 years, and it has only gradually entered the public’s field of vision in the last two years, and it has been absolutely recognized by the world oncology community.   

20731650935352411   

A milestone in the history of cancer immunotherapy In 2013, Science magazine ranked the top ten scientific breakthroughs of the year, and immunotherapy topped the list. In recent years, immunotherapy is one of the hot spots in the research field of tumor treatment at home and abroad, and a large number of clinical studies have shown exciting results. Among them, Cellular immunotherapy uses the self-protection and killing ability of human immune system to achieve anti-tumor effect. Cells with immune function in patients are cultured and proliferated in vitro, and they are given the ability to attack tumor cells by technical means, and then they are imported into patients to realize their own anti-cancer. This therapyAgainst immune cells, not cancer cells.It is not as harmful to the patient’s health as surgery, radiotherapy and chemotherapy. Patients with early cancer can be treated directly, especially with the attack on residual cancer cells after surgery. Judging from the rapid development in scientific research and clinic in recent years, cellular immunotherapy is expected to become the fourth pillar of anticancer therapy in terms of accuracy, effectiveness and safety. Next, the small series of Cancer-free Home gives a general introduction and inventory of a variety of popular and emerging cellular immunotherapy in the biomedical industry, hoping to give cancer friends a general understanding of the general development process of this cancer treatment field. 

0one  CAR-T cell therapy

CAR-T therapy is chimeric antigen receptor T cell immunotherapy, which is a new precise targeted therapy for treating tumors. T cells are activated by genetic engineering technology, and the positioning navigation device CAR (tumor chimeric antigen receptor) is installed to transform the ordinary "warrior" of T cells into "super warrior" CAR-T cells, Specially identify tumor cells in vivo and kill tumor cells efficiently. So as to achieve the purpose of treating malignant tumors. At present, with 2021, Aquilencel injection, Regioscel injection. It was approved for listing in China, in 2022.Cedarchiorense was approved for listing by FDA.CAR-T therapy is expected to enter the blowout period. Indeed, CAR-T technology has shown good curative effect in many hematological tumors, such as leukemia, lymphoma and multiple myeloma, and more than half of hematologic cancer patients who are on the verge of despair and have no cure have achieved good curative effect.  

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CAR-T cell therapy has been listed at home and abroad at present.

Although the clinical effect of CAR-T therapy on solid tumors is not satisfactory, and it has even been sung down by some people, in recent years, CAR-T therapy has made outstanding progress in the fields of gastric cancer, liver cancer and pancreatic cancer. Scholars at home and abroad have made various modifications to CAR-T, and constantly found new targets for the treatment of various solid tumors.    

Clinical study on CAR-T therapy is out of the loop.

0one Gastric cancer and pancreatic cancer As the first CAR-T cell targeting Claudin18.2 in the world, CT041 emerged as early as the ASCO annual meeting in 2019. At that time, the total objective remission rate was 33.3%, which already surprised the world. Now the more remarkable curative effect is undoubtedly the icing on the cake! This clinical data shows a good treatment prospect for digestive system tumors!

Domestic CAR-T therapy CT041 first appeared in ESMO

Developed by Keji Pharmaceutical at the annual meeting of the European Society of Oncology (ESMO) in 2021.Targeting Claudin18.2(CLDN18.2)Autologous CAR-T candidate productsCT041Showing its presenceDigestive system tumorThe outstanding curative effect can be described as brilliant!

The research data is particularly eye-catching!

1. All patients’The objective remission rate was 48.6%, and the disease control rate was 73%.All patients with gastric cancerThe total objective remission rate was 57.1%.

2. Patients with gastric cancer who failed to receive at least 2 lines of treatment in the past:The objective remission rate was 61.1%, and the disease control rate was 83.3%.

3. And the overall tolerance is good!

As of March 3, 2022,CT041 became the first and only CAR-T cell candidate product in the world for the treatment of solid tumors, which entered the confirmatory phase II clinical trial.This is a milestone for CAR-T to conquer the solid tumor field. Congratulations!

In addition, there are many CAR-T cell therapies targeting CLDN18.2.0 2 liver cancer At present, the clinical trial targets of CAR-T in the treatment of liver cancer are mainlyGPC3 (phosphatidylinositol proteoglycan 3). The breakthrough research results completed by Professor Zhai Bo, director of the Department of Tumor Interventions, Renji Hospital affiliated to Shanghai Jiaotong University School of Medicine, were published in the international authoritative journal Clinical Cancer Research on May 5, 2020. By July 24th, 2019, 13 patients had received CAR-GPC3 T cells with a median value of 19.9×108. All the patients are GPC3 positive, and they have received surgical treatment, local treatment or systemic treatment, and they all carry hepatitis B virus (HBV). Two patients achieved partial remission (PR). The 6-month, 1-year and 3-year survival rates of all patients were 50.3%, 42.0% and 10.5% respectively, and the median survival time (OS) was 278 days (39.7 weeks). At the ASCO annual meeting in 2021, Chinese medical researchers published the latest clinical research data of CAR-T drug targeting GPC3 (Ori-CAR-001) in the treatment of recurrent/refractory hepatocellular carcinoma for the first time. As of March 10, 2021, a total of 11 recurrent subjects who received cell infusion were included.All the subjects had advanced hepatocellular carcinoma, and none of them were effective after chemotherapy, TACE (transcatheter arterial chemoembolization) and targeted therapy.Of the 9 evaluable subjects,4 cases achieved partial remission (PR), 3 cases achieved disease stability (SD) and 2 cases developed disease progression (PD).The objective remission rate was 44%, and the disease control rate reached 78%.. 

02  Treatment of tumor infiltrating lymphocytes (TIL)

TILs therapy, simply speaking, is to separate and purify the lymphocytes in the tumor tissue after surgery, select the lymphocytes that can specifically resist cancer, and then amplify and activate them and reinfusion them. This kind of therapy has a history of more than 30 years, and it was first used for malignant melanoma. In recent years, it has given good data in many solid tumors such as cervical cancer and lung cancer.

This therapy is equivalent to pulling back veterans with combat experience directly from the battlefield. After a round of "political review" and "big competition" in professional ability, the spies and traitors are eliminated as far as possible, leaving the ones with the strongest fighting capacity, providing supplies, and then sending them back to the battlefield to continue fighting. Looking at the whole industry, the voice of "innovative therapy based on Tiles cells LN-144 (Lifelecel) is expected to be approved in 2022" is particularly loud. Tiles therapy, as an "ancient" cell therapy, is expected to usher in the first approved product this year, and its great potential in treating solid tumors can not be underestimated, with strong strength and relatively "out of the circle". TILs domain key node event     In 1982  

Steven A.Rosenberg and others discovered for the first time that TILs can inhibit the metastasis of melanoma cells in patients.

  1988  

The earliest attempt of TILs in clinical treatment: TILs therapy for metastatic melanoma achieved an objective remission rate of 60%.

  In 2011  

Steven A.Rosenberg and others published a phase II clinical research data in Clinical Cancer Research: the objective remission rate (ORR) and complete remission rate (CR) of patients with melanoma treated by TILs were 56% and 24% respectively.

  In 2012  

Melinda Bachini, a patient with advanced intrahepatic cholangiocarcinoma, is called the first patient to achieve complete remission (CR) after TILs therapy.

  2019  

At the ASCO meeting, the clinical results of innovative therapies LN-145 and LN-144(Lifileucel) based on TILS cells in the treatment of cervical cancer and melanoma have attracted wide attention in the medical field.FDA awarded LN-145 breakthrough therapy recognition.

  In 2021  

Phase I clinical results of TILs cell therapy at AACR meeting: among 12 evaluable patients.Non-small cell lung cancer patientsMedium,TIL therapy can achieve a total remission rate of 25%, among whichTwo patients achieved lasting complete remission.

  In 2021  

At the annual meeting of tumor immunotherapy association (SITC), the clinical research results of LN-145 in the treatment of metastatic non-small cell lung cancer (mNSCLC) showed that in 28 cases,In patients with recurrent/refractory mNSCLC,After LN-145 monotherapy,The overall remission rate (ORR) was 21.4%(1 case of CR and 5 cases of PR, including 2 cases of PD-L1 negative tumors), 12 cases were stable, and the disease control rate (DCR) was 64.3%.

03  TCR-T therapy

CAR-T cells and TCR-T cells belong to T cells modified by genetic engineering technology.Compared with CAR-T therapy, TCR-T therapy has unique advantages in the field of solid tumor treatment. TCR-T cell therapy can identify tumor-specific antigens from cell membrane surface or intracellular sources, and has entered clinical application from the initial basic immune research, showing initial efficacy in solid tumors, and has become the most likely T cell immunotherapy to make a breakthrough in the field of solid tumors! 

1、 TCR-T cell therapy in China has been approved for clinical use and has become a potential new therapy for HBV-related hepatocellular carcinoma!

At present, in addition to the global TCR-T in full swing in the research and development and clinical verification stage, China is also constantly breaking through innovation.

On December 22nd, 2021, CDE (Drug Evaluation Center) official website was able to inquire about the clinical application of "SCG101 Autologous T Cell Injection", which is a TCR-T cell therapy for specific hepatitis B virus (HBV) epitopes and a potential new therapy for HBV-related hepatocellular carcinoma (HCC).

2881650935354255

▲ Image source: CDE official website

2、 Advanced liver cancer ushered in a new dawn! TCR-T therapy makes cancer patients completely relieved.

As early as 2020 International Hepatology Conference (ILC), ADP-A2AFP, a new TCR-T therapy for liver cancer based on T cells, caused quite a stir, and also made a new breakthrough in the new therapy for liver cancer.

Among the included patients,One patient showed a complete remission (CR) in cancer progression, and the AFP of the other participants also decreased to varying degrees.This means that the experiment has made progress, and it also shows that this therapy is effective for the treatment of advanced liver cancer.

             

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All the 9 patients involved had undergone surgery and conventional radiotherapy and chemotherapy, but failed or became intolerant. Among the 4 patients who received the highest dose of treatment,One patient achieved complete remission, and CT scan showed that all the lesions in the patient disappeared, and it has lasted for more than half a year without any recurrence!

The best response of other patients (cohort 1, cohort 2) is stable. 1 patient in queue 2After one month of treatment, the volume of the primary lesion did not decrease, but the volume of mediastinal lymph node metastasis decreased obviously!       

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Therefore, TCR-T therapy targeting AFP (alpha-fetoprotein) can kill tumor cells expressing AFP. Based on the positive results of this study, researchers are expected to expand the maximum dose to 5 billion cells, and we look forward to the publication of updated data of this study!

04  CAR-NK therapy

In recent two years, in addition to CAR-T therapy, another new cancer cell therapy- Natural killer (NK) cell therapy It has also gradually attracted attention. The researchers said, NK cell As a cell anticancer therapy, it has more potential, and it may be safer, cheaper and faster. CAR-NK is to add a chimeric antibody to NK cells by genetic engineering that can recognize tumor cells and activate NK cells to kill tumor cells at the same time. 

one   The first "spot" CAR-NK clinical trial in China was approved by the Food and Drug Administration. On November 11, 2021, National Medical Products Administration Drug Evaluation Center passed an independent research and development in China. Mesothelin (MSLN) chimeric antigen receptor NK cells (CAR-NK) injection for the treatment of advanced epithelial ovarian cancer. Application for clinical trial of CAR-NK injection. According to the cancer-free home, This product is the first "spot" CAR-NK product of foreign origin in China. This also marks a new milestone in the research of immune cell drugs in the treatment of solid tumors in China! 

2  The 1-year survival rate doubled, and the curative effect of CAR-NK therapy in solid tumor increased sharply.

Recently, the journal Clinical Oncology Research published a phase II clinical trial for lung cancer. Heat shock protein 70(Hsp70) is highly expressed in about 70% of middle and advanced lung cancer. NK cells are activated by Hsp70 in vitro, which is equivalent to making NK cells meet their future enemies in vitro, "making enemies" first, and then returning them to patients, so that NK cells can formally fight with cancer cells in vivo. This method of stimulating NK cells with antigen peptides in vitro and giving them certain specificity is a hot topic in recent years.

A total of 16 patients with stage III non-small cell lung cancer were enrolled in this clinical trial. One group received traditional chemotherapy combined with radiotherapy and chemotherapy, and the other group received chemotherapy combined with Hsp70 pre-stimulated NK cell reinfusion.

The results show that:The one-year survival rate can be doubled from 33% to 67% by Hsp70 pre-stimulated NK cell reinfusion therapy combined with traditional radiotherapy and chemotherapy, and the preliminary results are encouraging.

Next, Xiaobian shows a typical successful case in combination therapy, as shown in the figure:After 1~2 months of treatment, the lung tumor completely disappeared and the curative effect has been maintained for 18 months.

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In addition to the above-mentioned clinical studies at home and abroad, CAR-NK cells also have a good effect on glioblastoma and neuroblastoma, specifically recognizing and killing breast cancer cells with high efficiency, and have a remarkable effect on multiple myeloma.

05  Dendritic cell vaccine

Cancer vaccine is a form of immunotherapy, which can prevent cancer from developing or kill existing tumors by stimulating or restoring the human immune system. Dendritic cell (DC) vaccine is a new biological therapy for malignant tumor in recent years, which has been paid more and more attention and recognized by oncologists. As an important member of the human immune defense system, Dendritic cells have the strongest antigen presenting function and are known as "sentinels" of the immune system. It is named because its cells extend outward with many dendritic protrusions. It mainly uses modern high-tech biotechnology to collect the peripheral blood of tumor patients, induce and cultivate a large number of dendritic cells in a short time in vitro, and equip them with immune cells that patients do not have, so as to accurately "target" and kill cancer cells. Not only that, It can also induce immune memory in patients, so that patients can obtain long-term anti-cancer effect.

DCVAC/LuCa is a dendritic cell vaccine developed by the United States for patients with non-small cell lung cancer.In a study on the first-line treatment of advanced lung cancer announced at the ASCO conference in 2019, DCVAC/LuCa vaccine combined with chemotherapy groupThe objective remission rate is 45%,The median overall survival time was 15.5 months, and the median progression-free survival time was 6.74 months.Reduce the risk of death by 46%!

In the Phase II clinical study of the latest novel dendritic cell vaccine DCVAC/LuCa (lung cancer dendritic cell vaccine) combined with standard carboplatin/pemetrexed in the treatment of advanced non-squamous cell (nsq) non-small cell lung cancer in 2022,The 1-year survival rate was 72.73% and the 2-year survival rate was 52.57%.By the time the data was published, the median overall survival time had not been reached. The median progression-free survival time was 8.0 months, and the objective remission rate was 31.82%.

  Prostate cancer-Provenge vaccine  

Provenge is the first vaccine approved for treatment in the United States, which initiated a new era of cancer immunotherapy.This is an autologous cell immunotherapy, which was approved by FDA on April 29, 2010 to treat asymptomatic or mild mCRPC. This approval marks the success of 20 years of unremitting efforts.In the United States, Provenge is the only FDA-approved immunotherapy for prostate cancer made from patients’ own immune cells.

  Ovarian cancer-dcvac/ovca vaccine  

At the 50th annual meeting of the Society of Gynecological Oncology (SGO) in 2019, the final result of SOV02, a phase II clinical trial, was announced: DCVAC/OvCa, an immunotherapy based on dendritic cells, was added to standard carboplatin and gemcitabine schemes for patients with recurrent, platinum-sensitive and epithelial ovarian cancer.It can prolong the overall survival (OS) of patients with advanced recurrent ovarian cancer by more than one year.andDCVAC/OvCa reduced the death risk of second-line treatment of ovarian cancer by 62%. The overall survival (OS) increased significantly by 13.4 months. The median progression-free survival rate (mPFS) increased by 1.8 months. The global phase III study will be launched soon.

Melanoma-TLPLDC vaccine

The subgroup analysis results of the phase IIb clinical trial of TLPLDC vaccine in the treatment of melanoma were published at the ASCO-SITC Clinical Immunooncology Conference in 2020.

In that population analysis follow the clinical research protocol (PT), compared with the comfort unit,The 24-month disease-free survival rate in TLPLDC treatment group was significantly improved (62.9% vs 34.8%), indicating that the relative risk of disease recurrence was reduced by nearly 50%.

In the population analysis of Intentional Treatment (ITT),There was no significant improvement in 24-month disease-free survival between TLPLDC treatment group and placebo group (38.5%) vs 27%),But in this analysis,The improvement trend of 24-month overall survival rate (OS) was stronger (86.4% vs 75.1%)..

  Kidney Cancer-Ilixadencel Vaccine  

Ilixadencel is an allogeneic dendritic cell (DC) vaccine. Research shows that,Ilixadencel combined with targeted anticancer drug sunitinib(Sotan, common name: sunitinib)First-line treatment of newly diagnosed advanced metastatic renal cell carcinoma(mRCC)Compared with patients treated with sunitinib alone, the total remission rate is doubled, the complete remission rate is higher and the remission is more lasting!

  Glioblastoma-AV-GBM-1 vaccine   On June 8, 2021, well-known foreign biomedical companies announced the release of phase II clinical trial data of their personalized cancer vaccine AV-GBM-1. The research shows that this new vaccine has great potential for prolonging the overall survival of newly diagnosed glioblastoma patients in the medium term. The median progression-free survival time of patients was 10.4 months, which was about 50% higher than the median progression-free survival time of 6.9 months in the landmark STUPP study, and established a nursing standard for newly diagnosed glioblastoma patients.     Non-small cell lung cancer-tedopi vaccine  

On April 1st, 2020, a new anti-cancer vaccine, TEDPI, achieved positive results in the phase III clinical trial of non-small cell lung cancer. After the immune checkpoint inhibitor (PD-1) was resistant or failed, all patients in the group used TEDPI vaccine in the second or third line, and the overall survival rate for one year reached 46%, far exceeding the preset 25%!

A 54-year-old patient with advanced lung cancer has rapidly shrunk (from 39mm to 23mm) after five injections of the new lung cancer vaccine. At the time of reporting, his survival time has exceeded 20.6 months, and he is still being followed up.

06  CIK cell therapy

  CIK cells, that is, Cytokine-Induced Killer (CIK), are a new type of immunocompetent cells, which have strong proliferative ability and cytotoxicity, and have certain immune characteristics. Because this cell expresses both CD3 and CD56 membrane protein molecules, it is also called NK cell (natural killer cell)-like T lymphocyte, which has both the strong anti-tumor activity of T lymphocyte and the non-MHC-limited anti-tumor advantage of NK cell. If NK cells are the "first line of defense" to protect human health, then CIK cells are undoubtedly the "precision missiles" to kill tumor cells. Especially for patients after surgery or radiotherapy and chemotherapy, it can eliminate residual tiny metastatic lesions, prevent cancer cells from spreading and recurring, and improve immunity. Therefore, CIK cells are considered as the first choice for a new generation of adoptive cellular immunotherapy for tumors. Research progress of representative CIK cell therapy     

nasal pharyngeal cancer  

Among 137 patients with nasopharyngeal carcinoma treated by CIK, 50% of them improved their survival time by 6-9 months, and among 137 patients treated by CIK, 50% of them delayed their tumor progression by 6-7 months.

32171650935355613

  liver cancer  

Among the 819 patients with liver cancer treated by CIK, 50% of them improved their survival time by 13~25 months, and among the 819 patients treated by CIK, 50% of them delayed their tumor progression by 4~7 months.

87421650935356226

  ovarian cancer  

Among 72 patients with ovarian cancer treated by CIK, 50% of them have improved their survival time by 24 months. Among 72 cases of ovarian cancer treated by CIK, 50% of ovarian cancer patients delayed their tumor progression by 14.5 months.

91721650935356659

 

carcinoma of colon

Among 126 patients with colon cancer treated by CIK, 50% of them have a longer survival time of 30 months. Among 126 patients with colon cancer treated by CIK, 50% of them delayed their tumor progression by 14.5 months.

81471650935357165

  breast cancer  

The probability that the survival time of 150 breast cancer patients treated with CIK can reach 5 years is increased to 85.7%; The probability of keeping breast cancer from recurring in 150 breast cancer patients treated with CIK within 5 years increased to 72.3%.88231650935357798

  Solid tumor  

Of the 31 patients treated with PD-1 antibody combined with DC-CIK, 2 patients’ tumors completely subsided and 5 patients’ tumors partially subsided. Of the above 7 patients, 6 patients’ effects can be maintained for 5 months. The tumors of the other 13 patients remained stable.

13431650935358461

  renal carcinoma  

Among 43 patients with advanced renal cell carcinoma treated by CIK, 50% of them can delay the tumor progression to 14.7 months.

60351650935359231

07  CAR-M therapy 

In recent years, the study of macrophages has also been paid attention to by the industry. How to activate the anti-tumor activity of these macrophages is the direction that immunologists have been working hard. CD47, an immune checkpoint on macrophages, has become a very promising hot target in the field of tumor immunotherapy.

In a recent study published in Nature Biotechnology, researchers from perelman Medical College of the University of Pennsylvania and other research institutions may have an alternative to T cell therapy to overcome these challenges. Their research shows that genetic modification of macrophages (an immune cell that devours intruders in vivo) may be the key to developing effective cell therapy for solid tumors. They were able to confirm these genetically modified expressions. The macrophages of CAR (CAR-M) can kill tumors in human samples and mouse models in the laboratory and prolong their life.   

81441650935359696   

CAR-M therapy is centered on macrophages, which devour invading cells instead of destroying them like T cells. T cells are more like Space Invaders games, while macrophages are more like Pac-Man games. Another major difference between macrophages and T cells is that they are the first responders of the body to virus infection. Historically, this poses a challenge in trying to genetically modify them to attack cancer, because macrophages are not easily transfected by standard viral vectors used in gene therapy and cell therapy.

In this experiment, the research team used genetic engineering technology to transform macrophages. They not only expressed CAR targeting HER2 antigen, but also were activated and differentiated into M1 macrophage types that promoted inflammation. In this way,These CAR-M cells can not only target tumor cells, but also change the microenvironment near tumors by secreting pro-inflammatory cytokines. They can also present tumor antigens to T cells and activate T cells’ immune response to tumors, which can be described as "killing three birds with one stone".

On March 18th, 2021, Carisma Company of the United States announced the completion of the first drug delivery to the subjects of CAR-M therapy (CT-0508) targeting Her2, marking a new era of CAR-M transformation therapy for solid tumors. In a word, taking macrophages as effector cells transformed by CAR is expected to reverse the tumor inhibitory microenvironment, so as to break through the obstacles of immune cell therapy in solid tumors. 

08  CTL (cytotoxic T lymphocyte) therapy

What cell therapy can be used as an adjuvant therapy for the majority of patients with inoperable advanced cancer? In recent years, researchers have been developing new immunotherapy schemes for these patients, including CTL(cytotoxic T lymphocytes) technology. This technology mainly uses protein, which is unique to cancer cells and has no or low content in normal cells, as bait to select the truly anticancer lymphocytes in peripheral blood, and then further improve and amplify them in vitro, and then return them to patients. MTCA-CTL immunotherapy is a new generation of biological immunotherapy model introduced in China. While ensuring the expansion of non-MHC-restricted killer NK-T cells, directional expansion of HC-restricted CD8++specific CTL cells can make its proportion in cell products reach 60% ~ 70%. The combined effect of this killer cell makes the efficiency of killing tumor cells higher.  

10991650935359999

At present, the multi-target compound antigen peptide biological immunotherapy technology, which is undergoing the second phase of clinical trials in the Cancer Hospital of China Academy of Medical Sciences, is the fifth and brand-new generation of cellular immunotherapy technology, which can optimize the activation method of DC (dendritic cells) to enhance the killing effect of immune cells on tumor cells. At present, it has achieved good clinical results and I believe it will really benefit cancer patients.

Mainly suitable for solid tumors.Head and neck tumor, esophageal cancer, lung cancer, gastric cancer, breast cancer, liver cancer, membranous adenocarcinoma, colorectal cancer, ovarian cancer, uterine cancer, coma cancer, prostate cancer, malignant melanoma, sarcoma and partial malignant lymphoma.

If economic conditions permit and you want to consult MTCA-CTL therapy, you can contact.Cancer-free Home Medical Department (400-626-9916), a detailed assessment of the condition.

09  CAR-NKT therapy

  Natural killer T cells (NKT) are a group of special T cell subsets that express both T cell receptors (TCR) and NK cell receptors on the cell surface, and can produce a large number of cytokines. Such as IL-4 and INFγ. These cells can not only directly dissolve and kill tumor cells, but also play an anti-tumor role through indirect ways (secreted cytokines, activated immune cells, etc.). Recently, a phase I clinical trial jointly conducted by Baylor Medical College in Houston and Texas Children’s Hospital is evaluating a new treatment for children with recurrent neuroblastoma –CAR-NKT cell therapy is expected to break through this bottleneck. Phase I trial, code-named GINAKIT2, used CAR-NKT cells for the first time to treat recurrent neuroblastoma. Eleven children (1~21 years old, with an average age of 7 years old) were all recurrent/refractory high-risk neuroblastoma, with extensive metastasis and no better treatment plan in clinic. The results are very encouraging: Of the 11 advanced patients, The condition of 4 patients was stable, 2 patients achieved partial remission (tumor was obviously reduced), and one of them had complete remission (CR) after receiving the second CAR-NKT cell infusion. In safety, CAR-NKT is safer than CAR-T therapy. No dose-limiting toxicity was observed in the first 28 days after infusion. 

10  Compound immune cell therapy

This technology will alsoSix kinds of cells, such as γδT cells, NK cells, NKT cells, killer T cells, dendritic cells and helper T cells.Activate, multiply 10 million to 20 million cells to 2 billion to 5 billion cells, and then inject them into patients. Cultivating such important immune cells at the same time greatly improves the therapeutic effect compared with single treatment.

Except for some leukemia and malignant lymphoma,It can be used for the treatment of most cancers, and has a good effect in refractory cancer types and advanced cancers. Besides,Compound immune cells also play a great role in improving immunity and strengthening the body.

Xiaobian has something to say

In recent years, due to the development of medical level, new cancer treatment methods have appeared one after another, among which cellular immunotherapy is in full swing, which brings new hope to cancer patients. According to the latest statistics, compared with patients with advanced lung cancer, gastric cancer and liver cancer who only receive surgery, radiotherapy and chemotherapy, adjuvant cellular immunotherapy can prolong the survival time of patients and significantly improve the data effect. In fact, tumor treatment is actually a complex "project", and it is difficult to achieve good results by relying solely on a certain treatment method. Tumor treatment needs the cooperation of various treatment methods to achieve the final victory in the fight against cancer. 

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Huawei Pura 70 all mobile phones are greatly promoted, and JD.COM’s self-operated high-rise is reduced by 1,500 yuan.


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Huawei Pura 70 series mobile phones were launched in April this year, and now the whole department has launched a big promotion activity. The following are the preferential prices of several popular models: 1. Huawei Pura 70: 500 yuan can be reduced under an order, and 300 yuan coupons can be superimposed, so the maximum discount is 800 yuan. 2. Huawei Pura 70 Pro: 800 yuan can be reduced for an order, and 300 yuan coupons can be superimposed, with a total maximum discount of 1,100 yuan. 3. Huawei Pu …

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Hinako Sakurai starred in the Japanese TV series "Bathing Girl" and played a female white-collar worker who loves bathing.

Hinako Sakurai starred in the Japanese TV series Bathing Girl.

People’s Daily Online, Tokyo, July 1st According to the report of Japanese channel comprehensive Japanese fashion entertainment website Modelpress, the Japanese drama "Bathing Girl" will be broadcast on July 15th in the Japanese drama Paravi column of Tokyo TV Station, which will be broadcast at 12: 58 every Wednesday night, starring actress Hinako Sakurai.

The drama tells the story of a female white-collar worker who loves to take a bath at home, Hayashi Nobuyoko, challenging all kinds of bathing methods, looking for "what is the best bathing method" and showing a bathing-centered lifestyle.

Now, influenced by the COVID-19 epidemic, the whole country advocates a new way of life, and the time for people to stay in their own homes is bound to increase. This drama is a series that can be operated in such a home time, with the theme of enjoying a bath. The play is adapted from the comic book of the same name of Shan Hao, which was serialized in the Weekly Big-comics Spirits from 2015 to 2016, and published three volumes of singles. It is a new comic book with the theme of bathing experience.

Sakurai plays the hero, Hayashi Nobuyoko. This is the first time Sakurai has appeared and starred in a TV series of Tokyo TV. Sakurai, who has read the original work, said: "I feel the same way about the comic book, and there are new discoveries. This work expands the possibility of taking a bath and is very interesting. Now because of the COVID-19 epidemic, everyone is looking for a reasonable way to use home time. I think this work is undoubtedly a very meaningful work. "

Screenwriters are Yosuke Masachi, who has been in charge of many late-night TV dramas of Tokyo TV, such as Renting People Who Do Nothing, Death Camp, and Yukori Nakamura, who has written TV dramas such as Metropolitan Police Department Search for a Section Chief and Nepenthes Dream. Directed by Jun’ichi Ishikawa, his main works include TV series Legal High, FRAGILE, movies April Fool’s Day, Love Swing and so on.

The play will premiere exclusively on the video website "Paravi". (Compile: Xue Yixiang Proofreading: Chen Jianjun) (Source:Modelpress)

(Copyright statement: This article is the content of the Japanese entertainment fashion website Modelpress exclusively authorized by People’s Daily Japan Channel. It is forbidden for any organization to use the content and pictures of the article in any form, including but not limited to reprinting and adaptation. )

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For non-emergency medical treatment, please give priority to Internet hospitals.

At the press conference on epidemic prevention and control in Guangzhou on December 6, Zhang Yi, deputy director and spokesperson of Guangzhou Municipal Health and Wellness Committee, reminded the general public that if there is a non-emergency medical need in the near future, please give priority to Internet hospitals or go to primary health care institutions nearby.

According to Zhang Yi, since October 20th, Internet hospitals in Guangzhou have made 270,700 online consultations and issued 15,300 electronic prescriptions, and therapeutic drugs have been quickly delivered to patients by express delivery.

"We have asked medical institutions with Internet hospitals to give full play to the advantages of remote consultation and non-contact medical treatment in Internet hospitals." Zhang Wei said that medical institutions with Internet hospitals will continue to enrich the online diagnosis and treatment power, actively carry out online consultation and improve the drug distribution mechanism; Continuously optimize the online consultation process of fever clinics, respiratory departments, pediatrics, obstetrics and other departments, continuously improve the online consultation experience, ensure sufficient online number sources, standardize online consultation for medical staff, and provide accessible, fast, convenient and safe online consultation, triage and health science services to the public to the maximum extent.

It is reported that at present, all the top three hospitals in Guangzhou have opened Internet hospitals. Almost all hospitals can find Internet hospitals through WeChat WeChat official account, applets, etc. After finding them, they can directly enter the Internet Hospital page of the hospital to register.

Through Internet hospitals, patients can consult online and make follow-up visits without leaving home. Some Internet hospitals can also provide online prescription and express delivery service for patients with chronic diseases.

At present, the epidemic prevention and health guidelines published by several districts sort out the information of Internet hospitals in relevant jurisdictions as follows. Neighborhoods in need can find Internet hospitals in their own jurisdictions as needed and seek online health consultation services.

Haizhu district internet hospital

Wechat applet can log in by searching for the following name:

1. Dr. Ding Bai (Guangdong Second People’s Hospital)

2. zhujiang hospital Internet Hospital of Southern Medical University

3. Guangzhou Red Cross Hospital Internet Hospital

4. Internet Hospital of the Second Hospital of Guangzhou Medical University (the Second Affiliated Hospital of Guangzhou Medical University)

5. Internet Hospital of Integrated Traditional Chinese and Western Medicine Hospital of Southern Medical University

6. Yixian Wisdom Service (Sun Yixian Memorial Hospital of Sun Yat-sen University)

Tianhe district internet hospital

Wechat applet can log in by searching for the following name:

1. Internet Hospital of the Third Affiliated Hospital of Southern Medical University

2. Internet Hospital of the Sixth Affiliated Hospital of Sun Yat-sen University

3. Internet Hospital of the Third Affiliated Hospital of Sun Yat-sen University

4. Internet Hospital of the First Affiliated Hospital of Jinan University

5. Internet Hospital of Zhongshan Eye Center, Sun Yat-sen University

6. Internet Hospital of Guangzhou Twelfth People’s Hospital

7. Internet Hospital of Stomatological Hospital affiliated to Guanghua School of Stomatology, Sun Yat-sen University

8. Guangzhou Women and Children Medical Center Internet Hospital

Baiyun district internet hospital

Wechat applet can log in by searching for the following name:

1. Baiyun District Public Health Internet Consultation Platform

2. The First Affiliated Hospital of Guangzhou University of Chinese Medicine

3. Southern Hospital

Panyu district internet hospital

Wechat applet can log in by searching for the following name:

1. Guangzhou Panyu District Central Hospital Internet Hospital

2. Internet Hospital of He Xian Memorial Hospital, Panyu District, Guangzhou

Huadu district internet hospital

Wechat applet can log in by searching for the following name:

1. Guangzhou Huadu District People’s Hospital Internet Hospital

2. Guangzhou Hospital of Integrated Traditional Chinese and Western Medicine

Huangpu district internet hospital

Wechat searches for the following WeChat official account to log in:

1. "Jianke Doctor" WeChat official account (Qishi Hospital)

2. "Zhongai Medical Companion" WeChat official account (Zhongai Hospital)

3. "Guangzhou Asia-Pacific International Health Examination" WeChat official account (Asia-Pacific Comprehensive Clinic)

Guidelines for internet hospitals in some hospitals

Guidelines for Internet Hospitals of Guangdong Second People’s Hospital

There are more than 600 doctors in the Second People’s Hospital of Guangdong Province who can make online home visits in Internet hospitals, covering 64 departments and AI doctor services. Residents do not need to run to the hospital, they can consult the doctors in the Internet Hospital of the Second Provincial Medical University with one click. After prescribing, they can also choose to circulate the prescription and take medicine outside the hospital.

Entrance 1: "Guangzhou Haizhu Publishing" WeChat WeChat official account

The online consultation platform of "Dr. Ding Bai", the first regional medical and health communication cloud platform in Guangdong, which was jointly established by the Propaganda Department of Guangzhou Haizhu District Committee of the Communist Party of China, Haizhu District Health and Health Bureau and Guangdong Second People’s Hospital, has been officially launched, and has been launched on the WeChat WeChat official account of "Guangzhou Haizhu Publishing".

Use steps:

Step 1: Click to follow "Guangzhou Haizhu Publishing" WeChat WeChat official account;

Step 2: Click "Send Message" to enter the dialogue page;

Step 3: After entering the dialogue page, click "Neighborhood Necessary" → "AI Consultation" to enter the platform, and then click the "Famous Doctors Online" module on the "AI Consultation" page to directly link to "Dr. Ding Bai" in the Internet Hospital of the Second Provincial Medical University.

Entrance 2: Guangdong Second People’s Hospital WeChat WeChat official account

Scan the code to pay attention to the WeChat WeChat official account of the Second People’s Hospital of Guangdong Province. When you enter WeChat official account, click the menu bar, and click Hospital Services-Online Consultation-Online Consultation-Select Doctors. You can find the same clinical specialists as offline, and provide medical services such as consultation, consultation and report interpretation. Doctors write prescriptions online, and drugs can be delivered directly to the door through the prescription circulation platform.

Reminder: Guangzhou medical insurance patients with special needs can make a follow-up visit online at Dr. Ding Bai.

Guangzhou first-class special medical insurance patients can directly make online follow-up visits and make medical insurance settlement.

A class of outpatient patients who have prescribed prescriptions in the offline clinic of the Second Provincial Hospital can find an online doctor to make a follow-up prescription through the "Follow-up Prescription" module in the "Doctor Ding Bai" APP. With your fingers, you can realize the settlement of chronic medical insurance and the delivery of drugs to your home without leaving home, making the operation easier.

In addition to continuing to provide online consultation and home delivery services for patients with chronic diseases and common diseases, the Internet Hospital of the Second Provincial Medical University can also provide related services in COVID-19, such as nucleic acid detection appointment, nucleic acid report inquiry, COVID-19 AI screening, COVID-19 sign reporting, COVID-19 encyclopedia knowledge and COVID-19 policy free consultation, as well as nutrition, psychology, nursing, medication and other specialist consultations and health science education.

Guidelines for Internet Hospitals in zhujiang hospital

In order to further protect the medical needs of patients and reduce the gathering of people, citizens and friends can make one-click operation through zhujiang hospital Internet Hospital and consult experts online.

There are more than 50 visiting specialties in zhujiang hospital Internet Hospital of Southern Medical University, and nearly 400 in-hospital experts make on-line visits, providing services including chronic disease follow-up, specialist outpatient service, specialist nursing, medication consultation, self-help drug purchase in the hospital, and providing services such as Internet diagnosis and treatment, pharmacy service, follow-up management, rehabilitation tracking and health education.

Applicable patients: patients with chronic diseases and common diseases.

Scope of application of medical insurance: patients who have successfully handled the first-class medical insurance in Guangzhou and are in the period of validity.

Applicable diseases of medical insurance: 26 kinds

major function

1. Online follow-up, prescription renewal: zhujiang hospital Internet Hospital applet provides online specialist consultation, follow-up and prescription renewal for chronic diseases and common diseases, and delivers medicines to home without leaving home.

2. Specialized nursing clinic: specialized nursing consultation such as respiratory and critical care medicine, cardiovascular medicine, stroke rehabilitation, peritoneal dialysis, etc.

3. Medication consultation: Professional pharmacists provide comprehensive medication guidance to prevent wrong medication.

4. Nutrition consultation: carry out nutritional intervention and diagnosis and treatment of chronic diseases (diabetes, hypertension, gout, nephropathy, tumor, etc.); Nutrition and weight management during pregnancy; Nutrition consultation for special groups (children, the elderly, pregnant women).

5. Interpretation of physical examination report: Physicians in health management department interpret the physical examination report online to guide in-depth diagnosis and treatment.

6. Carry out health education

7. Self-help drug purchase: Some preparations independently developed by zhujiang hospital can apply for self-help prescription renewal.

Registration telephone number: 4008933900

Consultation time: Monday to Friday from 8: 30 to 12: 00; 13:00-17:00

Guidelines for Internet Hospital of Zhongshan First Hospital

At present, 200+ cloud departments have settled in the Internet Hospital of the First Hospital of Zhongshan, and 1,700+medical staff have made online visits. At the moment of the epidemic, the function of Internet hospital [online expert consultation] allows the majority of patients to stay at home and see a doctor at home.

Citizens and friends use the function of [online inspection appointment] in the Internet hospital, doctors issue inspection items online, patients complete payment online, and make an appointment to go to the hospital for inspection at an appropriate time; After the examination, the patient can check the report results on the mobile phone without going back and forth to the hospital to get the report.

Through the [internet plus Nursing] function, patients with mobility difficulties can receive professional medical care services at home, and the on-site nurses follow the standard service process and have a strict nursing quality and safety supervision and training system.

The function of Internet Hospital of Zhongshan No.1 Hospital [Follow-up for Chronic Diseases] makes the patients who return to the hospital no longer have to go to the hospital, queue up for a long time, and find a doctor. Just select the past prescription in the last three months on the mobile phone, and the medicine can be renewed with a click, and the medicine will be delivered to the door by courier.

In addition, the Internet Hospital of the First Hospital of Sun Yat-sen relies on multi-disciplinary professionals to gather the wisdom of experts in various disciplines and form an all-round and professional diagnosis and treatment model. The patient can make an appointment online through mobile phone. After the doctor accepts and understands the condition, he can organize multidisciplinary experts to discuss the case and provide patients with a personalized and efficient diagnosis and treatment plan.

The Internet Hospital of the First Hospital of Zhongshan can also provide free consultation service for patients with fever and patients who have questions about COVID-19. Just fill in the questionnaire, personal symptoms, medical history and other information, and upload relevant examination pictures, and you can make an appointment with experts for consultation for free. And through the function of COVID-19 nucleic acid billing, citizens can make their own billing with one-click appointment and go to the hospital for COVID-19 nucleic acid testing.

Guidelines for Internet Hospital of Guangzhou First People’s Hospital

1. Pay attention to the WeChat service number and choose the expert consultation service.

① Pay attention to the WeChat service number of [Guangzhou First People’s Hospital], click Outpatient, enter the [Internet Hospital] applet, and select [Online Outpatient] or [Medical Insurance Outpatient];

Directly scan the sunflower code of the Internet Hospital of Guangzhou First People’s Hospital, enter the applet, and select [Online Clinic] or [Medical Insurance Clinic];

(2) select departments and doctors, enter the doctor’s home page, click on the "expert consultation"-"consultation now".

2. Read and check the Informed Consent, add the patient, fill in and upload the disease-related information.

① Add patients, up to 5 people; (2) Choose the purpose of consultation, fill in the description of the illness, and upload relevant information about the patient’s treatment. ③ Pay the consultation fee and wait for the doctor’s reply.

3. The doctor communicates with the patient online (the order is valid within 48 hours after submission, and the doctor will receive the consultation as soon as possible. )

4. Doctors prescribe drugs, patients pay orders and fill in the address accurately, and drugs are delivered home by logistics.

Tips:

1. For the sake of medical safety, the current online diagnosis and treatment of "Internet Hospital" is limited to patients with common diseases and chronic diseases, and it is not suitable for patients who are newly diagnosed, acute, dangerous, severe, chronic diseases, colds and fever. Children patients need to be accompanied by their guardians to complete the appointment.

2. When your condition changes or there are other conditions that are not suitable for online diagnosis and treatment, it is recommended that you go to the nearest medical institution in time to avoid delaying your condition.

3. The doctor will receive the consultation within 48 hours, and the overtime system will automatically refund the fee. Warm reminder: experts use off-hours to provide online diagnosis and treatment services for patients. Please wait patiently for the expert’s reply and thank you for your cooperation.

4. If you are eligible for the medical insurance for employees in Guangzhou and the insured persons with specific diseases in the first-class outpatient clinics of urban and rural residents in Guangzhou, please choose the medical insurance clinic and tell the doctor to prescribe medical insurance, and you can use WeChat medical insurance to settle the order.

5. After the prescription is issued, the patient needs to complete the payment within 72 hours, and the overtime prescription will automatically become invalid.

6. At present, the method of taking medicine only supports logistics distribution, and the courier fee is paid. Once the medicine is delivered from the warehouse, if there is no quality problem with the medicine, it will not be returned. Please do a good job in drug acceptance when receiving the courier. At present, the distribution scope of drugs in Internet hospitals in our hospital covers the epidemic control area. If there is any problem in the distribution of drugs in relevant areas, we will communicate with patients in advance, and the distribution time of drugs affected by the epidemic will be delayed. Please understand.

7. Hospitals can provide invoices for online consultation fees and drug fees. If invoices need to be printed, they can be downloaded and printed at the "Electronic Invoice" on the homepage of the "Internet Hospital" applet.

8. The Internet Hospital of the First Hospital of the City will carry out free online free clinic activities from time to time, and experts from different disciplines will sit in the "cloud" to provide free online consultation services for everyone.

Guidelines for Internet Hospitals in the Second Hospital of Guangzhou Medical University

According to the introduction of the Second Affiliated Hospital of Guangzhou Medical University, there are more than 500 medical staff who take turns to go online to the Internet Hospital, providing online consultation, cloud consultation, medical insurance for chronic diseases, nursing consultation, etc. In addition to serving general health consultants, online services are also provided for patients with chronic diseases who need follow-up visits, patients whose condition is stable after surgery, and people who need to know about nursing and rehabilitation methods when they encounter physical discomfort or illness changes during their stay at home.

Citizens and friends can pay attention to WeChat official account, the Second Affiliated Hospital of Guangzhou Medical University, and choose the menu "Patient Service-Internet Hospital" to enter the Internet hospital, or search for the applet "Patients in the Internet Hospital of the Second Affiliated Hospital of Guangzhou Medical University" or scan the QR code of the Internet hospital applet to enter directly.

On-line consultation improves the consultation efficiency.

Online consultation, some patients will politely say hello to the doctor and ask if the doctor is in. The doctor didn’t answer for a while, and when the doctor is free, he will reply "Hello, yes, what can I do for you?" The patient may have left the internet clinic again. Once and for all, the whole consultation time will last for a long time.

How to improve the consulting efficiency? Experts from the Internet Hospital of the Second Hospital of Guangzhou Medical University gave advice. When asking questions, describe the condition as clearly as possible, and explain clearly the beginning and duration of symptoms. If you have relevant pictures or inspection reports, you can also send them to the consulting doctor.

Drug distribution zhiduo d

Prescriptions issued before 5: 00 on working days will be sent by SF Express before work on the same day. See SF Express Delivery System for the specific receiving time. Prescriptions written after 5 o’clock will be sent before work on the next working day.

Please confirm the mailing address before the patient replenishes the prescription, so as to avoid delaying medication due to distribution reasons. Patients in the middle and high risk control area can ask the resident volunteers to pick them up at the No.1 special window of the Western Pharmacy of the Second Hospital of Guangzhou Medical University.

Text finishing/Guangzhou Daily Xinhua City Reporter: Weng Shuxian