标签归档 武汉桑拿会所

通过admin

Late-night construction also brings dust rolling? These problems that plague people’s lives have been …

Original title of this article: "Does the construction in the middle of the night bring dust rolling? These problems that plague citizens’ lives have been dealt with! 》

Dear friends,

The weekly [Echo] is coming again!

The mixer truck raises dust and the construction noise at night is loud?

Lack of road control, there are great security risks?

The school gate will be flooded whenever it rains, making it difficult to pass?

……

This week’s [Echo]

Continue to solve your problems!

reply

(No.39, 2018)

???

01

User message content

Longxi Mountain, Gaoyao Country Garden, rushed to work day and night, and 2 tons of cars were forbidden to pass through this section. The mixer still shuttled through Cologne Street at 2 or 3 in the morning, raising a lot of dust, and did not sprinkle water on the road to reduce dust, which had a great impact on the life and travel of nearby residents. The dust was rolling during the day and the noise was constant at night. I hope the relevant departments would pay attention to it.

Gaoyao district Committee office

answer

After verification, netizens reported that the situation was true. The construction unit has implemented water spraying and dust removal, but the frequency is not enough, and the dust removal effect is not ideal.

On October 26th, a joint working group was formed by the departments of housing, construction, environmental protection, transportation and traffic police in our district. The person in charge of the Longxi Mountain construction project in Country Garden and the person in charge of the construction unit were interviewed, and the situation reflected by the netizens’ messages was reported to the person in charge. The project construction party was required to strictly abide by various rules and regulations to carry out construction and production according to law, reasonably arrange the construction time, and limit the impact of environmental pollution problems such as dust and noise on the surrounding residents to the greatest extent. It is strictly forbidden to overload and carry vehicles. That night, traffic, traffic police and other departments set up cards around "Country Garden Longxi Mountain" to enforce the law, and rectified the traffic violations of dump trucks, and the rectification action received certain results.

On October 27th, the working group formed a rectification plan on relevant issues as follows:

First, it is forbidden for the construction unit to carry out construction at night (from 22:00 pm to 6:00 am the next day), and the District Housing and Construction Bureau is responsible for supervision. If the construction at night is found, it will be ordered to stop work immediately for rectification.

Second, because the traffic of trucks over 2 tons is restricted in Cologne Street, construction vehicles must bypass the construction site through other roads to avoid dust and noise disturbing people, and the traffic police and transportation departments are responsible for supervision; The District Traffic Police Brigade carries out technical maintenance and upgrade of monitoring equipment in Cologne Street, and the District Transportation Bureau urges the owner to install weighing equipment at the cargo loading site and assign special personnel to manage it.

Third, the construction unit is required to increase the frequency of sprinkling water to reduce the dust on the road section, and the district environmental protection bureau is responsible for supervision.

In the next step, housing, construction, environmental protection, transportation and other departments will establish a linkage mechanism, strengthen joint law enforcement, conduct night inspections, and severely punish violations found. The traffic police department will implement the service system and increase the patrol monitoring of this section by setting up cards and taking irregular measures.

02

User message content

1. On the Hengda Haoting section of Dinghu 321 National Road, even if you can enter the auxiliary road after turning around from west to east, there is no municipal road that can turn into Hengda Haoting. Every day, many people from Duanzhou to Dinghu turn around here and then take the path next to the gas station to enter Hengda Haoting Road. Because it is not a municipal road, the road surface is not maintained and there is no safety control, which has great security risks. It is recommended to improve it!

2. Since the construction of National Highway 321, Xinyuan No.1 Street in Dinghu District has been flooded in every heavy rain, especially when typhoons such as Tiange and Mangosteen arrive, and even the flooding depth is more than 1 meter. The surrounding residents have repeatedly reported their problems to the petition offices and sub-district offices, but they have not received any reply or rectification.

Dinghu district Committee office

answer

(I) About the problem of netizens reflecting the section of Evergrande Haoting.

It is understood that the path that enters Taihe gas station after the U-turn of Hengda Haoting section of National Highway 321 is not a municipal road, but is owned by the gas station. The person in charge of the commercial gas station has no intention to maintain the path at present. Next, our district will strengthen the safety supervision around this section in conjunction with the traffic police department to ensure the travel safety of surrounding residents.

(2) About netizens reflecting the flooding problem in Xinyuan Street.

It is understood that due to the influence of Typhoon Mangosteen No.22 this year, from September 16 to 18, heavy rain continued to fall in our area, with local heavy rain, and the maximum rainfall recorded at Kengkou was 269 mm. Xinyuan First Street was one of the areas where flooding occurred.

During Typhoon Mangosteen, the rainfall lasted for a long time and was heavy, which greatly exceeded the design capacity of urban sewers and drainage standards, making it difficult to drain the rainwater on the pavement in a short time, and flooding occurred in many places in the area to varying degrees. Xinyuan 1st Street mentioned in the letter must be flooded in heavy rain after the construction of National Highway 321. The reason is that the elevation of the road surface has been improved after the urbanization of National Highway 321, which makes Xinyuan 1st Street relatively low-lying and prone to flooding.

In view of this situation, our district will speed up the construction progress of Xinshengtian Canal, complete the project construction as soon as possible under the premise of ensuring the quality, and strive to put it into use as soon as possible, so as to reduce the drainage pressure of urban sewers and reduce the flooding problem during the torrential rain in the district. In addition, the water department of our district has organized the construction team to comprehensively clear the municipal sewers of Xinyuan First Street and surrounding roads to ensure the smooth drainage of sewers in this area. In the next step, our district will refer to the vertical of surrounding roads and other factors, and appropriately adjust the ground elevation of Xinyuan Street to minimize the problem of road surface water accumulation.

03

User message content

1. The road at the gate of xinhua primary school will be flooded whenever it rains, and the water depth is more than 20 centimeters. Primary school students cannot pass after school, so parents need to carry it. I hope the relevant departments will go to the field to investigate and study solutions.

2. Two fans on the Blue Sky Water Gathering Building of Duanzhou Shanghai City Phase II roared for 24 hours. Standing on the balcony, I felt my ears tingle. I didn’t even dare to open the doors and windows at home. I couldn’t sleep when I opened the windows. I have reported to various departments that no one has handled them many times. Blue Sky Shuihui is a clubhouse, which is opened so close to the community. It is not legal at all. A few days ago, I heard the voice of singing K in the middle of the night.

Duanzhou district government office

answer

(1) About the problem that netizens report that the road at the entrance of xinhua primary school will be flooded when it rains.

According to the field investigation, xinhua primary school is located on the land on the east side of Xinghu Avenue and the north side of Donghu Road, which is lower than the municipal roads. The road at the entrance of xinhua primary school belongs to the village road, and drainage pipes and wells have not been built around it. The urban drainage network management center regularly cleans and maintains the municipal drainage pipelines of Xinghu Avenue and Donghu Road to keep the pipelines unblocked. However, due to the lack of supporting drainage facilities and municipal drainage pipelines around xinhua primary school, and the fact that it is located in a low-lying area, rainwater cannot be drained when it rains, so it is easy to form flooding in rainy days. Our district has urged Huanggang Sub-district Office to organize Fenggang West Village to do its best to do the pumping and drainage work of this section in rainy days, and dredge the drainage channels to reduce the impact of stagnant water.

As the north side of xinhua primary school is reserved land for the expansion of Honghu Lake, it will be built by the Municipal Construction Bureau. The next step in this area will be drainage planning and construction together with Honghu Lake, which is transferred to the east. After the drainage network in this area is improved, the flooding problem of the road at the entrance of xinhua primary school can be completely solved.

(B) About the problem that netizens reported that the noise of Shanghai Blue Sky Water Club Phase II disturbed people.

Upon investigation, the name of the place mentioned in the complaint is Duanzhou Blue Sky Holiday Leisure Center (hereinafter referred to as "Blue Sky Shuihui Club") registered in the administrative department for industry and commerce. Duanzhou Sub-bureau of City Comprehensive Law Enforcement Bureau received a report on the disturbance caused by the fan noise of Blue Sky Shuihui Club in early June. After repeated urging by law enforcement officers on June 8, July 11, July 17 and August 6, the club moved two fans on the roof that were originally close to residential buildings to the direction of the road, and connected the extended air ducts of the fans to the sound isolation box, which significantly reduced the noise.

According to the situation reflected by netizens, Duanzhou Branch of the Municipal Comprehensive Law Enforcement Bureau and the District Cultural and Sports Bureau sent law enforcement officers to the scene for mediation. On-site inspection found that in order to reduce noise and avoid noise spread, the club also closed the kitchen window. On the morning of October 10th, law enforcement officers contacted the relevant complainants by telephone to inform them of the handling situation and will monitor the noise of Blue Sky Holiday Leisure Center together with the municipal environmental monitoring station. The complainant expressed satisfaction and understanding of our work.

In the next step, our district will urge Duanzhou Branch of the Municipal Comprehensive Law Enforcement Bureau and the Municipal Environmental Monitoring Station to monitor the noise of the clubhouse as soon as possible, and follow up according to the monitoring report.

04

User message content

The industrial zone on the west side of Xiangang Toll Station often uses night time to secretly discharge harmful waste gas and smoke, which causes people living nearby to have difficulty breathing and seriously affects their health! We have repeatedly complained ineffectively, and now we question whether there is a problem with the efforts of the functional departments to implement the national environmental protection policy.

Gaoyao district government

answer

Recently, the environmental protection bureau of our district has received two complaints about the waste gas pollution in the industrial zone on the west side of the Xian Gang toll station, which the district environmental protection bureau attaches great importance to. Since the beginning of this year, in response to the problem of waste gas pollution in Xiangang Industrial Zone, the District Environmental Protection Bureau has repeatedly conducted surprise inspections with the People’s Government of Xiangang Town on enterprises in the industrial zone, and filed investigations on 14 enterprises with environmental violations, which severely cracked down on environmental violations of enterprises in the region. At the same time, since the creation of our district, the government of Xiangang Town has established a grid system, strengthened supervision and inspection of enterprises in the industrial zone, and required relevant enterprises to implement the environmental management system.

After receiving complaints from the masses, on the evening of October 10, 2018, the law enforcement officers of the District Environmental Protection Bureau, together with the staff of Gaoyao District Environmental Protection Monitoring Station and third-party testing institutions, went to the complaint area to conduct supervision and inspection, and sampled and monitored the ambient air at the northeast side (near the exit of the toll station), south side (in the junior middle school) and west side of the complaint area, and will focus on tracking and inspecting the enterprises near the relevant area according to the results of the ambient air monitoring report.

At the same time, the enterprises involved in waste gas emission and producing at night (Zhaoqing Gaoyao Hongzhan Hardware Plastic Co., Ltd., Chongqing Gaoyao Jinyi Aluminum Co., Ltd., Zhaoqing Gaoyao Zhaoxing Industry and Trade Co., Ltd., etc.) were monitored for waste gas. During the inspection, law enforcement officers found that the exhaust gas collection in the drawing and granulating workshop of Hongzhan Hardware & Plastic Co., Ltd. in Gaoyao District of Zhaoqing City was not perfect and the workshop was irritating, so they immediately asked the company to stop production and rectify. The next day, the district environmental protection bureau issued a notice to the company to stop production and rectify, requiring the company to resume production after the rectification is completed and reported to the bureau for inspection.

In the next step, the District Environmental Protection Bureau will continue to strengthen the supervision and inspection of gas-related enterprises in the industrial zone on the west side of the Xiaogang toll station, and intensify inspections. Once suspected environmental violations are found, they will be seriously investigated and dealt with according to law. At the same time, the district environmental protection monitoring station and third-party testing institutions are required to increase the frequency of spot checks and monitoring of gas-related enterprises near the complaint area, and investigate the enterprises suspected of exceeding the standard discharge according to law.

That’s all for this issue.

If the neighbors have problems to reflect

Then leave us a message ~

Please ask the neighbors to reflect the problems in the [Suggestions] column with evidence and facts, otherwise it will easily lead to a waste of public resources. Thank you for your support!

How to leave a message?

It’s in the "Opinions and Suggestions" column of "Zhaoqing Release"

?

For some netizens’ suggestions with clear views, true information, focusing on a single theme and relative depth, they will be selected separately and submitted to the relevant leaders of the municipal party Committee and municipal government for reference.

To netizens

We will continue to increase the tracking efforts.

Answer your question with [Echo]

At the same time, we will continue to pay attention to the follow-up handling.

Welcome the general public to supervise!

Zhaoqing fafa editorial department

Data collation Cai Tingting

Trainee editor Mo Sha

Editor-in-Chief Tang Qianyu

Editor Zeng Shanjie

Please indicate if the article is reproduced.

From "zhaoqingfabu"

Previous article recommendation

?

?

通过admin

Is cell therapy reliable in treating cancer? CAR-T leads the world, and 10 popular and emerging cellular immunotherapy show their magical powers!

The incidence of malignant tumor is increasing year by year, which has become a common problem faced by human beings. Traditional treatment methods such as surgery, traditional chemotherapy and radiotherapy have always played a leading role in cancer treatment, but the effects of these treatments are limited. In particular, it is difficult for advanced patients to benefit from these treatments for a long time, nor can they fundamentally solve or change their quality of life. Therefore, researchers are increasingly focusing on the field of immunotherapy. Immunotherapy has brought new opportunities and hopes for the treatment of tumors, among which Immunocheckpoint inhibitors, therapeutic antibodies, tumor vaccines, immunomodulators, adoptive cell therapy, etc. Significantly improved the prognosis of cancer patients, and some patients with advanced cancer obtained long-term survival. In the past two years, many cellular immunotherapy have emerged and developed rapidly, which undoubtedly set off a wave of cancer treatment. So, is cell therapy reliable in treating cancer? In fact, immunotherapy has a history of more than 100 years, and it has only gradually entered the public’s field of vision in the last two years, and it has been absolutely recognized by the world oncology community.   

20731650935352411   

A milestone in the history of cancer immunotherapy In 2013, Science magazine ranked the top ten scientific breakthroughs of the year, and immunotherapy topped the list. In recent years, immunotherapy is one of the hot spots in the research field of tumor treatment at home and abroad, and a large number of clinical studies have shown exciting results. Among them, Cellular immunotherapy uses the self-protection and killing ability of human immune system to achieve anti-tumor effect. Cells with immune function in patients are cultured and proliferated in vitro, and they are given the ability to attack tumor cells by technical means, and then they are imported into patients to realize their own anti-cancer. This therapyAgainst immune cells, not cancer cells.It is not as harmful to the patient’s health as surgery, radiotherapy and chemotherapy. Patients with early cancer can be treated directly, especially with the attack on residual cancer cells after surgery. Judging from the rapid development in scientific research and clinic in recent years, cellular immunotherapy is expected to become the fourth pillar of anticancer therapy in terms of accuracy, effectiveness and safety. Next, the small series of Cancer-free Home gives a general introduction and inventory of a variety of popular and emerging cellular immunotherapy in the biomedical industry, hoping to give cancer friends a general understanding of the general development process of this cancer treatment field. 

0one  CAR-T cell therapy

CAR-T therapy is chimeric antigen receptor T cell immunotherapy, which is a new precise targeted therapy for treating tumors. T cells are activated by genetic engineering technology, and the positioning navigation device CAR (tumor chimeric antigen receptor) is installed to transform the ordinary "warrior" of T cells into "super warrior" CAR-T cells, Specially identify tumor cells in vivo and kill tumor cells efficiently. So as to achieve the purpose of treating malignant tumors. At present, with 2021, Aquilencel injection, Regioscel injection. It was approved for listing in China, in 2022.Cedarchiorense was approved for listing by FDA.CAR-T therapy is expected to enter the blowout period. Indeed, CAR-T technology has shown good curative effect in many hematological tumors, such as leukemia, lymphoma and multiple myeloma, and more than half of hematologic cancer patients who are on the verge of despair and have no cure have achieved good curative effect.  

29751650935353293

CAR-T cell therapy has been listed at home and abroad at present.

Although the clinical effect of CAR-T therapy on solid tumors is not satisfactory, and it has even been sung down by some people, in recent years, CAR-T therapy has made outstanding progress in the fields of gastric cancer, liver cancer and pancreatic cancer. Scholars at home and abroad have made various modifications to CAR-T, and constantly found new targets for the treatment of various solid tumors.    

Clinical study on CAR-T therapy is out of the loop.

0one Gastric cancer and pancreatic cancer As the first CAR-T cell targeting Claudin18.2 in the world, CT041 emerged as early as the ASCO annual meeting in 2019. At that time, the total objective remission rate was 33.3%, which already surprised the world. Now the more remarkable curative effect is undoubtedly the icing on the cake! This clinical data shows a good treatment prospect for digestive system tumors!

Domestic CAR-T therapy CT041 first appeared in ESMO

Developed by Keji Pharmaceutical at the annual meeting of the European Society of Oncology (ESMO) in 2021.Targeting Claudin18.2(CLDN18.2)Autologous CAR-T candidate productsCT041Showing its presenceDigestive system tumorThe outstanding curative effect can be described as brilliant!

The research data is particularly eye-catching!

1. All patients’The objective remission rate was 48.6%, and the disease control rate was 73%.All patients with gastric cancerThe total objective remission rate was 57.1%.

2. Patients with gastric cancer who failed to receive at least 2 lines of treatment in the past:The objective remission rate was 61.1%, and the disease control rate was 83.3%.

3. And the overall tolerance is good!

As of March 3, 2022,CT041 became the first and only CAR-T cell candidate product in the world for the treatment of solid tumors, which entered the confirmatory phase II clinical trial.This is a milestone for CAR-T to conquer the solid tumor field. Congratulations!

In addition, there are many CAR-T cell therapies targeting CLDN18.2.0 2 liver cancer At present, the clinical trial targets of CAR-T in the treatment of liver cancer are mainlyGPC3 (phosphatidylinositol proteoglycan 3). The breakthrough research results completed by Professor Zhai Bo, director of the Department of Tumor Interventions, Renji Hospital affiliated to Shanghai Jiaotong University School of Medicine, were published in the international authoritative journal Clinical Cancer Research on May 5, 2020. By July 24th, 2019, 13 patients had received CAR-GPC3 T cells with a median value of 19.9×108. All the patients are GPC3 positive, and they have received surgical treatment, local treatment or systemic treatment, and they all carry hepatitis B virus (HBV). Two patients achieved partial remission (PR). The 6-month, 1-year and 3-year survival rates of all patients were 50.3%, 42.0% and 10.5% respectively, and the median survival time (OS) was 278 days (39.7 weeks). At the ASCO annual meeting in 2021, Chinese medical researchers published the latest clinical research data of CAR-T drug targeting GPC3 (Ori-CAR-001) in the treatment of recurrent/refractory hepatocellular carcinoma for the first time. As of March 10, 2021, a total of 11 recurrent subjects who received cell infusion were included.All the subjects had advanced hepatocellular carcinoma, and none of them were effective after chemotherapy, TACE (transcatheter arterial chemoembolization) and targeted therapy.Of the 9 evaluable subjects,4 cases achieved partial remission (PR), 3 cases achieved disease stability (SD) and 2 cases developed disease progression (PD).The objective remission rate was 44%, and the disease control rate reached 78%.. 

02  Treatment of tumor infiltrating lymphocytes (TIL)

TILs therapy, simply speaking, is to separate and purify the lymphocytes in the tumor tissue after surgery, select the lymphocytes that can specifically resist cancer, and then amplify and activate them and reinfusion them. This kind of therapy has a history of more than 30 years, and it was first used for malignant melanoma. In recent years, it has given good data in many solid tumors such as cervical cancer and lung cancer.

This therapy is equivalent to pulling back veterans with combat experience directly from the battlefield. After a round of "political review" and "big competition" in professional ability, the spies and traitors are eliminated as far as possible, leaving the ones with the strongest fighting capacity, providing supplies, and then sending them back to the battlefield to continue fighting. Looking at the whole industry, the voice of "innovative therapy based on Tiles cells LN-144 (Lifelecel) is expected to be approved in 2022" is particularly loud. Tiles therapy, as an "ancient" cell therapy, is expected to usher in the first approved product this year, and its great potential in treating solid tumors can not be underestimated, with strong strength and relatively "out of the circle". TILs domain key node event     In 1982  

Steven A.Rosenberg and others discovered for the first time that TILs can inhibit the metastasis of melanoma cells in patients.

  1988  

The earliest attempt of TILs in clinical treatment: TILs therapy for metastatic melanoma achieved an objective remission rate of 60%.

  In 2011  

Steven A.Rosenberg and others published a phase II clinical research data in Clinical Cancer Research: the objective remission rate (ORR) and complete remission rate (CR) of patients with melanoma treated by TILs were 56% and 24% respectively.

  In 2012  

Melinda Bachini, a patient with advanced intrahepatic cholangiocarcinoma, is called the first patient to achieve complete remission (CR) after TILs therapy.

  2019  

At the ASCO meeting, the clinical results of innovative therapies LN-145 and LN-144(Lifileucel) based on TILS cells in the treatment of cervical cancer and melanoma have attracted wide attention in the medical field.FDA awarded LN-145 breakthrough therapy recognition.

  In 2021  

Phase I clinical results of TILs cell therapy at AACR meeting: among 12 evaluable patients.Non-small cell lung cancer patientsMedium,TIL therapy can achieve a total remission rate of 25%, among whichTwo patients achieved lasting complete remission.

  In 2021  

At the annual meeting of tumor immunotherapy association (SITC), the clinical research results of LN-145 in the treatment of metastatic non-small cell lung cancer (mNSCLC) showed that in 28 cases,In patients with recurrent/refractory mNSCLC,After LN-145 monotherapy,The overall remission rate (ORR) was 21.4%(1 case of CR and 5 cases of PR, including 2 cases of PD-L1 negative tumors), 12 cases were stable, and the disease control rate (DCR) was 64.3%.

03  TCR-T therapy

CAR-T cells and TCR-T cells belong to T cells modified by genetic engineering technology.Compared with CAR-T therapy, TCR-T therapy has unique advantages in the field of solid tumor treatment. TCR-T cell therapy can identify tumor-specific antigens from cell membrane surface or intracellular sources, and has entered clinical application from the initial basic immune research, showing initial efficacy in solid tumors, and has become the most likely T cell immunotherapy to make a breakthrough in the field of solid tumors! 

1、 TCR-T cell therapy in China has been approved for clinical use and has become a potential new therapy for HBV-related hepatocellular carcinoma!

At present, in addition to the global TCR-T in full swing in the research and development and clinical verification stage, China is also constantly breaking through innovation.

On December 22nd, 2021, CDE (Drug Evaluation Center) official website was able to inquire about the clinical application of "SCG101 Autologous T Cell Injection", which is a TCR-T cell therapy for specific hepatitis B virus (HBV) epitopes and a potential new therapy for HBV-related hepatocellular carcinoma (HCC).

2881650935354255

▲ Image source: CDE official website

2、 Advanced liver cancer ushered in a new dawn! TCR-T therapy makes cancer patients completely relieved.

As early as 2020 International Hepatology Conference (ILC), ADP-A2AFP, a new TCR-T therapy for liver cancer based on T cells, caused quite a stir, and also made a new breakthrough in the new therapy for liver cancer.

Among the included patients,One patient showed a complete remission (CR) in cancer progression, and the AFP of the other participants also decreased to varying degrees.This means that the experiment has made progress, and it also shows that this therapy is effective for the treatment of advanced liver cancer.

             

10051650935354424

All the 9 patients involved had undergone surgery and conventional radiotherapy and chemotherapy, but failed or became intolerant. Among the 4 patients who received the highest dose of treatment,One patient achieved complete remission, and CT scan showed that all the lesions in the patient disappeared, and it has lasted for more than half a year without any recurrence!

The best response of other patients (cohort 1, cohort 2) is stable. 1 patient in queue 2After one month of treatment, the volume of the primary lesion did not decrease, but the volume of mediastinal lymph node metastasis decreased obviously!       

39351650935354669

Therefore, TCR-T therapy targeting AFP (alpha-fetoprotein) can kill tumor cells expressing AFP. Based on the positive results of this study, researchers are expected to expand the maximum dose to 5 billion cells, and we look forward to the publication of updated data of this study!

04  CAR-NK therapy

In recent two years, in addition to CAR-T therapy, another new cancer cell therapy- Natural killer (NK) cell therapy It has also gradually attracted attention. The researchers said, NK cell As a cell anticancer therapy, it has more potential, and it may be safer, cheaper and faster. CAR-NK is to add a chimeric antibody to NK cells by genetic engineering that can recognize tumor cells and activate NK cells to kill tumor cells at the same time. 

one   The first "spot" CAR-NK clinical trial in China was approved by the Food and Drug Administration. On November 11, 2021, National Medical Products Administration Drug Evaluation Center passed an independent research and development in China. Mesothelin (MSLN) chimeric antigen receptor NK cells (CAR-NK) injection for the treatment of advanced epithelial ovarian cancer. Application for clinical trial of CAR-NK injection. According to the cancer-free home, This product is the first "spot" CAR-NK product of foreign origin in China. This also marks a new milestone in the research of immune cell drugs in the treatment of solid tumors in China! 

2  The 1-year survival rate doubled, and the curative effect of CAR-NK therapy in solid tumor increased sharply.

Recently, the journal Clinical Oncology Research published a phase II clinical trial for lung cancer. Heat shock protein 70(Hsp70) is highly expressed in about 70% of middle and advanced lung cancer. NK cells are activated by Hsp70 in vitro, which is equivalent to making NK cells meet their future enemies in vitro, "making enemies" first, and then returning them to patients, so that NK cells can formally fight with cancer cells in vivo. This method of stimulating NK cells with antigen peptides in vitro and giving them certain specificity is a hot topic in recent years.

A total of 16 patients with stage III non-small cell lung cancer were enrolled in this clinical trial. One group received traditional chemotherapy combined with radiotherapy and chemotherapy, and the other group received chemotherapy combined with Hsp70 pre-stimulated NK cell reinfusion.

The results show that:The one-year survival rate can be doubled from 33% to 67% by Hsp70 pre-stimulated NK cell reinfusion therapy combined with traditional radiotherapy and chemotherapy, and the preliminary results are encouraging.

Next, Xiaobian shows a typical successful case in combination therapy, as shown in the figure:After 1~2 months of treatment, the lung tumor completely disappeared and the curative effect has been maintained for 18 months.

  85441650935355029   

In addition to the above-mentioned clinical studies at home and abroad, CAR-NK cells also have a good effect on glioblastoma and neuroblastoma, specifically recognizing and killing breast cancer cells with high efficiency, and have a remarkable effect on multiple myeloma.

05  Dendritic cell vaccine

Cancer vaccine is a form of immunotherapy, which can prevent cancer from developing or kill existing tumors by stimulating or restoring the human immune system. Dendritic cell (DC) vaccine is a new biological therapy for malignant tumor in recent years, which has been paid more and more attention and recognized by oncologists. As an important member of the human immune defense system, Dendritic cells have the strongest antigen presenting function and are known as "sentinels" of the immune system. It is named because its cells extend outward with many dendritic protrusions. It mainly uses modern high-tech biotechnology to collect the peripheral blood of tumor patients, induce and cultivate a large number of dendritic cells in a short time in vitro, and equip them with immune cells that patients do not have, so as to accurately "target" and kill cancer cells. Not only that, It can also induce immune memory in patients, so that patients can obtain long-term anti-cancer effect.

DCVAC/LuCa is a dendritic cell vaccine developed by the United States for patients with non-small cell lung cancer.In a study on the first-line treatment of advanced lung cancer announced at the ASCO conference in 2019, DCVAC/LuCa vaccine combined with chemotherapy groupThe objective remission rate is 45%,The median overall survival time was 15.5 months, and the median progression-free survival time was 6.74 months.Reduce the risk of death by 46%!

In the Phase II clinical study of the latest novel dendritic cell vaccine DCVAC/LuCa (lung cancer dendritic cell vaccine) combined with standard carboplatin/pemetrexed in the treatment of advanced non-squamous cell (nsq) non-small cell lung cancer in 2022,The 1-year survival rate was 72.73% and the 2-year survival rate was 52.57%.By the time the data was published, the median overall survival time had not been reached. The median progression-free survival time was 8.0 months, and the objective remission rate was 31.82%.

  Prostate cancer-Provenge vaccine  

Provenge is the first vaccine approved for treatment in the United States, which initiated a new era of cancer immunotherapy.This is an autologous cell immunotherapy, which was approved by FDA on April 29, 2010 to treat asymptomatic or mild mCRPC. This approval marks the success of 20 years of unremitting efforts.In the United States, Provenge is the only FDA-approved immunotherapy for prostate cancer made from patients’ own immune cells.

  Ovarian cancer-dcvac/ovca vaccine  

At the 50th annual meeting of the Society of Gynecological Oncology (SGO) in 2019, the final result of SOV02, a phase II clinical trial, was announced: DCVAC/OvCa, an immunotherapy based on dendritic cells, was added to standard carboplatin and gemcitabine schemes for patients with recurrent, platinum-sensitive and epithelial ovarian cancer.It can prolong the overall survival (OS) of patients with advanced recurrent ovarian cancer by more than one year.andDCVAC/OvCa reduced the death risk of second-line treatment of ovarian cancer by 62%. The overall survival (OS) increased significantly by 13.4 months. The median progression-free survival rate (mPFS) increased by 1.8 months. The global phase III study will be launched soon.

Melanoma-TLPLDC vaccine

The subgroup analysis results of the phase IIb clinical trial of TLPLDC vaccine in the treatment of melanoma were published at the ASCO-SITC Clinical Immunooncology Conference in 2020.

In that population analysis follow the clinical research protocol (PT), compared with the comfort unit,The 24-month disease-free survival rate in TLPLDC treatment group was significantly improved (62.9% vs 34.8%), indicating that the relative risk of disease recurrence was reduced by nearly 50%.

In the population analysis of Intentional Treatment (ITT),There was no significant improvement in 24-month disease-free survival between TLPLDC treatment group and placebo group (38.5%) vs 27%),But in this analysis,The improvement trend of 24-month overall survival rate (OS) was stronger (86.4% vs 75.1%)..

  Kidney Cancer-Ilixadencel Vaccine  

Ilixadencel is an allogeneic dendritic cell (DC) vaccine. Research shows that,Ilixadencel combined with targeted anticancer drug sunitinib(Sotan, common name: sunitinib)First-line treatment of newly diagnosed advanced metastatic renal cell carcinoma(mRCC)Compared with patients treated with sunitinib alone, the total remission rate is doubled, the complete remission rate is higher and the remission is more lasting!

  Glioblastoma-AV-GBM-1 vaccine   On June 8, 2021, well-known foreign biomedical companies announced the release of phase II clinical trial data of their personalized cancer vaccine AV-GBM-1. The research shows that this new vaccine has great potential for prolonging the overall survival of newly diagnosed glioblastoma patients in the medium term. The median progression-free survival time of patients was 10.4 months, which was about 50% higher than the median progression-free survival time of 6.9 months in the landmark STUPP study, and established a nursing standard for newly diagnosed glioblastoma patients.     Non-small cell lung cancer-tedopi vaccine  

On April 1st, 2020, a new anti-cancer vaccine, TEDPI, achieved positive results in the phase III clinical trial of non-small cell lung cancer. After the immune checkpoint inhibitor (PD-1) was resistant or failed, all patients in the group used TEDPI vaccine in the second or third line, and the overall survival rate for one year reached 46%, far exceeding the preset 25%!

A 54-year-old patient with advanced lung cancer has rapidly shrunk (from 39mm to 23mm) after five injections of the new lung cancer vaccine. At the time of reporting, his survival time has exceeded 20.6 months, and he is still being followed up.

06  CIK cell therapy

  CIK cells, that is, Cytokine-Induced Killer (CIK), are a new type of immunocompetent cells, which have strong proliferative ability and cytotoxicity, and have certain immune characteristics. Because this cell expresses both CD3 and CD56 membrane protein molecules, it is also called NK cell (natural killer cell)-like T lymphocyte, which has both the strong anti-tumor activity of T lymphocyte and the non-MHC-limited anti-tumor advantage of NK cell. If NK cells are the "first line of defense" to protect human health, then CIK cells are undoubtedly the "precision missiles" to kill tumor cells. Especially for patients after surgery or radiotherapy and chemotherapy, it can eliminate residual tiny metastatic lesions, prevent cancer cells from spreading and recurring, and improve immunity. Therefore, CIK cells are considered as the first choice for a new generation of adoptive cellular immunotherapy for tumors. Research progress of representative CIK cell therapy     

nasal pharyngeal cancer  

Among 137 patients with nasopharyngeal carcinoma treated by CIK, 50% of them improved their survival time by 6-9 months, and among 137 patients treated by CIK, 50% of them delayed their tumor progression by 6-7 months.

32171650935355613

  liver cancer  

Among the 819 patients with liver cancer treated by CIK, 50% of them improved their survival time by 13~25 months, and among the 819 patients treated by CIK, 50% of them delayed their tumor progression by 4~7 months.

87421650935356226

  ovarian cancer  

Among 72 patients with ovarian cancer treated by CIK, 50% of them have improved their survival time by 24 months. Among 72 cases of ovarian cancer treated by CIK, 50% of ovarian cancer patients delayed their tumor progression by 14.5 months.

91721650935356659

 

carcinoma of colon

Among 126 patients with colon cancer treated by CIK, 50% of them have a longer survival time of 30 months. Among 126 patients with colon cancer treated by CIK, 50% of them delayed their tumor progression by 14.5 months.

81471650935357165

  breast cancer  

The probability that the survival time of 150 breast cancer patients treated with CIK can reach 5 years is increased to 85.7%; The probability of keeping breast cancer from recurring in 150 breast cancer patients treated with CIK within 5 years increased to 72.3%.88231650935357798

  Solid tumor  

Of the 31 patients treated with PD-1 antibody combined with DC-CIK, 2 patients’ tumors completely subsided and 5 patients’ tumors partially subsided. Of the above 7 patients, 6 patients’ effects can be maintained for 5 months. The tumors of the other 13 patients remained stable.

13431650935358461

  renal carcinoma  

Among 43 patients with advanced renal cell carcinoma treated by CIK, 50% of them can delay the tumor progression to 14.7 months.

60351650935359231

07  CAR-M therapy 

In recent years, the study of macrophages has also been paid attention to by the industry. How to activate the anti-tumor activity of these macrophages is the direction that immunologists have been working hard. CD47, an immune checkpoint on macrophages, has become a very promising hot target in the field of tumor immunotherapy.

In a recent study published in Nature Biotechnology, researchers from perelman Medical College of the University of Pennsylvania and other research institutions may have an alternative to T cell therapy to overcome these challenges. Their research shows that genetic modification of macrophages (an immune cell that devours intruders in vivo) may be the key to developing effective cell therapy for solid tumors. They were able to confirm these genetically modified expressions. The macrophages of CAR (CAR-M) can kill tumors in human samples and mouse models in the laboratory and prolong their life.   

81441650935359696   

CAR-M therapy is centered on macrophages, which devour invading cells instead of destroying them like T cells. T cells are more like Space Invaders games, while macrophages are more like Pac-Man games. Another major difference between macrophages and T cells is that they are the first responders of the body to virus infection. Historically, this poses a challenge in trying to genetically modify them to attack cancer, because macrophages are not easily transfected by standard viral vectors used in gene therapy and cell therapy.

In this experiment, the research team used genetic engineering technology to transform macrophages. They not only expressed CAR targeting HER2 antigen, but also were activated and differentiated into M1 macrophage types that promoted inflammation. In this way,These CAR-M cells can not only target tumor cells, but also change the microenvironment near tumors by secreting pro-inflammatory cytokines. They can also present tumor antigens to T cells and activate T cells’ immune response to tumors, which can be described as "killing three birds with one stone".

On March 18th, 2021, Carisma Company of the United States announced the completion of the first drug delivery to the subjects of CAR-M therapy (CT-0508) targeting Her2, marking a new era of CAR-M transformation therapy for solid tumors. In a word, taking macrophages as effector cells transformed by CAR is expected to reverse the tumor inhibitory microenvironment, so as to break through the obstacles of immune cell therapy in solid tumors. 

08  CTL (cytotoxic T lymphocyte) therapy

What cell therapy can be used as an adjuvant therapy for the majority of patients with inoperable advanced cancer? In recent years, researchers have been developing new immunotherapy schemes for these patients, including CTL(cytotoxic T lymphocytes) technology. This technology mainly uses protein, which is unique to cancer cells and has no or low content in normal cells, as bait to select the truly anticancer lymphocytes in peripheral blood, and then further improve and amplify them in vitro, and then return them to patients. MTCA-CTL immunotherapy is a new generation of biological immunotherapy model introduced in China. While ensuring the expansion of non-MHC-restricted killer NK-T cells, directional expansion of HC-restricted CD8++specific CTL cells can make its proportion in cell products reach 60% ~ 70%. The combined effect of this killer cell makes the efficiency of killing tumor cells higher.  

10991650935359999

At present, the multi-target compound antigen peptide biological immunotherapy technology, which is undergoing the second phase of clinical trials in the Cancer Hospital of China Academy of Medical Sciences, is the fifth and brand-new generation of cellular immunotherapy technology, which can optimize the activation method of DC (dendritic cells) to enhance the killing effect of immune cells on tumor cells. At present, it has achieved good clinical results and I believe it will really benefit cancer patients.

Mainly suitable for solid tumors.Head and neck tumor, esophageal cancer, lung cancer, gastric cancer, breast cancer, liver cancer, membranous adenocarcinoma, colorectal cancer, ovarian cancer, uterine cancer, coma cancer, prostate cancer, malignant melanoma, sarcoma and partial malignant lymphoma.

If economic conditions permit and you want to consult MTCA-CTL therapy, you can contact.Cancer-free Home Medical Department (400-626-9916), a detailed assessment of the condition.

09  CAR-NKT therapy

  Natural killer T cells (NKT) are a group of special T cell subsets that express both T cell receptors (TCR) and NK cell receptors on the cell surface, and can produce a large number of cytokines. Such as IL-4 and INFγ. These cells can not only directly dissolve and kill tumor cells, but also play an anti-tumor role through indirect ways (secreted cytokines, activated immune cells, etc.). Recently, a phase I clinical trial jointly conducted by Baylor Medical College in Houston and Texas Children’s Hospital is evaluating a new treatment for children with recurrent neuroblastoma –CAR-NKT cell therapy is expected to break through this bottleneck. Phase I trial, code-named GINAKIT2, used CAR-NKT cells for the first time to treat recurrent neuroblastoma. Eleven children (1~21 years old, with an average age of 7 years old) were all recurrent/refractory high-risk neuroblastoma, with extensive metastasis and no better treatment plan in clinic. The results are very encouraging: Of the 11 advanced patients, The condition of 4 patients was stable, 2 patients achieved partial remission (tumor was obviously reduced), and one of them had complete remission (CR) after receiving the second CAR-NKT cell infusion. In safety, CAR-NKT is safer than CAR-T therapy. No dose-limiting toxicity was observed in the first 28 days after infusion. 

10  Compound immune cell therapy

This technology will alsoSix kinds of cells, such as γδT cells, NK cells, NKT cells, killer T cells, dendritic cells and helper T cells.Activate, multiply 10 million to 20 million cells to 2 billion to 5 billion cells, and then inject them into patients. Cultivating such important immune cells at the same time greatly improves the therapeutic effect compared with single treatment.

Except for some leukemia and malignant lymphoma,It can be used for the treatment of most cancers, and has a good effect in refractory cancer types and advanced cancers. Besides,Compound immune cells also play a great role in improving immunity and strengthening the body.

Xiaobian has something to say

In recent years, due to the development of medical level, new cancer treatment methods have appeared one after another, among which cellular immunotherapy is in full swing, which brings new hope to cancer patients. According to the latest statistics, compared with patients with advanced lung cancer, gastric cancer and liver cancer who only receive surgery, radiotherapy and chemotherapy, adjuvant cellular immunotherapy can prolong the survival time of patients and significantly improve the data effect. In fact, tumor treatment is actually a complex "project", and it is difficult to achieve good results by relying solely on a certain treatment method. Tumor treatment needs the cooperation of various treatment methods to achieve the final victory in the fight against cancer. 

通过admin

For non-emergency medical treatment, please give priority to Internet hospitals.

At the press conference on epidemic prevention and control in Guangzhou on December 6, Zhang Yi, deputy director and spokesperson of Guangzhou Municipal Health and Wellness Committee, reminded the general public that if there is a non-emergency medical need in the near future, please give priority to Internet hospitals or go to primary health care institutions nearby.

According to Zhang Yi, since October 20th, Internet hospitals in Guangzhou have made 270,700 online consultations and issued 15,300 electronic prescriptions, and therapeutic drugs have been quickly delivered to patients by express delivery.

"We have asked medical institutions with Internet hospitals to give full play to the advantages of remote consultation and non-contact medical treatment in Internet hospitals." Zhang Wei said that medical institutions with Internet hospitals will continue to enrich the online diagnosis and treatment power, actively carry out online consultation and improve the drug distribution mechanism; Continuously optimize the online consultation process of fever clinics, respiratory departments, pediatrics, obstetrics and other departments, continuously improve the online consultation experience, ensure sufficient online number sources, standardize online consultation for medical staff, and provide accessible, fast, convenient and safe online consultation, triage and health science services to the public to the maximum extent.

It is reported that at present, all the top three hospitals in Guangzhou have opened Internet hospitals. Almost all hospitals can find Internet hospitals through WeChat WeChat official account, applets, etc. After finding them, they can directly enter the Internet Hospital page of the hospital to register.

Through Internet hospitals, patients can consult online and make follow-up visits without leaving home. Some Internet hospitals can also provide online prescription and express delivery service for patients with chronic diseases.

At present, the epidemic prevention and health guidelines published by several districts sort out the information of Internet hospitals in relevant jurisdictions as follows. Neighborhoods in need can find Internet hospitals in their own jurisdictions as needed and seek online health consultation services.

Haizhu district internet hospital

Wechat applet can log in by searching for the following name:

1. Dr. Ding Bai (Guangdong Second People’s Hospital)

2. zhujiang hospital Internet Hospital of Southern Medical University

3. Guangzhou Red Cross Hospital Internet Hospital

4. Internet Hospital of the Second Hospital of Guangzhou Medical University (the Second Affiliated Hospital of Guangzhou Medical University)

5. Internet Hospital of Integrated Traditional Chinese and Western Medicine Hospital of Southern Medical University

6. Yixian Wisdom Service (Sun Yixian Memorial Hospital of Sun Yat-sen University)

Tianhe district internet hospital

Wechat applet can log in by searching for the following name:

1. Internet Hospital of the Third Affiliated Hospital of Southern Medical University

2. Internet Hospital of the Sixth Affiliated Hospital of Sun Yat-sen University

3. Internet Hospital of the Third Affiliated Hospital of Sun Yat-sen University

4. Internet Hospital of the First Affiliated Hospital of Jinan University

5. Internet Hospital of Zhongshan Eye Center, Sun Yat-sen University

6. Internet Hospital of Guangzhou Twelfth People’s Hospital

7. Internet Hospital of Stomatological Hospital affiliated to Guanghua School of Stomatology, Sun Yat-sen University

8. Guangzhou Women and Children Medical Center Internet Hospital

Baiyun district internet hospital

Wechat applet can log in by searching for the following name:

1. Baiyun District Public Health Internet Consultation Platform

2. The First Affiliated Hospital of Guangzhou University of Chinese Medicine

3. Southern Hospital

Panyu district internet hospital

Wechat applet can log in by searching for the following name:

1. Guangzhou Panyu District Central Hospital Internet Hospital

2. Internet Hospital of He Xian Memorial Hospital, Panyu District, Guangzhou

Huadu district internet hospital

Wechat applet can log in by searching for the following name:

1. Guangzhou Huadu District People’s Hospital Internet Hospital

2. Guangzhou Hospital of Integrated Traditional Chinese and Western Medicine

Huangpu district internet hospital

Wechat searches for the following WeChat official account to log in:

1. "Jianke Doctor" WeChat official account (Qishi Hospital)

2. "Zhongai Medical Companion" WeChat official account (Zhongai Hospital)

3. "Guangzhou Asia-Pacific International Health Examination" WeChat official account (Asia-Pacific Comprehensive Clinic)

Guidelines for internet hospitals in some hospitals

Guidelines for Internet Hospitals of Guangdong Second People’s Hospital

There are more than 600 doctors in the Second People’s Hospital of Guangdong Province who can make online home visits in Internet hospitals, covering 64 departments and AI doctor services. Residents do not need to run to the hospital, they can consult the doctors in the Internet Hospital of the Second Provincial Medical University with one click. After prescribing, they can also choose to circulate the prescription and take medicine outside the hospital.

Entrance 1: "Guangzhou Haizhu Publishing" WeChat WeChat official account

The online consultation platform of "Dr. Ding Bai", the first regional medical and health communication cloud platform in Guangdong, which was jointly established by the Propaganda Department of Guangzhou Haizhu District Committee of the Communist Party of China, Haizhu District Health and Health Bureau and Guangdong Second People’s Hospital, has been officially launched, and has been launched on the WeChat WeChat official account of "Guangzhou Haizhu Publishing".

Use steps:

Step 1: Click to follow "Guangzhou Haizhu Publishing" WeChat WeChat official account;

Step 2: Click "Send Message" to enter the dialogue page;

Step 3: After entering the dialogue page, click "Neighborhood Necessary" → "AI Consultation" to enter the platform, and then click the "Famous Doctors Online" module on the "AI Consultation" page to directly link to "Dr. Ding Bai" in the Internet Hospital of the Second Provincial Medical University.

Entrance 2: Guangdong Second People’s Hospital WeChat WeChat official account

Scan the code to pay attention to the WeChat WeChat official account of the Second People’s Hospital of Guangdong Province. When you enter WeChat official account, click the menu bar, and click Hospital Services-Online Consultation-Online Consultation-Select Doctors. You can find the same clinical specialists as offline, and provide medical services such as consultation, consultation and report interpretation. Doctors write prescriptions online, and drugs can be delivered directly to the door through the prescription circulation platform.

Reminder: Guangzhou medical insurance patients with special needs can make a follow-up visit online at Dr. Ding Bai.

Guangzhou first-class special medical insurance patients can directly make online follow-up visits and make medical insurance settlement.

A class of outpatient patients who have prescribed prescriptions in the offline clinic of the Second Provincial Hospital can find an online doctor to make a follow-up prescription through the "Follow-up Prescription" module in the "Doctor Ding Bai" APP. With your fingers, you can realize the settlement of chronic medical insurance and the delivery of drugs to your home without leaving home, making the operation easier.

In addition to continuing to provide online consultation and home delivery services for patients with chronic diseases and common diseases, the Internet Hospital of the Second Provincial Medical University can also provide related services in COVID-19, such as nucleic acid detection appointment, nucleic acid report inquiry, COVID-19 AI screening, COVID-19 sign reporting, COVID-19 encyclopedia knowledge and COVID-19 policy free consultation, as well as nutrition, psychology, nursing, medication and other specialist consultations and health science education.

Guidelines for Internet Hospitals in zhujiang hospital

In order to further protect the medical needs of patients and reduce the gathering of people, citizens and friends can make one-click operation through zhujiang hospital Internet Hospital and consult experts online.

There are more than 50 visiting specialties in zhujiang hospital Internet Hospital of Southern Medical University, and nearly 400 in-hospital experts make on-line visits, providing services including chronic disease follow-up, specialist outpatient service, specialist nursing, medication consultation, self-help drug purchase in the hospital, and providing services such as Internet diagnosis and treatment, pharmacy service, follow-up management, rehabilitation tracking and health education.

Applicable patients: patients with chronic diseases and common diseases.

Scope of application of medical insurance: patients who have successfully handled the first-class medical insurance in Guangzhou and are in the period of validity.

Applicable diseases of medical insurance: 26 kinds

major function

1. Online follow-up, prescription renewal: zhujiang hospital Internet Hospital applet provides online specialist consultation, follow-up and prescription renewal for chronic diseases and common diseases, and delivers medicines to home without leaving home.

2. Specialized nursing clinic: specialized nursing consultation such as respiratory and critical care medicine, cardiovascular medicine, stroke rehabilitation, peritoneal dialysis, etc.

3. Medication consultation: Professional pharmacists provide comprehensive medication guidance to prevent wrong medication.

4. Nutrition consultation: carry out nutritional intervention and diagnosis and treatment of chronic diseases (diabetes, hypertension, gout, nephropathy, tumor, etc.); Nutrition and weight management during pregnancy; Nutrition consultation for special groups (children, the elderly, pregnant women).

5. Interpretation of physical examination report: Physicians in health management department interpret the physical examination report online to guide in-depth diagnosis and treatment.

6. Carry out health education

7. Self-help drug purchase: Some preparations independently developed by zhujiang hospital can apply for self-help prescription renewal.

Registration telephone number: 4008933900

Consultation time: Monday to Friday from 8: 30 to 12: 00; 13:00-17:00

Guidelines for Internet Hospital of Zhongshan First Hospital

At present, 200+ cloud departments have settled in the Internet Hospital of the First Hospital of Zhongshan, and 1,700+medical staff have made online visits. At the moment of the epidemic, the function of Internet hospital [online expert consultation] allows the majority of patients to stay at home and see a doctor at home.

Citizens and friends use the function of [online inspection appointment] in the Internet hospital, doctors issue inspection items online, patients complete payment online, and make an appointment to go to the hospital for inspection at an appropriate time; After the examination, the patient can check the report results on the mobile phone without going back and forth to the hospital to get the report.

Through the [internet plus Nursing] function, patients with mobility difficulties can receive professional medical care services at home, and the on-site nurses follow the standard service process and have a strict nursing quality and safety supervision and training system.

The function of Internet Hospital of Zhongshan No.1 Hospital [Follow-up for Chronic Diseases] makes the patients who return to the hospital no longer have to go to the hospital, queue up for a long time, and find a doctor. Just select the past prescription in the last three months on the mobile phone, and the medicine can be renewed with a click, and the medicine will be delivered to the door by courier.

In addition, the Internet Hospital of the First Hospital of Sun Yat-sen relies on multi-disciplinary professionals to gather the wisdom of experts in various disciplines and form an all-round and professional diagnosis and treatment model. The patient can make an appointment online through mobile phone. After the doctor accepts and understands the condition, he can organize multidisciplinary experts to discuss the case and provide patients with a personalized and efficient diagnosis and treatment plan.

The Internet Hospital of the First Hospital of Zhongshan can also provide free consultation service for patients with fever and patients who have questions about COVID-19. Just fill in the questionnaire, personal symptoms, medical history and other information, and upload relevant examination pictures, and you can make an appointment with experts for consultation for free. And through the function of COVID-19 nucleic acid billing, citizens can make their own billing with one-click appointment and go to the hospital for COVID-19 nucleic acid testing.

Guidelines for Internet Hospital of Guangzhou First People’s Hospital

1. Pay attention to the WeChat service number and choose the expert consultation service.

① Pay attention to the WeChat service number of [Guangzhou First People’s Hospital], click Outpatient, enter the [Internet Hospital] applet, and select [Online Outpatient] or [Medical Insurance Outpatient];

Directly scan the sunflower code of the Internet Hospital of Guangzhou First People’s Hospital, enter the applet, and select [Online Clinic] or [Medical Insurance Clinic];

(2) select departments and doctors, enter the doctor’s home page, click on the "expert consultation"-"consultation now".

2. Read and check the Informed Consent, add the patient, fill in and upload the disease-related information.

① Add patients, up to 5 people; (2) Choose the purpose of consultation, fill in the description of the illness, and upload relevant information about the patient’s treatment. ③ Pay the consultation fee and wait for the doctor’s reply.

3. The doctor communicates with the patient online (the order is valid within 48 hours after submission, and the doctor will receive the consultation as soon as possible. )

4. Doctors prescribe drugs, patients pay orders and fill in the address accurately, and drugs are delivered home by logistics.

Tips:

1. For the sake of medical safety, the current online diagnosis and treatment of "Internet Hospital" is limited to patients with common diseases and chronic diseases, and it is not suitable for patients who are newly diagnosed, acute, dangerous, severe, chronic diseases, colds and fever. Children patients need to be accompanied by their guardians to complete the appointment.

2. When your condition changes or there are other conditions that are not suitable for online diagnosis and treatment, it is recommended that you go to the nearest medical institution in time to avoid delaying your condition.

3. The doctor will receive the consultation within 48 hours, and the overtime system will automatically refund the fee. Warm reminder: experts use off-hours to provide online diagnosis and treatment services for patients. Please wait patiently for the expert’s reply and thank you for your cooperation.

4. If you are eligible for the medical insurance for employees in Guangzhou and the insured persons with specific diseases in the first-class outpatient clinics of urban and rural residents in Guangzhou, please choose the medical insurance clinic and tell the doctor to prescribe medical insurance, and you can use WeChat medical insurance to settle the order.

5. After the prescription is issued, the patient needs to complete the payment within 72 hours, and the overtime prescription will automatically become invalid.

6. At present, the method of taking medicine only supports logistics distribution, and the courier fee is paid. Once the medicine is delivered from the warehouse, if there is no quality problem with the medicine, it will not be returned. Please do a good job in drug acceptance when receiving the courier. At present, the distribution scope of drugs in Internet hospitals in our hospital covers the epidemic control area. If there is any problem in the distribution of drugs in relevant areas, we will communicate with patients in advance, and the distribution time of drugs affected by the epidemic will be delayed. Please understand.

7. Hospitals can provide invoices for online consultation fees and drug fees. If invoices need to be printed, they can be downloaded and printed at the "Electronic Invoice" on the homepage of the "Internet Hospital" applet.

8. The Internet Hospital of the First Hospital of the City will carry out free online free clinic activities from time to time, and experts from different disciplines will sit in the "cloud" to provide free online consultation services for everyone.

Guidelines for Internet Hospitals in the Second Hospital of Guangzhou Medical University

According to the introduction of the Second Affiliated Hospital of Guangzhou Medical University, there are more than 500 medical staff who take turns to go online to the Internet Hospital, providing online consultation, cloud consultation, medical insurance for chronic diseases, nursing consultation, etc. In addition to serving general health consultants, online services are also provided for patients with chronic diseases who need follow-up visits, patients whose condition is stable after surgery, and people who need to know about nursing and rehabilitation methods when they encounter physical discomfort or illness changes during their stay at home.

Citizens and friends can pay attention to WeChat official account, the Second Affiliated Hospital of Guangzhou Medical University, and choose the menu "Patient Service-Internet Hospital" to enter the Internet hospital, or search for the applet "Patients in the Internet Hospital of the Second Affiliated Hospital of Guangzhou Medical University" or scan the QR code of the Internet hospital applet to enter directly.

On-line consultation improves the consultation efficiency.

Online consultation, some patients will politely say hello to the doctor and ask if the doctor is in. The doctor didn’t answer for a while, and when the doctor is free, he will reply "Hello, yes, what can I do for you?" The patient may have left the internet clinic again. Once and for all, the whole consultation time will last for a long time.

How to improve the consulting efficiency? Experts from the Internet Hospital of the Second Hospital of Guangzhou Medical University gave advice. When asking questions, describe the condition as clearly as possible, and explain clearly the beginning and duration of symptoms. If you have relevant pictures or inspection reports, you can also send them to the consulting doctor.

Drug distribution zhiduo d

Prescriptions issued before 5: 00 on working days will be sent by SF Express before work on the same day. See SF Express Delivery System for the specific receiving time. Prescriptions written after 5 o’clock will be sent before work on the next working day.

Please confirm the mailing address before the patient replenishes the prescription, so as to avoid delaying medication due to distribution reasons. Patients in the middle and high risk control area can ask the resident volunteers to pick them up at the No.1 special window of the Western Pharmacy of the Second Hospital of Guangzhou Medical University.

Text finishing/Guangzhou Daily Xinhua City Reporter: Weng Shuxian

通过admin

Son of the Weather really surpasses Your Name. "Is it?


Special feature of 1905 film networkThe goal of production is to hope to surpass the previous work.

Three years ago, Your Name. "made Makoto Shinkai famous, from a niche animation director to the mass market. The film won 25 billion box office in Japan that year, and the global box office also reached a record of 330 million US dollars, surpassing becoming the world’s highest-grossing Japanese film.


Three years later, Makoto Shinkai, wishing to break through himself, brought a new work, The Son of the Weather, which was still favored by Japanese audiences. Up to now, Japan’s box office has exceeded 14 billion yen, and it will also represent Japan in the best international film Oscar next year.

However, The Son of the Weather really surpassed Your Name. "Is it?

First of all, from the box office, although it is currently the top box office champion in Japan, this figure is far less than your name. 》。 China mainland opened more than 45 million yuan on its first day of release. Without considering the influence of competitors, there is still some gap compared with the previous box office of more than 76 million yuan in the same period.

Look at the audience’s evaluation, "Your name. "On Douban, it has a high score of 8.4, and" The Son of the Weather "has a score of 7.1, which is also a lot behind.

Whether it’s the China fans who began to pursue Makoto Shinkai animation from "Five centimeters per second" or based on the analysis of the audience portraits of these two animated films in mainland China, the core audience of Makoto Shinkai animation has always been teenagers under 30.

For "The Son of the Weather", most people still praise the film for its Makoto Shinkai-style classic painting style and beautiful music, but there are many critical voices at the story level:"The plot is really fascinating and fascinating", "The whole story is like a conventional light novel", "Too many logical injuries, rambling plots and forced happy endings."


Makoto Shinkai still tells the story of love between boys and girls. Has the taste of the audience changed now, or has Makoto Shinkai changed? In his forties, he is in the heyday of his creative life and is tasting Your Name. After the commercial sweetness brought by "",did he start to fall into the bottleneck?

"Your name. "Mode 2.0?

The creative idea of "The Son of the Weather" came from a moment when Makoto Shinkai looked up at the sky: "It would be great if I could fly to the cumulonimbus clouds and relax for a while", and it was this idea that prompted him to create this animation about the sky.

The production cycle of the film is one year, and the behind-the-scenes team is mainly "Your Name". ",including producer Genki Kawamura, role designer Tanaka Masayoshi and the score RADWIMPS band.

The painting supervisor was replaced by Tudu Tamura, who was born in Ghibli, and the art supervisor was replaced by Hiroshi, who worked with Makoto Shinkai — — Like The Son of the Weather, the scenes are full of rain.

The court of words and leaves, which has been raining.

There are more than 1700 shots in the whole film, which is better than Your Name. There are more than 100, and each frame has been confirmed by the production team. If you only look at posters or stills, you will probably have an illusion: this is another "Your Name". 》?

Yes, it’s still Makoto Shinkai’s exquisite and beautiful painting style. The combination of real-life photos with later drawing, emphasizing bright colors, using light and shadow contrast, etc. This kind of extreme rendering and beautification of real scenes and showing the beauty of things in ordinary life is the symbolic style of Makoto Shinkai’s animation.

The upgrade of "The Son of Weather" on the screen is to increase the complexity and realism of the scene. Makoto Shinkai specially invited meteorologists to provide professional suggestions for the presentation of cumulonimbus clouds and rain. In addition, Makoto Shinkai also used two solar light sources on the screen design at the same time, trying to create more beautiful light and shadow effects.

This story can be seen as "Your name. "Sister", the background setting is also based on ancient legends. The previous work is about the fate connection between the red rope and dusk. This time, it shows the special character "Sunny Girl" who has been passed down for thousands of years and can control the weather changes.

Fan Gao, a 16-year-old boy who left home from the island to work hard in Tokyo, came across Yangcai, a girl who lived tenaciously with her younger brother in Tokyo. After learning that Yangcai is a "100% sunny girl" who can dispel the rain, they started to do business to help people who need short sunny days.

When the heavy rain continued, Yang Cai decided to give his life to completely change the weather. At this time, Fan Gao made his choice between love and the fate of the world.

The scenes in the film, such as Tokyo City, Shinjuku Station, and the shrine, can be found in Your Name. Find the corresponding in ". Makoto Shinkai also seems to want to form his own "movie universe", planting many eggs: Tachibana Taki and his grandmother appeared, and the clerk who gave him advice when Fan Gao bought a ring was Miyamizu Mitsuha.

"Your name. The great success of the novel is largely due to the use of two theme concepts, namely "time-space transformation" and "body exchange", which have always been popular with the audience.


The former provides games with narrative structure, such as a large number of sci-fi suspense movies, which provides the audience with a space for fascination and continuous puzzle solving, while the latter brings wonders, and so on are classic examples.

"The Son of the Weather" has the fantasy setting that the whole city is shrouded in rain, which seems to be magnificent. Unfortunately, it only stays in the visual beauty. The legend of "Sunny Girl" or the point that Tokyo was originally a sea 200 years ago is not further developed. Finally, it falls on a middle school love, and the pattern is very small.

Makoto Shinkai’s MV lyric rhythm, accompanied by the monologue or narration of the hero/heroine, can also make up for his lack of narrative ability in animated short films, but Son of the Weather exposed his shortcoming.

He tried to follow the typological template of three-act drama in his plays, which was rather blunt, and the film characters also set up quite routine opposites. The love process between Fangao and Yangcai lacked detailed support and was difficult to be convincing. Yang cuisine appeared in front of the public as a "sunny girl", but it did not attract the attention of the state and government agencies at all; The policeman was portrayed as a villain. After being arrested, Fan Gao was able to escape easily with a pistol. His "Japanese drama run" on the railway track was completely divorced from reality. What’s more, Yang Cai is willing to give her life on her own initiative, without giving her any emotional motives. …

These plot development and logic problems that can’t stand the fine products indirectly hinder our emotional empathy for the hero and heroine, and it is difficult to resonate.

"Your name. Is Makoto Shinkai an unexpected success in animated feature films? This time, he seems to have changed back to the animation director who is not very good at telling stories.

Makoto Shinkai’s Invariance and Change

From "The Son of the Weather", whether at the age of 20 or 40, Makoto Shinkai maintained a valuable sense of youth in his creation, and unswervingly created innocence and romance in the film.

"I need you more than the clear sky!" The love shown in The Son of the Weather is not only the phrase "Even if the whole city is turned upside down by the heavy rain" written in The Little Love Song, but also like the Qiong Yao-style oath "Only when the mountains have no edges and the heavens and the earth are in harmony will you dare to die with you".

Behind the unforgettable love is the eternal theme of Makoto Shinkai’s animation: distance and secret. In the secret of two people based on distance, hit their persistence and pain in love directly.

Alien lovers separated by the universe; Japan, which is divided into two parts in Beyond the Cloud, the Agreed Place; The reality and the country of death in the children chasing the stars; The love between teachers and students in the court of words and leaves; "Your name. Space-time separation in "; Life and death in "The Son of the Weather" and the sail height and sunny vegetables separated at both ends by the sky. …

Based on the differences in time and space, urban and rural areas, age and gender, the love that the hero and heroine carefully guard together or the feat of silently saving the fate of the world is moving based on distance.

Makoto Shinkai’s animation is often evaluated as a "healing system". What we can see from "The Son of the Weather" is the continuation and change of Makoto Shinkai’s creation of the "world system".

What is the "World Department"?

According to the definition of Hiroki Azuma, a Japanese expert in secondary research, "world department" is "a small relationship problem centered on the protagonist (I) and the heroine (you), with no specific settings in the middle, and works directly related to abstract big problems such as the crisis of the world and the demise of the world."

Simply put, it focuses on the pure love between teenagers and girls, but their fate is directly related to the world crisis or the demise of the world. Character setting is often a fatalistic battle girl (you) and an incompetent teenager (me). Teenagers need to make a choice between each other and the world. In the end, most of them sacrifice the ego and achieve the big ego.

EVA is the key work of "World Department", including Makoto Shinkai’s previous cartoons "The Voice of the Star" and "Your Name". "also belong to the" world department ".

The sail height and Yang cuisine in The Son of the Weather are completely in line with the distribution of people in the "world department", and the long rainy days clearly point to "the crisis of the world and the demise of the world".

The definition of "no specific settings in the middle" actually refers to "de-socialization", that is, ignoring the practices of the external environment such as the state and society on the world crisis, and concentrating a huge world problem on the emotional problems of the male and female protagonists.

However, in Son of the Weather, the involvement of "socialization" has obviously increased. Fan Gao’s illegal gun holding, resisting arrest, assaulting a police officer and other acts have strengthened the conflict of opposites and made his love with Yang Cai less pure.

Compare your name. ",Makoto Shinkai’s handling of the ending of the" world system "has also changed.

In the previous work, Tachibana Taki went back to the past to save the town, and then returned to the present to meet with Gong Shui in the street. Even if there is suspense, it will always be a happy ending. This time, the sail is high and Yang Cai is not allowed to give his life. Although they are reunited, Tokyo has always fallen into the disaster of heavy rain, and the ending has not achieved the best of both worlds.

From, The Court of Words and Leaves, Your Name. From "The Son of the Weather" to "The Son of the Weather", Makoto Shinkai’s recent animation works refer to and discuss the social situation, climate change, poverty of young people working illegally and other practical aspects. Makoto Shinkai’s growing pessimism about the current development of the world has also affected his creative style.

After Makoto Shinkai became famous, he was highly anticipated by the animation industry, calling him "the new Miyazaki Hayao". In terms of personal style and audience, he is indeed the most promising animation director after Miyazaki Hayao.

Although he is always addicted to the little love between men and women, Son of the Weather also shows us that he has paid more attention to and thought about the outside world. It’s just that the playwright’s ability is too weak, the handling of realistic issues and love is unbalanced, and his ideological level is far less than that of his predecessor Miyazaki Hayao.

And after the restoration of Spirited Away, it can still be sought after in mainland China, creating a box office success. Will "Children of the Weather" become a classic decades later? It’s hard to conclude that Makoto Shinkai is stuck in the bottleneck, but next, he has to work harder.


通过admin

Global News | The three major US stock indexes collectively closed down. Tesla’s revenue exceeded expectations, and its operating profit declined.

[US stock index]

On Tuesday, July 23rd, EDT, the three major US stock indexes collectively closed down, with the S&P 500 index falling 0.16% to 5555.74 points. Dow Jones index fell 0.14% to 40358.09 points; The Nasdaq index fell 0.06% to 17,997.35.

American debt

On July 23, the benchmark 10-year US bond yield was 4.25%, and the 2-year US bond yield, which is most sensitive to the Fed’s policy interest rate, was 4.40%.

[Hot American stocks]

Among popular US stocks, Apple rose 0.47%, Microsoft 0.43%, NVIDIA 0.77%, Google C 0.14%, Google A 0.07%, Amazon 2.12%, Meta 0.27%, TSMC 0.31%, Tesla 2.04%, AMD 1.20% and Intel 1.26.

[global index]

index Ups and downs PT France CAC40 -0.31% 7598.63 FTSE 100 -0.38% 8167.37 Germany DAX 0.82% 18557.70 Russian RTS 0.67% 1092.67

[China index]

On July 23rd, overnight Hang Seng Technology Index futures fell by 1.88%, Nasdaq China Jinlong Index fell by 1.84%, and FTSE China A50 Index fell by 1.55%.

[China Stock Exchange]

In terms of popular Chinese stocks, Tencent Holdings (Hong Kong stocks) fell by 1.88%, Pinduoduo by 0.86%, Alibaba by 0.72%, Netease by 0.14%, Baidu by 2.06%, Ctrip by 2.20%, LI by 3.47%, Weilai by 4.37% and Xpeng Motors by 6.72%.

[foreign exchange commodities]

foreign exchange exchange rate Up and down (basis point) USD/RMB (RMB) 7.29 +1.5 bp Dollar/Euro 0.92 +2.8 bp USD/JPY 155.64 +450 bp

Commodity futures Ups and downs Latest price COMEX silver 1.04% 29.25 USD/oz COMEX gold 0.35% 2410.60 USD/oz west texas intermediate -2.36% $78.24/barrel Brent crude oil -0.36% $82.26/barrel LME copper -0.97% 9090.68 USD/ton

[Global News]

Musk: It is expected that FSD will be approved in China before the end of the year.

Elon musk, CEO of Tesla, said in the earnings conference call that he would apply for regulatory approval in Europe and China to implement the supervised FSD, and it is expected to be approved before the end of this year. (CBN)

Musk: The construction of Tesla’s super factory in Mexico is currently in a "suspended state"

Musk said that the super factory in Mexico is currently in a suspension stage. But the company will see the situation clearly after the November election in the United States. Everything depends on the political situation. Tesla will wait until the November election before deciding on Mexico’s investment.

Musk: postpone the Robotaxi conference from August to October.

Elon musk, CEO of Tesla, said that the Robotaxi conference would be postponed from August to October. Tesla will deliver cheap models in the first half of next year; It is expected that the production of Roadster sports cars will start next year. The demand for NVIDIA is so high that it is difficult for Tesla to obtain the required GPUs. We need to make more efforts in Dojo to ensure that we have the required (large model) training ability. Tesla will "double the bet" Dojo. We really need to make Dojo work.

Google will invest another $5 billion in its self-driving car business.

Porat, chief financial officer of Alphabet, said that Alphabet plans to make a multi-year $5 billion investment in Waymo’s driverless car division.

Tesla did not give a timetable for the launch of Robotaxi in the financial report.

Tesla announced its second-quarter financial report today, and the financial report did not give the specific launch time of the self-driving taxi Robotaxi. Tesla said in the financial report: "The deployment time of Robotaxi depends on technological progress and the approval of the regulatory authorities. In view of its huge potential value, we are actively grasping this opportunity. At the same time, we are managing our product portfolio with a long-term orientation, focusing on sales growth, maximizing the use of installed infrastructure, and generating enough cash flow to invest in future growth. " Earlier this month, people familiar with the matter revealed that Tesla postponed the release time of Robotaxi from August this year to October.

Google CEO Pichai: Waymo pays 50,000 trips per week.

Alphabet CEO Pichai said that Waymo paid 50,000 trips per week. More than 1.5 million developers use the big model Gemini tool. AI Overview Improve search satisfaction.

Tesla: The new car plan is still on schedule.

Tesla said that the focus of the whole company is still to reduce costs. The new car plan is still on schedule. Cybertruck production is expected to be profitable by the end of the year.

Google executives: Cloud revenue is boosted by the demand for artificial intelligence (AI)

Google executive Ruth Porat said that search contributed the most to the company’s revenue growth. The growth of the search is particularly prominent in the retail industry. Declined to comment on the company’s abandonment of Wiz acquisition. The company has been exploring the "diversity" of its portfolio by acquiring (other companies). This will be my last conference call with analysts from Google. Cloud revenue is boosted by the demand for artificial intelligence (AI).

Alphabet’s cloud revenue of $10.35 billion in the second fiscal quarter was higher than market expectations.

Alphabet’s revenue in the second fiscal quarter was 84.74 billion US dollars, and analysts expected 84.37 billion US dollars; In the second fiscal quarter, Google Cloud revenue was $10.35 billion, and analysts expected $10.09 billion; In the second fiscal quarter, Google’s advertising revenue was 64.62 billion US dollars, and analysts expected 64.53 billion US dollars; In the second fiscal quarter, other business revenue was $365 million, and analysts expected $389.6 million; In the second fiscal quarter, the revenue excluding the cost of traffic acquisition was 71.36 billion US dollars; The operating profit in the second fiscal quarter was $27.43 billion, with an estimated $26.37 billion.

Tesla’s revenue in the second quarter exceeded expectations

Tesla’s revenue in the second quarter was $25.50 billion, and analysts expected $24.63 billion; The adjusted earnings per share in the second fiscal quarter was $0.52, and analysts expected $0.60; The operating profit in the second fiscal quarter was $1.61 billion, and analysts expected $1.81 billion; The gross profit margin in the second quarter was 18%, and analysts expected 17.4%; Free cash flow in the second fiscal quarter was $1.34 billion, and analysts expected $1.92 billion; It is still expected that the sales growth rate will be significantly reduced in 2024; It is expected that the output will increase in the third quarter.

通过admin

Opinions of Hunan Provincial People’s Government on Doing a Good Job in Employment and Entrepreneurship at Present and in the Future

  Hunan Provincial People’s Government

  About doing a good job in employment and entrepreneurship at present and in the future

  Implementation opinion

  Xiang Zhengfa [2017] No.31

The people’s governments of cities, counties and cities, the provincial government departments and commissions, and the directly affiliated institutions:

  In order to do a good job in employment and entrepreneurship in our province at present and in the future, according to the spirit of "Opinions of the State Council on Doing a Good Job in Employment and Entrepreneurship in the Present and in the Future" (Guo Fa [2017] No.28), combined with the reality of our province, we hereby put forward the following implementation opinions.

  First, in-depth implementation of the employment priority strategy

  (A) promoting economic growth and expanding employment benign interaction. Combined with the goal of steady growth and employment protection, the economic growth rate and development model are reasonably determined, and the stability and expansion of employment are taken as the lower limit of interval regulation, so as to promote employment through steady growth and promote economic growth through employment and entrepreneurship. Vigorously implement the strategy of "innovation-led, opening up and rising", and highlight the three major grasping points of "three efforts", "four systems" and "five bases" to promote medium and high-speed economic growth and enhance the ability to pull employment. Strengthen the connection between economic policies and employment policies. When formulating economic reform plans and choosing reform paths, we should make overall consideration of economic benefits and employment expansion effects, and insist on the early introduction of reform measures conducive to steady growth and employment protection, and accelerate the landing. When introducing major policies such as finance, taxation, finance, industry, trade and investment, we should comprehensively evaluate the impact on jobs, employment environment and unemployment risk, and promote the linkage between deepening reform, economic growth and employment expansion, and the coordination between structural optimization, mode transformation and employment transformation. (Provincial Development and Reform Commission, Provincial Department of Finance, Provincial Economic and Information Committee, Provincial Department of Commerce, Changsha Central Branch of the People’s Bank of China, Provincial State Taxation Bureau, Provincial Local Taxation Bureau, etc.). The first one is the lead unit, the same below)

  (2) Develop industries with strong employment absorption capacity. Focusing on building a strong manufacturing province, we will accelerate the development of key industries, and strive to build a number of landmark industrial clusters and bases with high visibility and strong employment absorption capacity in the advantageous industrial fields such as rail transit, construction machinery, biomedicine, electronic information and new materials. Vigorously develop modern service industries such as e-commerce, global tourism, and healthy old-age care, support cultural industries with Hunan characteristics, strive to build brands such as Cultural Hunan Army, Splendid Xiaoxiang and Red Tourism, promote standardization and informationization of modern service industries, and create more employment opportunities. Grasp the trend of industrial transfer, guide the resource-processing, labor-intensive and capital-intensive and technology-intensive industries with cost advantages to transfer from the developed eastern regions to our province, and tap the employment potential of the secondary industry. Accelerate the development of modern agriculture, promote the construction of agricultural and forestry industrial chain and value chain, focus on building agricultural and forestry industrial system, production system and management system, promote the overall planning of grain, economy, feed, agriculture, forestry, animal husbandry and fishery, the integration of planting, breeding and processing, and the integration of primary and secondary industries to expand farmers’ employment space. (Provincial Development and Reform Commission, Provincial Science and Technology Department, Provincial Economic and Information Committee, Provincial Civil Affairs Department, Provincial Department of Finance, Provincial Department of Human Resources and Social Security, Provincial Department of Commerce, Provincial Agriculture Committee, Provincial Department of Culture, Provincial Health and Family Planning Commission, Provincial Tourism Commission, etc.)

  (3) Give play to the role of small and medium-sized enterprises as owners’ channels. We will implement a series of support policies such as tax reduction and burden reduction for financing small and micro enterprises, and clean up and standardize the fees and inspections related to enterprises. Guide enterprises to improve employment management, give one-time job subsidies to qualified labor-intensive enterprises and small and medium-sized enterprises, and continuously improve the ability of small and medium-sized enterprises to absorb employment. Efforts will be made to promote the innovation and development of small and medium-sized enterprises, encourage universities, research institutes and enterprises to transfer scientific and technological achievements to small and medium-sized enterprises, and regions with conditions can promote the open sharing of a number of basic patents or purchase a number of technical resources to support the collaborative innovation of small and medium-sized enterprises. Improve the service system of small and medium-sized enterprises, promote the construction of public service demonstration platforms in counties and cities, carry out the identification of provincial-level entrepreneurial innovation bases for small and medium-sized enterprises, and give full play to the radiation service function of public service platforms for small and medium-sized enterprises. We will implement plans such as training leading talents of small and medium-sized enterprises and Galaxy training to develop and expand the ranks of entrepreneurs. (Provincial Economic and Information Committee, Provincial Development and Reform Commission, Provincial Department of Education, Provincial Science and Technology Department, Provincial Department of Finance, Provincial State Taxation Bureau, Provincial Local Taxation Bureau, Provincial Intellectual Property Office, etc.)

  Second, support the development of new employment patterns

  (4) Support the development of emerging formats. Supported by the new generation of information network and artificial intelligence technology, we will promote the innovative development of platform economy, crowdsourcing economy and sharing economy, and activate the new advantages of information network and artificial intelligence innovation and entrepreneurship. Improve the access management of emerging formats and strengthen supervision after the event. Eligible emerging enterprises and employees can enjoy preferential policies to encourage entrepreneurial innovation and development. Encourage government departments at all levels to actively purchase products and services from emerging enterprises according to the actual situation. (Provincial Development and Reform Commission, Provincial Economic and Information Committee, Provincial Department of Finance, Provincial Department of Commerce, Provincial Administration for Industry and Commerce, etc.)

  (five) improve the employment and social security systems that adapt to the characteristics of the new employment pattern. Support workers to achieve diversified employment through emerging formats. If employees sign labor contracts with enterprises in emerging formats, enterprises should participate in employee social insurance according to law, and eligible enterprises can enjoy relevant support policies such as employment and entrepreneurship. Other qualified employees can participate in pension, medical insurance and pay housing provident fund as flexible employees according to relevant regulations, explore ways to protect unemployment and work-related injury insurance for flexible employees, and eligible employees can enjoy flexible employment and self-employment support policies. Accelerate the construction of "online social security" to facilitate the participation and transfer of employees in new employment forms. The establishment of the province’s housing provident fund off-site transfer and connection platform, to provide off-site transfer and connection services for paid employees who are employed across regions. (Provincial Department of Human Resources and Social Security, Provincial Department of Finance, Provincial Department of Housing and Urban-Rural Development, etc.)

  Third, promote innovation and entrepreneurship to promote employment

  (6) Optimize the entrepreneurial environment. Deepen the "streamline administration, delegate power, strengthen regulation and improve services" reform, reduce institutional costs, innovate supervision methods, optimize government services, reduce market access thresholds and institutional transaction costs, and remove institutional and institutional obstacles that restrict workers’ entrepreneurship. Comprehensively clean up all kinds of industry access certificates, production licenses and professional qualification certificates, accelerate the electronic registration of enterprises and the issuance and application of electronic business licenses, and fully implement the "multi-certificate integration, one photo and one yard" of enterprise market entities. According to the principle of "no entry is forbidden", all kinds of entrepreneurs are allowed to enter all industries and fields that are not prohibited by national laws and regulations on an equal footing, and all kinds of innovative and entrepreneurial forms of ownership economy are encouraged to compete for development. Combine the actual market supervision function and law enforcement power, promote the reform of comprehensive administrative law enforcement in the field of market supervision, focus on solving problems such as repeated inspections and multiple law enforcement, and constantly optimize a good environment conducive to workers’ participation in entrepreneurship. (The provincial development and reform commission, the provincial office, the provincial administration for industry and commerce, etc.)

  (7) Strengthen the construction of entrepreneurial carriers. Make overall planning and rational layout, build a number of innovative and entrepreneurial carriers with their own characteristics and high level, and enhance their entrepreneurial service capabilities. Actively strive to build national-level "double innovation" demonstration bases and build a number of provincial-level "double innovation" demonstration bases. Accelerate the development of market-oriented, professional, integrated and networked creative space, and form an open and shared service platform for scientific and technological innovation and entrepreneurship. Pilots will promote the transformation of old commercial facilities, storage facilities, idle buildings and surplus commercial real estate into business incubation bases. Strengthen the construction of incubation bases, give full play to the resource agglomeration and radiation leading role of incubation bases, provide guidance services and policy support for entrepreneurs, and appropriately extend the incubation period for startups that really need it. We will continue to implement the construction of provincial-level demonstration bases for innovation and entrepreneurship to promote employment, further promote the creation of entrepreneurial cities and promote the "2151 Project" for entrepreneurship to promote employment, and actively cultivate an entrepreneurial ecosystem. (Provincial Department of Human Resources and Social Security, Provincial Development and Reform Commission, Provincial Department of Science and Technology, Provincial Department of Finance, Provincial Department of Housing and Urban-Rural Development, etc.)

  (eight) the full implementation of entrepreneurship support policies. We will continue to push forward the "Three-year Action Plan for Innovation and Entrepreneurship", continue to increase the investment in support funds for employment driven by innovation and entrepreneurship, and further optimize the expenditure structure. Except that it can’t be used to expand the guarantee funds for entrepreneurial guarantee loans in cities, counties and cities and supplement discount funds, other project expenditures will continue to be implemented in accordance with the Interim Measures for the Management of Support Funds for Employment Driven by Innovation and Entrepreneurship in Hunan Province (Xiang Cai She [2015] No.35). For qualified start-ups or individual industrial and commercial households registered for the first time, rent subsidies, one-time start-up expenses subsidies and trademark registration subsidies are given according to regulations. Actively implement the preferential tax policies to support the entrepreneurship and employment of key groups. According to the Notice of the Ministry of Finance and the State Administration of Taxation, Ministry of Human Resources and Social Security on Continuing to Implement Tax Policies to Support and Promote Entrepreneurship and Employment of Key Groups (Caishui [2017] No.49), within the scope authorized by the state, key groups will be given tax support policies for employment and entrepreneurship according to the top standard. According to the spirit of Guiding Opinions of the Ministry of Human Resources and Social Security on Supporting and Encouraging the Innovation and Entrepreneurship of Professional and Technical Personnel in Public Institutions (No.4 [2017] of the Ministry of Human Resources and Social Security), professional and technical personnel in public institutions are supported and encouraged to work in enterprises, participate in project cooperation, innovate part-time, start a business on the job or leave their posts to innovate and start a business, and entrepreneurs enjoy corresponding preferential policies according to regulations. (Provincial Department of Finance, Provincial Department of Human Resources and Social Security, Provincial State Taxation Bureau, Provincial Local Taxation Bureau, etc.)

  (9) Focus on broadening financing channels. According to the spirit of the Notice of the Ministry of Human Resources and Social Security of the Ministry of Finance of the People’s Bank of China on Implementing Entrepreneurship Guarantee Loan to Support Entrepreneurship and Employment (Yinfa [2016] No.202), the policy of entrepreneurship guarantee loan will be fully implemented, and the loan target will be extended to students who have returned from studying abroad, employees and unemployed people in enterprises with excess capacity, migrant workers who have returned home to start businesses, online merchants, and poor people who have set up files and set up cards; The maximum amount of personal business guarantee loan is adjusted to 100,000 yuan; For eligible borrowers who start a business in partnership or organize to start a business together, according to the number of people who start a business in partnership or organize to start a business together, the maximum loan amount per person is 100,000 yuan and the maximum loan amount is 500,000 yuan; The maximum term of personal business guarantee loan is adjusted from 2 years to 3 years. In order to encourage financial institutions to lend, the loan interest rate can rise appropriately on the basis of the benchmark loan interest rate announced by the People’s Bank of China. The specific criteria are that the rise in poverty-stricken areas (including 40 key poverty alleviation and development counties in our province and poverty-stricken counties in contiguous poverty-stricken areas nationwide) does not exceed 3 percentage points, and the rise in other areas does not exceed 2 percentage points. Specific handling requirements and procedures shall be implemented in accordance with relevant documents. Promote the establishment and operation of investment funds for emerging industries in Hunan Province, encourage them to set up sub-funds for employment and entrepreneurship, provide equity financing support for college graduates and other groups to start businesses, increase investment in start-ups and broaden financing channels for start-ups. (Changsha Central Branch of the People’s Bank of China, Provincial Development and Reform Commission, Provincial Department of Finance, Provincial Department of Human Resources and Social Security, Hunan Banking Regulatory Bureau, Hunan Securities Regulatory Bureau, etc.)

  Fourth, promote the employment and entrepreneurship of key groups as a whole

  (ten) to encourage college graduates to obtain employment through multiple channels. Implement the employment and entrepreneurship promotion plan for college graduates, improve the service system covering all stages inside and outside the school and the whole process of employment and entrepreneurship, and promote the docking of supply and demand and accurate assistance. Education guides college graduates to establish a correct concept of employment, better participate in employment and entrepreneurship activities, and dare to achieve employment through entrepreneurship. We will implement a flexible academic system, relax students’ study years, allow them to adjust their academic progress, retain their school status, drop out of school, and innovate and start businesses. We will implement the grass-roots growth plan for college graduates, guide and encourage college graduates to find jobs in urban and rural grass-roots units and small and medium-sized enterprises, implement policies such as tuition compensation, student loan compensation, and financial subsidies, and establish a long-term mechanism for college graduates to "get down, stay, do well, and move." Encourage college graduates to work in social organizations. For social organizations that absorb college graduates’ employment, those who meet the conditions can equally enjoy the enterprise employment support policy. Encourage scientific research project units to attract college graduates to participate in research, and include social insurance subsidies into labor expenses according to regulations, and there is no proportional limit on labor expenses. Encourage college students to enlist in the army, and implement policies such as tuition subsidy, student loan compensation, special care and resettlement. Reasonably arrange the recruitment (recruitment) of institutions and institutions and the recruitment time of grassroots service projects for college graduates, optimize the recruitment (employment) process, and provide convenience for college graduates to find jobs. Support college graduates to work as interns in international organizations. Increase the intensity of employment probation,Allowance for employment trainee can be used for trainee units to handle personal accident insurance for trainees and guidance and management expenses for trainees. In hard and remote areas, old industrial bases and national poverty-stricken counties, the scope of trainees can be extended to unemployed secondary vocational graduates who leave school. Vigorously promote the Furong talent plan, open up a fast track for talent recruitment in colleges and universities, and guide outstanding college graduates to stay in Hunan to work. We will increase assistance to college graduates in difficulty, and adjust the scope of one-time job-seeking and entrepreneurship subsidies to graduation year college graduates from low-income families, poor families with disabilities, and poor families with files and cards, orphans, destitute, disabled and graduates who have obtained national student loans. We will continue to implement the "Farmer College Student Training Plan" and grant tuition subsidies according to regulations. Relying on the provincial and municipal entrepreneurship incubation system for the disabled, we will implement measures such as free entrepreneurial venues and entrepreneurial success awards for qualified graduates with disabilities to guide the implementation of entrepreneurial projects for disabled college students. (Provincial Department of Human Resources and Social Security, Provincial Department of Education, Provincial Economic and Information Committee, Provincial Department of Finance, Provincial Department of Civil Affairs, Changsha Central Branch of the People’s Bank of China, Provincial Administration for Industry and Commerce, Provincial Intellectual Property Office, Provincial Federation of Trade Unions, Communist Youth League Committee, Provincial Disabled Persons’ Federation, etc.)

  (eleven) the steady resettlement of employees of enterprises with excess capacity. Adhere to the principle of the enterprise as the main body, follow the law and regulations, make classified policies, make precise efforts, broaden the diversion channels, strengthen the assistance of transferring jobs and re-employment, and do a good job in the resettlement of employees in enterprises with de-capacity. Encourage de-capacity enterprises to resettle employees through multiple channels, support enterprises to do their best to tap the potential of internal resettlement, and lower the threshold of job-holding subsidies and raise the standard of job-holding subsidies for those who do not lay off employees or less. Promote the diversion of workers to find jobs and start businesses, and give enterprises employment support policies in accordance with the regulations if new posts in the unit are absorbed by people who have diverted production capacity; For the triage personnel who start their own businesses, priority should be given to settling in various business incubation bases and implementing business support policies; For people with employment difficulties who are really difficult to resettle, priority should be given to new and retired public welfare posts. It is necessary to include the laid-off workers of qualified enterprises with capacity reduction into the scope of support of the current employment and entrepreneurship policy. We will carry out in-depth "double-assistance" work for employees with difficulties, implement caring actions for employees with difficulties in the steel and coal industries, and help employees with difficulties in working ability achieve stable employment. Actively and steadily handle labor relations in accordance with the law and regulations, and do a good job in the resettlement of employees in the process of slimming and strengthening the body, improving quality and increasing efficiency, and divesting enterprises from social functions. The one-time compensation income legally obtained by the employees who have dissolved the overcapacity of enterprises in the steel and coal industry in this round is in line with the relevant tax laws and regulations, and they can enjoy the personal income tax policy as required.(Provincial Department of Human Resources and Social Security, Provincial Development and Reform Commission, Provincial Economic and Information Committee, Provincial Department of Finance, Provincial State-owned Assets Supervision and Administration Commission, Provincial State Taxation Bureau, Provincial Local Taxation Bureau, Provincial Federation of Trade Unions, etc.)

  (12) Improve the equal employment system for urban and rural workers. Establish and improve the equal employment system for urban and rural workers, guide rural laborers to go out for employment, find jobs locally and actively start businesses. According to the spirit of the Notice of the Ministry of Human Resources and Social Security on Further Improving the Measures for the Administration of Employment and Unemployment Registration (No.97 [2014] of the Ministry of Human Resources and Social Security), rural migrant workers who have lived in cities and towns for more than six months and are unemployed can register unemployment in their permanent residence in cities and towns and enjoy equal public employment services and inclusive employment policies. Promote the orderly employment of rural laborers, and give subsidies for employment and entrepreneurship services to market entities such as human resources service institutions and labor brokers who carry out organized labor export. For workers who live permanently in rural areas and are in a state of landless and unemployed, areas with conditions can explore the registration of unemployment in rural permanent places and provide corresponding employment services and policy support. We will increase the tilt of land use planning indicators for county towns and key towns with good development prospects and more employment, vigorously develop characteristic county economy, charming towns and rural service industries, and create space for rural workers to transfer their employment on the spot. Promote migrant workers to return to their hometowns to start businesses, and include migrant workers’ returning pioneer parks and enterprises founded by migrant workers in the typical selection scope of provincial-level innovation and entrepreneurship-driven employment demonstration. Vigorously develop farmers’ cooperatives, large-scale breeders, family farms, small and micro enterprises in the construction industry and other production and business entities, among which those who register for industry and commerce according to law can enjoy the support policies for small and micro enterprises according to regulations. Vigorously develop rural tourism and actively cultivate rural tourism maker bases.Attach importance to the development of entrepreneurial individual and private tourism economy and cottage industry, and guide all kinds of professionals such as science and technology, art and creative design to participate in rural tourism development and construction across borders. Extend the industrial chain of food, housing, transportation, travel, shopping and entertainment, and support the innovation chain of cultural innovation, tourism innovation and agricultural innovation, protect the ecology, implant culture, cultivate formats, innovate and introduce new formats and new products, and broaden employment channels. (Provincial Department of Human Resources and Social Security, Provincial Development and Reform Commission, Provincial Department of Finance, Provincial Department of Land and Resources, Provincial Agriculture Commission, Provincial Tourism Commission, etc.)

  (thirteen) to do a good job in the employment of other specific groups. Reasonably determine the scope of people with employment difficulties, strengthen the dynamic management and classified assistance in real-name registration system, ensure that at least one person in zero-employment families has a stable employment, keep dynamic zero-clearing, and gradually establish a real-name registration system database to record employment assistance in detail. Strengthen the linkage between social security and employment. When calculating the family income, the necessary employment costs can be deducted for the low-income recipients, and the employment willingness and stability can be enhanced through measures such as "gradually withdrawing the low-income recipients". Make overall plans for the employment of disabled people, minority workers, retired athletes and other groups. Eliminate employment discrimination against specific groups and create a fair employment environment. (Provincial Department of Human Resources and Social Security, Provincial Public Security Department, Provincial Civil Affairs Department, Provincial Department of Finance, Provincial Disabled Persons’ Federation, etc.)

  (fourteen) to promote the employment and entrepreneurship of retired military personnel. Do a good job in the resettlement of demobilized military cadres, vigorously support the employment and entrepreneurship of demobilized military cadres who choose their own jobs, actively carry out employment services, vocational training, business incubation and other services, and implement relevant support policies in accordance with regulations. Intensify the resettlement of retired soldiers, and take rigid measures to ensure the post implementation and proper resettlement for those who meet the working conditions arranged by the government. Fully implement "sunshine resettlement" and broaden the resettlement channels. Based on the performance during the service in the army, the quantitative scoring and post selection are carried out to ensure fairness, justice and openness. For self-employed, it is necessary to strengthen education and training, implement preferential policies, and improve the success rate of employment and entrepreneurship. We will fully implement the "off-site education and training in the province" and encourage retired soldiers to freely choose institutions and majors from the education and training institutions selected by the province through bidding. (Provincial Department of Human Resources and Social Security, Provincial Civil Affairs Department, etc.)

  Five, strengthen education and training and employment and entrepreneurship services

  (fifteen) to improve the quality of education and training. Adhere to the priority of talents, improve the long-term mechanism for improving the quality of workers, accelerate the cultivation of workers with higher skills, better professionalism and professionalism, stronger innovation ability and entrepreneurial spirit, and strive to alleviate the structural contradictions in employment. We will further promote the reform of innovation and entrepreneurship education in colleges and universities, speed up the adjustment and optimization of disciplines and specialties in colleges and universities, improve the early warning and dynamic adjustment mechanism of specialties, and deepen the reform of curriculum system, teaching content and teaching methods. Give full play to the role of vocational education and vocational training, promote the accurate docking of industrial development needs, accurately meet the needs of educated people, accelerate the development of modern vocational education, and strive to improve students’ employability and creativity. Implement the quality improvement plan of modern vocational education, the integration development project of production and education, the revitalization plan of high-skilled talents and the training support plan for craftsmen in big countries. Coordinate the coordinated development of ordinary high schools and secondary vocational education, increase the enrollment ratio of secondary vocational education, and accelerate the development of secondary vocational education and technical education. Carry out vocational training on a large scale, extensively carry out on-the-job training, technical competition, skill competition, mentoring and other activities, accelerate the cultivation of a large number of high-quality workers and technical and skilled personnel with professional skills and craftsman spirit, and ensure that the education funds for enterprise employees are fully extracted and reasonably used. Mobilize the enthusiasm of all parties, and accelerate the implementation of training modes such as integration of work and study, new enterprise apprenticeship system and "internet plus". Improve the diversified evaluation mechanism of skilled personnel, improve the policy of identifying the vocational skill level of skilled personnel and make a good connection with the vocational qualification system.The establishment of vocational qualifications, vocational skill levels and corresponding titles by comparison system, senior workers, technicians and senior technicians employed by the employer can enjoy the same treatment by comparison with the corresponding level of engineering and technical personnel. (Provincial Department of Education, Provincial Development and Reform Commission, Provincial Department of Finance, Provincial Department of Human Resources and Social Security, Provincial Federation of Trade Unions, Communist Youth League Committee, etc.)

  (sixteen) improve the way of vocational training subsidies. Give full play to the positive role of vocational training in promoting employment and serving economic construction. According to the spirit of the Notice of the Ministry of Finance and the Ministry of Human Resources and Social Security on Printing and Distributing the Interim Measures for the Administration of Employment Subsidies (Caishe [2015] No.290), the Catalogue of Vocational Training Subsidies in Hunan Province is formulated and published regularly every two years, and the Catalogue of Jobs (jobs) in Shortage in Hunan Province is published regularly, so as to establish a normal growth mechanism of vocational training subsidies that is compatible with economic and social development and human resources market demand. For the laborers who are engaged in occupations (jobs) and belong to the Catalogue of Jobs (jobs) in Shortage in Hunan Province, the training subsidy standard of that year will be raised by 10% according to the prescribed standards; The subsidy standard for pre-employment skills training of poor laborers has risen by 70% on the basis of similar vocational training subsidy standards. During the training period, 20 yuan will be given a living allowance per person per day according to the actual class time. For industrial enterprises (including agricultural products processing enterprises) that meet the requirements in the parks in poverty-stricken areas, if on-the-job employees are organized to participate in job skills upgrading training and obtain vocational qualification certificates, enterprises will subsidize the poor laborers who have set up files and set up cards according to the pre-employment training subsidy standard by 70%, and other on-the-job employees will be subsidized by enterprises according to 50% of the pre-employment training subsidy standard. Implement training subsidies for urban and rural junior and senior high school graduates enrolled in technical colleges in our province and vocational education graduates from special education colleges. On the basis of the current vocational training subsidy directly subsidizing individuals, according to the characteristics of unemployed people in de-capacity enterprises and poor people who set up files,Take the whole system to purchase training programs and directly subsidize training institutions to carry out centralized training. Innovate entrepreneurship training mode, support qualified universities and social capital to establish entrepreneurship universities, build a multi-level and modular training course system, and include digital training courses, entrepreneurship simulation training and online entrepreneurship training into the scope of government training subsidies. Implement the subsidy policy for skills upgrading of employees participating in unemployment insurance. According to the spirit of the Notice of the Ministry of Human Resources and Social Security and the Ministry of Finance on Issues Related to Unemployment Insurance Supporting Employees to Improve their Vocational Skills (No.40 [2017] of the Ministry of Human Resources and Social Security), employees who have obtained primary (level 5), intermediate (level 4) and advanced (level 3) vocational qualification certificates or vocational skill level certificates since January 1, 2017 will enjoy the employee skills upgrading subsidy as required; If the occupation (type of work) belongs to the Catalogue of Jobs (types of work) in Shortage in Hunan Province, the subsidy standard shall be raised by 10% according to the prescribed standard, and the required funds shall be paid from the unemployment insurance fund. (Provincial Department of Human Resources and Social Security, Provincial Department of Finance, etc.)

  (seventeen) to improve the quality of public employment and entrepreneurship services. Improve the public employment and entrepreneurship service system covering urban and rural areas, and improve the level of equalization, standardization and specialization of services. Efforts will be made to improve the public employment and entrepreneurship service system and strengthen the construction of grassroots employment and social security service platforms in counties, cities, towns (streets) and villages (communities). Promote public employment services to facilitate the people, establish and improve the performance evaluation and incentive mechanism of public employment services, and comprehensively improve the professional level of public employment services. Create a "internet plus" public employment and entrepreneurship service platform, promote the extension of services to mobile terminals and self-service terminals, and gradually realize the sharing of information resources related to innovation and entrepreneurship in the province. In accordance with the general requirements of "integrity, correctness, unity, timeliness and safety", we should accelerate the informationization and precise management of employment and unemployment registration, employment fund audit, employment training, job recruitment and online feedback, and comprehensively improve the quality of public employment and entrepreneurship services in the province. (Provincial Department of Human Resources and Social Security, Provincial Department of Finance, etc.)

  (eighteen) to promote the construction of human resources market. Accelerate the establishment of a unified, open, competitive and orderly human resources market system, break the division between urban and rural areas, regions and industries, and discrimination on identity and gender, improve market operation rules, standardize the recruitment and employment system, and eliminate institutional obstacles affecting equal employment. Enhance the flexibility of the labor market and promote the free flow of labor among regions, industries and enterprises. Simplify the procedures for workers to apply for jobs. In areas where conditions permit, we can establish a mechanism for mutual recognition of physical examination and physical examination results, and try our best to avoid too complicated procedures and repeated physical examinations. Accelerate the informatization construction of human resources market, actively connect with education, industry and commerce, public security and other departments, promote the sharing and utilization of information and data, and create a unified and efficient credit management system. Accelerate the construction process of human resources service standard system, and give play to the leading role of service standards in regulating human resources service behavior. We will improve the legal system of human resources market, respect the dominant position of workers and employers in the market, and protect their legitimate rights and interests according to law. Standardize the implementation of administrative licensing of human resources services according to law, further simplify and optimize the approval process, and improve the convenience and accessibility of services. Strengthen post-event supervision in the human resources market, implement random inspection supervision, establish an annual report publicity system, and explore the use of emerging information technologies to improve supervision efficiency. Strengthen daily supervision and inspection, carry out special actions to clean up and rectify the human resources market order, severely investigate and deal with relevant violations of laws and regulations, and give full play to the supervisory role of various human resources service institutions, industry associations and social forces.(Provincial Department of Human Resources and Social Security, Provincial Development and Reform Commission, Provincial Health Planning Commission, Provincial Administration for Industry and Commerce, Provincial Women’s Federation, Provincial Disabled Persons’ Federation, etc.)

  Sixth, increase the intensity of employment and poverty alleviation

  (nineteen) support the poor areas to develop industries and expand employment. Efforts will be made to promote poverty-stricken areas in the province (referring to poverty-stricken counties in the country, poverty-stricken counties in the province, and poverty-stricken counties will not take off their hats) to enhance their self-development ability, enlarge and strengthen the county economy, and help the poor to find jobs nearby and for a long time. In accordance with the requirements of the Notice of the General Office of Hunan Provincial Committee of the Communist Party of China and the General Office of Hunan Provincial People’s Government on Printing and Distributing Several Policies on Supporting the Development of Industries and Expanding Employment in Poverty-stricken Areas (Xiang Ban Fa [2017] No.29), we will vigorously support the development of industries and promote employment in poverty-stricken areas. For qualified enterprises, a "green channel" will be set up, and a "simplest procedure" will be set up. The "on-the-spot" mode will be implemented in planning permission, land use approval and environmental impact assessment approval, and the "one-stop" handling and "one-time" completion will be implemented for qualified enterprises. We will fully implement various preferential tax policies to support the development of the real economy, the development of small and micro enterprises, scientific and technological innovation, and entrepreneurial employment in poverty-stricken areas. Enterprises that have newly settled in standard factories in parks in poverty-stricken areas will be given rent subsidies according to regulations. Enterprises in poverty-stricken areas will not increase the land price if they increase the land volume ratio in line with the planning and industrial guidance and support development direction without changing the existing industrial land use. Give priority to supporting enterprises in poverty-stricken areas to enjoy preferential policies related to electricity consumption. Support enterprises to go public for financing, and give corresponding rewards according to regulations. We will implement a pilot policy for the transition of pension insurance payment rates. Support enterprises in poor areas to declare the protection of geographical indication products, geographical indication trademarks and Madrid international trademarks, and the provincial finance will give corresponding subsidies according to regulations.(Provincial Poverty Alleviation Office, Provincial Office, Provincial Development and Reform Commission, Provincial Department of Finance, Provincial Economic and Information Committee, Provincial Government Finance Office, Provincial Department of Human Resources and Social Security, Provincial Department of Housing and Urban-Rural Development, Provincial Department of Land and Resources, Provincial Department of Commerce, Provincial Administration for Industry and Commerce, etc.)

  (twenty) improve the implementation of poverty alleviation policies for the employment of poor labor. Efforts will be made to help poor laborers find jobs, intensify labor cooperation to help them get rid of poverty, establish a docking and cooperation mechanism inside and outside the province, actively carry out inter-regional labor cooperation, focus on promoting the docking of poverty-stricken provinces and cities in the east and west, and docking of developed areas and poverty-stricken areas in the province, and improve the degree of organization of labor export. Strengthen the construction of a comprehensive information service platform for poverty alleviation through labor cooperation in the province. Establish a list of tasks, a list of stable posts and a list of responsibilities, clarify the tasks and responsibilities of the exporting and importing places and the provincial government offices abroad, solidly promote the accurate identification, accurate docking, accurate job stability and accurate service of poor laborers, and promote the employment of poor laborers to increase income and stabilize poverty alleviation. Encourage the introduction of the employment of poverty alleviation targets, and give subsidies for employment and entrepreneurship services according to regulations. The employer absorbs the employment of the poor labor force in this province, and gives the employer a one-time post subsidy according to the regulations. Support enterprises to create "employment poverty alleviation workshops" and processing points in towns and villages, and guide poor laborers to find jobs at home. Encourage local governments to integrate training fund resources, and give 1 million yuan to each poor county with good implementation effect according to the spirit of document No.29 [2017] issued by Hunan Office. (Responsible for the Provincial Department of Human Resources and Social Security, the Provincial Department of Finance, the Provincial Poverty Alleviation Office and the offices of the provincial government in Beijing, Shanghai, Hainan, Guangzhou and Shenzhen)

  Seven, strengthen the organization and implementation.

  (twenty-one) to strengthen organizational leadership. All localities should earnestly fulfill the government’s responsibility to promote employment, and the main person in charge of the government is the first person responsible for employment in the region, and the target responsibility system for employment work will be included in the performance appraisal of the leading bodies. It is necessary to strengthen leadership over employment and entrepreneurship, put the promotion of employment and entrepreneurship on an important agenda, improve the coordination mechanism of employment and entrepreneurship led by government leaders, and coordinate and solve key and difficult problems; Reasonably arrange the expenditure of employment funds, strengthen the management and supervision of the use of funds, improve the efficiency of the use of funds, and ensure the completion of various employment goals and the stability of the employment situation. Relevant departments should enhance their overall awareness, cooperate closely and perform their duties. (Provincial Department of Human Resources and Social Security, Provincial Development and Reform Commission, Provincial Department of Finance, etc.)

  (twenty-two) pay close attention to policy implementation. Focus on key policies, innovate propaganda means and methods, carry out refined and accurate propaganda, and strive to realize that employers and workers should know everything about employment and entrepreneurship policies. Incorporate the implementation of employment and entrepreneurship policies into the performance appraisal scope of the province, further refine the targets and tasks, policy implementation, employment and entrepreneurship services, capital investment, mass satisfaction and other indicators, increase the weight, and decompose them layer by layer, and link the performance appraisal results with the allocation of special funds for employment. If the relevant areas fail to perform their duties of promoting employment and cause adverse social impact, the relevant responsible persons and specific responsible persons of the local people’s government shall be held accountable. Improve the incentive mechanism and fault-tolerant and error-correcting mechanism, increase the tilt of policies and funds, and commend them in due course; For those who boldly explore, do their duty, and do not seek personal gain, but make mistakes or mistakes in the process of performing their duties according to laws and regulations due to unforeseen factors, they can be exempted from fault tolerance; Those who fail to perform or perform their duties incorrectly shall be held accountable according to discipline and law. (Provincial Department of Human Resources and Social Security, Provincial Supervision Department, Provincial Department of Finance, etc.)

  (twenty-three) to strengthen statistical monitoring and situation analysis. Improve the employment statistical index system, improve the statistical caliber and survey methods, establish statistical monitoring indicators on new forms and situations of employment and entrepreneurship, and reflect the employment and entrepreneurship situation more comprehensively. Two real-name registration system databases, namely, unemployed college graduates who have left school and workers who have been diverted from production capacity, will be implemented, and the real-name management of registered unemployed people in cities and towns, people with employment difficulties, and poor laborers who have established files will be comprehensively promoted. Do a good job of employment data statistics accurately, strengthen the whole process management of data collection, review, summary and reporting, and ensure the data quality. Strengthen the periodic and periodic scheduling analysis of data such as supply and demand of human resources market, unemployment insurance collection and employment of migrant workers, and keep abreast of the employment situation and trends in the market. Strengthen key monitoring, keep a close eye on major risk points such as large-scale unemployment and labor relations disposal, timely capture emerging and potential problems and formulate corresponding disposal plans. (Provincial Bureau of Statistics, Provincial Department of Education, Provincial Department of Human Resources and Social Security, Provincial Development and Reform Commission, Provincial Economic and Information Committee, Provincial Agricultural Committee, Provincial Department of Commerce, Provincial Administration for Industry and Commerce, etc.)

  (twenty-four) to prevent and resolve unemployment risks. People’s governments at all levels should establish a rapid response mechanism, form a work plan to deal with large-scale unemployment, and study and determine emergency policies and measures after risks may occur according to the early warning level. Especially when the new employment in cities and towns drops sharply and the unemployment rate rises sharply, it is necessary to ensure that all preparations for dealing with risks are in place in time, try to resolve risks in the bud as much as possible, and ensure that there is no large-scale laid-off tide and large-scale group incidents. (Provincial Department of Human Resources and Social Security, Provincial Development and Reform Commission, Provincial Department of Finance, Provincial Civil Affairs Department and Provincial Administration for Industry and Commerce are responsible)

  Hunan Provincial People’s Government      

  September 30, 2017       

  (This piece is made public voluntarily)

通过admin

National Health Commission: The mortality rate in novel coronavirus, China is 2.1%.

  China news agency, Beijing, February 4 (Reporter Li Yanan) The National Health and Wellness Committee of China held a press conference on the 4 th to further strengthen the medical treatment of severe pneumonia patients infected by novel coronavirus. Jiao Yahui, deputy director of National Health Commission Medical Administration and Hospital Authority, said that as of 24: 00 on February 3, the mortality rate of pneumonia infected by novel coronavirus in China was 2.1%.

  "According to the fatality rate of confirmed cases, as of 24: 00 yesterday, the cumulative number of confirmed cases of pneumonia in novel coronavirus was 20,438, and the cumulative death was 425. According to this figure, the national mortality rate, that is, the mortality rate of confirmed cases is 2.1%. " Jiao Yahui introduced that the death patients were mainly concentrated in Hubei Province, with a total of 414 people, accounting for 97% of the country. The mortality rate of confirmed cases in Hubei Province was 3.1%.

  "In addition, the death toll in Wuhan is 313, accounting for 74% of the national death toll, and the mortality rate in Wuhan is 4.9%. The mortality rates in Hubei Province and Wuhan City are higher than the national level. If the mortality rate in other provinces except Hubei Province is removed, it is 0.16%." Jiao Yahui said that from this set of figures, we can see that the main deaths are still in Hubei, mainly concentrated in Wuhan. For other provinces in the country, although there are many cases, the mortality rate is actually quite low.

  "From this point of view, we are still confident. Most of our cases are still light cases, so there is no need to panic." She said.

  Jiao Yahui pointed out that the national mortality rate is basically stable, now it is 2.1%, and it was 2.3% at the beginning of the epidemic, which can be said to be a slight decline. According to the analysis of the death cases, the majority of them are men (2/3) and women (1/3), and most of them are elderly. More than 80% of them are elderly people over 60 years old, and more than 75% of them have one or more basic diseases, and these basic diseases are cardiovascular and cerebrovascular diseases, diabetes, and some patients have basic diseases such as tumors.

  Jiao Yahui said that for the elderly who are old and have basic diseases, as long as they are infected with pneumonia, it is a high-risk factor in clinic, and the mortality rate itself is very high, not because they are infected with pneumonia in novel coronavirus.

  When talking about the current situation that the mortality rate in Wuhan is significantly higher than that in other provinces in China, Jiao Yahui analyzed that the severe patients in the early stage were mainly admitted to three designated hospitals, and the capacity of these three designated hospitals was far from enough. Other critically ill patients are scattered in more than 20 medical institutions, and the principle of "four concentrations" has not been fully implemented. These patients are scattered, which is not conducive to management. In addition, they are not managed by medical teams specializing in critical medicine, so the strength of high-quality medical resources is diluted to some extent, which is also a factor leading to a high mortality rate of critically ill patients.

  She introduced that now, an independent hospital area of a third-class general hospital has been newly recruited as a designated hospital for treating critically ill patients, and a team of academicians has been organized to make rounds, and a national high-level hospital has been organized to take over the management of critically ill patients in these hospitals, and a series of systems have been established, including the patrol system of academicians, the multidisciplinary comprehensive treatment system and the holistic nursing system.

  "At the same time, we have to do a good job in the rotation of medical staff, especially in the diagnosis and management of severe patients. The ratio of human resources needed is more than that of mild patients and ordinary patients, and the work intensity is very high, so it is necessary to increase the rotation, because it is also a very important measure to ensure the physical and mental health of medical staff. We hope that by adopting these comprehensive measures, we can exert the effect as soon as possible. I believe that it will not take long for this effect to appear, and the mortality rate in Wuhan should gradually decline. " Jiao Yahui said. (End)

通过admin

Mathematics is a game for young people? This Chinese, who is over the age of ancient times, has also solved one "Millennium problem".

Everything is counted.

From the literary point of view, every mathematician has his destiny. Euclid’s eternal name lies in geometry. Zu Chongzhi’s lasting legacy lies in pi. If Newton was not proficient in mathematics, even if he was knocked unconscious by a falling apple, he would not realize gravity. Similarly, if Gauss didn’t invent Gauss algorithm and Gauss function, how can he be called "prince of mathematics"? What people think of Hilbert today is undoubtedly his 23 "Hilbert problems" and his self-confidence as clear as mathematics: "We must know. We will know. " Chen Jingrun, a bookworm, has become a household idol, all because of Mr. Xu Chi’s Goldbach Conjecture.

Zhou Congyao was born for mathematics, which is a gift and a private gift from God.

God not only gave him talent, but also gave him the soil to grow up in. It is a small place, Donggou, Funing County, Jiangsu Province, which is unknown.

Zhou Congyao entered Donggou Middle School, a small school with poor resources, but he met Pan Bingjie, an exceptional wizard, who was born as a cowherd, didn’t graduate from primary school, and taught himself. He worked all the way from the first-generation teacher to the third-year math teacher and the teaching director of Dongzhong Middle School.

Under the guidance of Mr. Pan, Zhou Congyao came to the fore in junior high school. In 1962, a math contest was held in Beijing. Participants are limited to senior two and senior three students. In the final game, the best is chosen, and the best is chosen. Therefore, the difficulty coefficient is particularly large. Hua Luogeng (director of the competition Committee) predicted: "Whoever can score 60 points will have the hope of winning the championship."

Tang Shouwen, a senior three student in Beijing No.65 Middle School, won the prize in themoon: he scored 86 points in the exam! Hua Luogeng was overjoyed and specially hosted a banquet for Xiao Tang at home as a reward.

Hua Luogeng didn’t know that Zhou Congyao, a junior three student in Donggou Middle School, thousands of miles away, could get more than 60 points in this set of questions!

高中,整体起飞。当地土话讲:“兵怂怂一个,将怂怂一窝。”反之亦然:“学生强强一个,老师强强一班。”周从尧是六五届,他考进了清华,是七人之一。但是,进数学系,而且执着终生,步步踩在命定的数上,则是唯一。

天才碰上了“文革”,这是“无理数”。大学毕业分配到湖南西洞庭湖农场,人们领略了他的数,体力加毅力的数:吃饭,最多能吃十七个馒头;挑担,能挑三百六十斤;插秧,有同学戏称其为“插秧机”。

得其所哉!是在农场再分配之后,周从尧进入了湖南计算技术研究所。倘若把周从尧比作冰山,世人只晓得他露出海面的部分:获奖专业户。国家级的,有全国科学大会奖、国家科技进步奖;省部级的,六项,具体名称略;市级以下的,举不胜举。

世人不晓得的,自然是海面下的部分:理论数学研究。这是他的挚爱。那些年,他在纠缠华林猜想。

这是18世纪的老问题,祖父的祖父的祖父级的了。我国参与这一问题研究的,前有华罗庚,后有陈景润,都取得了阶段性的成果。1982年,周从尧在陈景润的基础上又有突破。但在公布时间上,比印度学者晚了一步——科学研究没有亚军可言,他只有继续潜回水底。

In those years, Zhou Congyao and I were both assigned to Changsha, so we knew it very well. Then, I returned to Beijing. Then, at the beginning of the 21st century, Zhou Congyao retired and moved to Beijing for a long time. What we talked about the most was literature. Wilstrass said that a mathematician who is not a bit poetic will never be a complete mathematician, and he believes it. Of course, I often talk about mathematics. For me, it is a supplementary course and an extension. If I use the words of Wilstras flexibly, I can write: a writer without "numbers" in his mind will never be a writer in the perfect sense.

Time flies, and we are both in our twilight years. Listening to him, he said that he is still tug-of-war with mathematics. Let’s take it as inertia. I think, just like me, despite the decline of my memory and the exhaustion of my thinking, I still write and draw and enjoy myself every day.

Until one day, in June, 2019, Zhou Congyao told me that he published a paper in China Science and Technology Papers Online, which was highly praised by his peers. I asked him how to use the high method, and he showed me the original text: "The author first discovered and proved the most practical negation of congruence judgment by elementary methods, without BSD conjecture. The proof process is novel and unique, and it has great innovation in theory … It is a good innovative research paper on number theory research. " This surprised me.

Hardy said that mathematics is a game for young people. When he said this, he was old and was writing sad memories. There may be exceptions (that is God’s privilege), but it can’t be wrong in general, so there is a hard rule in the Fields Prize: the winner should not be over 40 years old.

At this time, Zhou Congyao is over the age of ancient times.

Remember a shot: besides mathematics, Zhou Congyao likes painting and inherits his grandfather’s genes. I also like walking, out of healthy instinct. He lives in the Second Ring Road and often walks and thinks along the streets. One day, I drove by Andingmen and saw him holding his head high and striding on the sidewalk. At that time, I stared at his white hair, which was really white, as white as snow! Then, staring at his fast-moving back, it was really fast, as fast as the wind! This is not painting, not photography, but-mathematics, pure and clear mathematics.

Then, good news kept coming, and he threw out five papers in a row. The last article, the sixth article, was published in March, 2021, with the title of "Major Improvement of Fermat-Guan Xungui’s Discrimination Theorem of Congruence and Ten New Algorithms". His six papers include more than 25 theorems, a criterion, a new function, two postulates and ten new algorithms. It can be said that in this direction, he has climbed to a relative peak. Although he found ten new algorithms at a time, he solved many types of congruence calculation; But he also found that more difficult problems followed. This kingdom, like a universe, is boundless. Colleagues-naturally also encountered new troubles-I don’t know how to express it.

Waiting, only waiting for the authoritative referee. Zhou Congyao didn’t have time to wait, so he wrote a pamphlet "past lives with Remainder in Millennium Problem" to popularize science.

通过admin

Is the "pocket girl" in Suining, Sichuan abused by her mother to gain traffic? Joint investigation team: not true.

  Cover journalist Liu Hu Respondents for the picture

  On the evening of December 12th, Chen Moumou, a "pocket girl" in chuanshan district, Suining, Sichuan, was suspected of being abused, which triggered a heated discussion. As can be seen from the video posted on the social account of the "Pocket Girl" mother, her mother is suspected of provoking her by pinching her face, lifting her up and turning around, making her beat and scold others and break things. After the video was sent out and attracted attention, her mother was questioned for deliberately hurting and abusing the girl in order to gain traffic and attention.

Video screenshot of Chen Moumou suspected of being abused

  On the 13th, the cover news learned that after the incident caused concern, the local disabled persons’ Federation, civil affairs and other departments jointly went to Zhaizi Village, Longfeng Town, where the "Pocket Girl" family lived, and found out that it was not true that Chen had been abused.

  It is understood that the "pocket girl" in the video, Chen Moumou, is 35 years old and is a multi-level disabled person.

  "By visiting his parents, village cadres and the surrounding people, it is reflected that Chen’s intelligence is about the same as that of a two-or three-year-old child. His words are unclear and he can’t accurately express his thoughts. He has been grumpy and emotionally unstable since childhood and only sticks to his mother." In response to the cover news, the joint investigation team said that although the mother in the video reprimanded Chen, "it is not the so-called abuse on the Internet."

"Pocket Girl" Chen Moumou (left) and his family

  At present, the social account "chuanshan district Xiaoxiao Food Business Department" that posted videos has been banned. It is reported that this is the second time that the account has been banned by netizens.

  In 2020, Chen’s mother registered the account of "chuanshan district Xiaoxiao Food Business Department" on the social platform. His own cultural level is not high. At first, he only recorded his daily life. Later, he expected to sell his own honey by publishing videos on short video platforms to increase his income.

  In August 2022, the cadres of Longfeng Town and local village cadres found that some videos posted by the account were inappropriate, so they educated and guided Chen’s mother and deleted some inappropriate videos. But in recent six months, some online celebrity contacted her actively and invited Chen to participate in the live broadcast. After repeated communication between cadres and their families, "chuanshan district Xiaoxiao Food Business Department" did not release the video for more than one month.

  In addition, the joint investigation team indicated that chuanshan district Civil Affairs Department, Disabled Persons’ Federation, Women’s Federation and other departments have given Chen’s family policy support such as subsistence allowance, living allowance for the disabled with difficulties and nursing allowance for the severely disabled since 2011, and the family has enjoyed all kinds of national policy support for more than 12 years, thus enjoying the enjoyment.

通过admin

Honeysuckle decoction can fight swine influenza virus.

  On October 7th, Zhang Chenyu, Dean of School of Life Sciences of Nanjing University, published an article in the top international academic journal Cell Research, revealing that a plant microRNA (MIR2911) directly targets influenza A virus, including H1N1,H5N1 and H7N9. Honeysuckle is rich in this kind of microRNA. After ingesting honeysuckle decoction, mice can reduce the mortality rate of various influenza viruses including H5N1 and prevent them from being infected with influenza A virus.

  Zhang Chenyu introduced that plant microRNA is a kind of noncoding RNA with a length of about 19-24 nucleotides. In previous studies, the team has confirmed that those plant microRNA stably existing in mammalian serum and plasma are actively secreted by tissues and cells, which can be used as new biomarkers of diseases and play the role of intracellular molecular signal transmission.

  The project team found that MIR2911 can be selectively enriched in honeysuckle decoction, and after drinking honeysuckle decoction, MIR2911 can be delivered into plasma and lung tissue. They also confirmed that MIR2911 can inhibit a variety of influenza viruses by targeting two genes, Pb2 and NS1, which are essential for influenza virus replication. Moreover, both synthetic MIR2911 and endogenous MIR2911 in honeysuckle decoction can effectively protect animals from H1N1 infection, and this protection depends on the binding site of MIR2911 on PB2 or NS1 gene. MIR2911 can also effectively inhibit the replication of influenza viruses H5N1 and H7N9, which indicates that it has broad-spectrum anti-H1N1 effect.