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Pentium pony strives to create a new life with smart driving, which one is more cost-effective?

Although cars can improve the convenience of people’s travel, safety is still an unavoidable topic. Therefore, many car companies have begun to upgrade the safety of their models. Of course, for consumers, a car with complete active and passive safety configurations will be more popular. The richness of a car configuration is related to the user’s car experience, so many people are concerned about its configuration today. Let’s take a look at it next.

First of all, from the appearance, the design style of Pentium pony head has taken a steady route, which is very sporty. Headlights are simple and fashionable, and the design is more fashionable and dynamic. The car is equipped with etc. Coming to the side of the car body, the size of the car body is 3000MM*1510MM*1630MM, and the car adopts simple lines, which gives people a very streamlined feeling. With large-sized thick-walled tires, the shape is eye-catching. In the design of the rear end, the overall shape of the rear end of the Pentium pony echoes the front face, and the taillights look very comfortable and have a rounded shape.

When I came to the Pentium pony car, the interior shape looked very simple and the overall shape was remarkable. The car looks very good outside the steering wheel, made of plastic, showing a sense of atmosphere. Take a look at the central control. The design of the center console is reasonable, which makes the interior style impressive and has a certain sense of science and technology. The dashboard and seats are equally eye-catching. The dashboard of the car presents a simple design style, highlighting the trendy temperament. The car uses fabric seats, which are wrapped in place and are basically enough for daily use.

Pentium pony matching gearbox, 30KW, 90N.m, good power performance.

The car is equipped with Bluetooth /WIFI connection, sunshade mirror, USB interface, uphill assist, rear reversing radar and other configurations, and the configuration performance is passable and basically satisfactory.

After reading the above introduction, let’s make a summary. Such a car with the right price is enough to meet the daily practical needs, and it doesn’t take much thought to maintain it at ordinary times, and the cost performance is good.

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Nakamura Shido dumped Meisa Kuroki and cohabited with a handsome white-collar woman.


Nakamura

    Nakamura Shido, a Japanese kabuki actor who has appeared in films such as Red Cliff one after another and is well known to China audiences, has recently been found to be madly in love with a female white-collar worker who graduated from Waseda University, even to the point of talking about marriage. According to FRIDAY, a photo magazine published on January 14th, 38-year-old Nakamura Shido was photographed buying a wedding ring with a 27-year-old female white-collar worker, thus speculating that Nakamura is about to enter the marriage hall for the second time.

    Nakamura Shido, who divorced actress YUUKO TAKEUCHI in 2008, has a son with his ex-wife, Takeuchi, who is now 5 years old. After the divorce, Nakamura was once rumored to be in love with 22-year-old Meisa Kuroki, but both denied it.

    According to the new issue of FRIDAY, the rumored girlfriend who is in contact with Nakamura has a short hair style, and the whole person looks particularly handsome. After graduating from Waseda University, she worked as a magazine graphic model during her school days, and became a white-collar worker of a silver jewelry brand company after graduation. On January 3, the magazine photographed Nakamura and the woman going to a jewelry store in Tokyo, and Nakamura chose a wedding ring for them. From their sweet smiles, it can be seen that they are by no means ordinary men and women. The magazine also revealed that Nakamura had started living together with this woman.

    According to relevant sources, Nakamura and this woman met through a friend’s introduction at an endorsement event in the summer of 2010, but the marriage was denied by this insider. "I don’t think it will be so soon … …” . After the divorce, Nakamura always avoided talking about emotional topics, but in recent interviews, Nakamura changed his previous avoidance attitude. When asked if he would get married within the year, Nakamura once said with a smile: "I will work hard!" The words reveal the expectation of remarriage.

[Movie Network]www.1905.com Exclusive manuscript, please indicate the source.

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Late-night construction also brings dust rolling? These problems that plague people’s lives have been …

Original title of this article: "Does the construction in the middle of the night bring dust rolling? These problems that plague citizens’ lives have been dealt with! 》

Dear friends,

The weekly [Echo] is coming again!

The mixer truck raises dust and the construction noise at night is loud?

Lack of road control, there are great security risks?

The school gate will be flooded whenever it rains, making it difficult to pass?

……

This week’s [Echo]

Continue to solve your problems!

reply

(No.39, 2018)

???

01

User message content

Longxi Mountain, Gaoyao Country Garden, rushed to work day and night, and 2 tons of cars were forbidden to pass through this section. The mixer still shuttled through Cologne Street at 2 or 3 in the morning, raising a lot of dust, and did not sprinkle water on the road to reduce dust, which had a great impact on the life and travel of nearby residents. The dust was rolling during the day and the noise was constant at night. I hope the relevant departments would pay attention to it.

Gaoyao district Committee office

answer

After verification, netizens reported that the situation was true. The construction unit has implemented water spraying and dust removal, but the frequency is not enough, and the dust removal effect is not ideal.

On October 26th, a joint working group was formed by the departments of housing, construction, environmental protection, transportation and traffic police in our district. The person in charge of the Longxi Mountain construction project in Country Garden and the person in charge of the construction unit were interviewed, and the situation reflected by the netizens’ messages was reported to the person in charge. The project construction party was required to strictly abide by various rules and regulations to carry out construction and production according to law, reasonably arrange the construction time, and limit the impact of environmental pollution problems such as dust and noise on the surrounding residents to the greatest extent. It is strictly forbidden to overload and carry vehicles. That night, traffic, traffic police and other departments set up cards around "Country Garden Longxi Mountain" to enforce the law, and rectified the traffic violations of dump trucks, and the rectification action received certain results.

On October 27th, the working group formed a rectification plan on relevant issues as follows:

First, it is forbidden for the construction unit to carry out construction at night (from 22:00 pm to 6:00 am the next day), and the District Housing and Construction Bureau is responsible for supervision. If the construction at night is found, it will be ordered to stop work immediately for rectification.

Second, because the traffic of trucks over 2 tons is restricted in Cologne Street, construction vehicles must bypass the construction site through other roads to avoid dust and noise disturbing people, and the traffic police and transportation departments are responsible for supervision; The District Traffic Police Brigade carries out technical maintenance and upgrade of monitoring equipment in Cologne Street, and the District Transportation Bureau urges the owner to install weighing equipment at the cargo loading site and assign special personnel to manage it.

Third, the construction unit is required to increase the frequency of sprinkling water to reduce the dust on the road section, and the district environmental protection bureau is responsible for supervision.

In the next step, housing, construction, environmental protection, transportation and other departments will establish a linkage mechanism, strengthen joint law enforcement, conduct night inspections, and severely punish violations found. The traffic police department will implement the service system and increase the patrol monitoring of this section by setting up cards and taking irregular measures.

02

User message content

1. On the Hengda Haoting section of Dinghu 321 National Road, even if you can enter the auxiliary road after turning around from west to east, there is no municipal road that can turn into Hengda Haoting. Every day, many people from Duanzhou to Dinghu turn around here and then take the path next to the gas station to enter Hengda Haoting Road. Because it is not a municipal road, the road surface is not maintained and there is no safety control, which has great security risks. It is recommended to improve it!

2. Since the construction of National Highway 321, Xinyuan No.1 Street in Dinghu District has been flooded in every heavy rain, especially when typhoons such as Tiange and Mangosteen arrive, and even the flooding depth is more than 1 meter. The surrounding residents have repeatedly reported their problems to the petition offices and sub-district offices, but they have not received any reply or rectification.

Dinghu district Committee office

answer

(I) About the problem of netizens reflecting the section of Evergrande Haoting.

It is understood that the path that enters Taihe gas station after the U-turn of Hengda Haoting section of National Highway 321 is not a municipal road, but is owned by the gas station. The person in charge of the commercial gas station has no intention to maintain the path at present. Next, our district will strengthen the safety supervision around this section in conjunction with the traffic police department to ensure the travel safety of surrounding residents.

(2) About netizens reflecting the flooding problem in Xinyuan Street.

It is understood that due to the influence of Typhoon Mangosteen No.22 this year, from September 16 to 18, heavy rain continued to fall in our area, with local heavy rain, and the maximum rainfall recorded at Kengkou was 269 mm. Xinyuan First Street was one of the areas where flooding occurred.

During Typhoon Mangosteen, the rainfall lasted for a long time and was heavy, which greatly exceeded the design capacity of urban sewers and drainage standards, making it difficult to drain the rainwater on the pavement in a short time, and flooding occurred in many places in the area to varying degrees. Xinyuan 1st Street mentioned in the letter must be flooded in heavy rain after the construction of National Highway 321. The reason is that the elevation of the road surface has been improved after the urbanization of National Highway 321, which makes Xinyuan 1st Street relatively low-lying and prone to flooding.

In view of this situation, our district will speed up the construction progress of Xinshengtian Canal, complete the project construction as soon as possible under the premise of ensuring the quality, and strive to put it into use as soon as possible, so as to reduce the drainage pressure of urban sewers and reduce the flooding problem during the torrential rain in the district. In addition, the water department of our district has organized the construction team to comprehensively clear the municipal sewers of Xinyuan First Street and surrounding roads to ensure the smooth drainage of sewers in this area. In the next step, our district will refer to the vertical of surrounding roads and other factors, and appropriately adjust the ground elevation of Xinyuan Street to minimize the problem of road surface water accumulation.

03

User message content

1. The road at the gate of xinhua primary school will be flooded whenever it rains, and the water depth is more than 20 centimeters. Primary school students cannot pass after school, so parents need to carry it. I hope the relevant departments will go to the field to investigate and study solutions.

2. Two fans on the Blue Sky Water Gathering Building of Duanzhou Shanghai City Phase II roared for 24 hours. Standing on the balcony, I felt my ears tingle. I didn’t even dare to open the doors and windows at home. I couldn’t sleep when I opened the windows. I have reported to various departments that no one has handled them many times. Blue Sky Shuihui is a clubhouse, which is opened so close to the community. It is not legal at all. A few days ago, I heard the voice of singing K in the middle of the night.

Duanzhou district government office

answer

(1) About the problem that netizens report that the road at the entrance of xinhua primary school will be flooded when it rains.

According to the field investigation, xinhua primary school is located on the land on the east side of Xinghu Avenue and the north side of Donghu Road, which is lower than the municipal roads. The road at the entrance of xinhua primary school belongs to the village road, and drainage pipes and wells have not been built around it. The urban drainage network management center regularly cleans and maintains the municipal drainage pipelines of Xinghu Avenue and Donghu Road to keep the pipelines unblocked. However, due to the lack of supporting drainage facilities and municipal drainage pipelines around xinhua primary school, and the fact that it is located in a low-lying area, rainwater cannot be drained when it rains, so it is easy to form flooding in rainy days. Our district has urged Huanggang Sub-district Office to organize Fenggang West Village to do its best to do the pumping and drainage work of this section in rainy days, and dredge the drainage channels to reduce the impact of stagnant water.

As the north side of xinhua primary school is reserved land for the expansion of Honghu Lake, it will be built by the Municipal Construction Bureau. The next step in this area will be drainage planning and construction together with Honghu Lake, which is transferred to the east. After the drainage network in this area is improved, the flooding problem of the road at the entrance of xinhua primary school can be completely solved.

(B) About the problem that netizens reported that the noise of Shanghai Blue Sky Water Club Phase II disturbed people.

Upon investigation, the name of the place mentioned in the complaint is Duanzhou Blue Sky Holiday Leisure Center (hereinafter referred to as "Blue Sky Shuihui Club") registered in the administrative department for industry and commerce. Duanzhou Sub-bureau of City Comprehensive Law Enforcement Bureau received a report on the disturbance caused by the fan noise of Blue Sky Shuihui Club in early June. After repeated urging by law enforcement officers on June 8, July 11, July 17 and August 6, the club moved two fans on the roof that were originally close to residential buildings to the direction of the road, and connected the extended air ducts of the fans to the sound isolation box, which significantly reduced the noise.

According to the situation reflected by netizens, Duanzhou Branch of the Municipal Comprehensive Law Enforcement Bureau and the District Cultural and Sports Bureau sent law enforcement officers to the scene for mediation. On-site inspection found that in order to reduce noise and avoid noise spread, the club also closed the kitchen window. On the morning of October 10th, law enforcement officers contacted the relevant complainants by telephone to inform them of the handling situation and will monitor the noise of Blue Sky Holiday Leisure Center together with the municipal environmental monitoring station. The complainant expressed satisfaction and understanding of our work.

In the next step, our district will urge Duanzhou Branch of the Municipal Comprehensive Law Enforcement Bureau and the Municipal Environmental Monitoring Station to monitor the noise of the clubhouse as soon as possible, and follow up according to the monitoring report.

04

User message content

The industrial zone on the west side of Xiangang Toll Station often uses night time to secretly discharge harmful waste gas and smoke, which causes people living nearby to have difficulty breathing and seriously affects their health! We have repeatedly complained ineffectively, and now we question whether there is a problem with the efforts of the functional departments to implement the national environmental protection policy.

Gaoyao district government

answer

Recently, the environmental protection bureau of our district has received two complaints about the waste gas pollution in the industrial zone on the west side of the Xian Gang toll station, which the district environmental protection bureau attaches great importance to. Since the beginning of this year, in response to the problem of waste gas pollution in Xiangang Industrial Zone, the District Environmental Protection Bureau has repeatedly conducted surprise inspections with the People’s Government of Xiangang Town on enterprises in the industrial zone, and filed investigations on 14 enterprises with environmental violations, which severely cracked down on environmental violations of enterprises in the region. At the same time, since the creation of our district, the government of Xiangang Town has established a grid system, strengthened supervision and inspection of enterprises in the industrial zone, and required relevant enterprises to implement the environmental management system.

After receiving complaints from the masses, on the evening of October 10, 2018, the law enforcement officers of the District Environmental Protection Bureau, together with the staff of Gaoyao District Environmental Protection Monitoring Station and third-party testing institutions, went to the complaint area to conduct supervision and inspection, and sampled and monitored the ambient air at the northeast side (near the exit of the toll station), south side (in the junior middle school) and west side of the complaint area, and will focus on tracking and inspecting the enterprises near the relevant area according to the results of the ambient air monitoring report.

At the same time, the enterprises involved in waste gas emission and producing at night (Zhaoqing Gaoyao Hongzhan Hardware Plastic Co., Ltd., Chongqing Gaoyao Jinyi Aluminum Co., Ltd., Zhaoqing Gaoyao Zhaoxing Industry and Trade Co., Ltd., etc.) were monitored for waste gas. During the inspection, law enforcement officers found that the exhaust gas collection in the drawing and granulating workshop of Hongzhan Hardware & Plastic Co., Ltd. in Gaoyao District of Zhaoqing City was not perfect and the workshop was irritating, so they immediately asked the company to stop production and rectify. The next day, the district environmental protection bureau issued a notice to the company to stop production and rectify, requiring the company to resume production after the rectification is completed and reported to the bureau for inspection.

In the next step, the District Environmental Protection Bureau will continue to strengthen the supervision and inspection of gas-related enterprises in the industrial zone on the west side of the Xiaogang toll station, and intensify inspections. Once suspected environmental violations are found, they will be seriously investigated and dealt with according to law. At the same time, the district environmental protection monitoring station and third-party testing institutions are required to increase the frequency of spot checks and monitoring of gas-related enterprises near the complaint area, and investigate the enterprises suspected of exceeding the standard discharge according to law.

That’s all for this issue.

If the neighbors have problems to reflect

Then leave us a message ~

Please ask the neighbors to reflect the problems in the [Suggestions] column with evidence and facts, otherwise it will easily lead to a waste of public resources. Thank you for your support!

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For some netizens’ suggestions with clear views, true information, focusing on a single theme and relative depth, they will be selected separately and submitted to the relevant leaders of the municipal party Committee and municipal government for reference.

To netizens

We will continue to increase the tracking efforts.

Answer your question with [Echo]

At the same time, we will continue to pay attention to the follow-up handling.

Welcome the general public to supervise!

Zhaoqing fafa editorial department

Data collation Cai Tingting

Trainee editor Mo Sha

Editor-in-Chief Tang Qianyu

Editor Zeng Shanjie

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Is cell therapy reliable in treating cancer? CAR-T leads the world, and 10 popular and emerging cellular immunotherapy show their magical powers!

The incidence of malignant tumor is increasing year by year, which has become a common problem faced by human beings. Traditional treatment methods such as surgery, traditional chemotherapy and radiotherapy have always played a leading role in cancer treatment, but the effects of these treatments are limited. In particular, it is difficult for advanced patients to benefit from these treatments for a long time, nor can they fundamentally solve or change their quality of life. Therefore, researchers are increasingly focusing on the field of immunotherapy. Immunotherapy has brought new opportunities and hopes for the treatment of tumors, among which Immunocheckpoint inhibitors, therapeutic antibodies, tumor vaccines, immunomodulators, adoptive cell therapy, etc. Significantly improved the prognosis of cancer patients, and some patients with advanced cancer obtained long-term survival. In the past two years, many cellular immunotherapy have emerged and developed rapidly, which undoubtedly set off a wave of cancer treatment. So, is cell therapy reliable in treating cancer? In fact, immunotherapy has a history of more than 100 years, and it has only gradually entered the public’s field of vision in the last two years, and it has been absolutely recognized by the world oncology community.   

20731650935352411   

A milestone in the history of cancer immunotherapy In 2013, Science magazine ranked the top ten scientific breakthroughs of the year, and immunotherapy topped the list. In recent years, immunotherapy is one of the hot spots in the research field of tumor treatment at home and abroad, and a large number of clinical studies have shown exciting results. Among them, Cellular immunotherapy uses the self-protection and killing ability of human immune system to achieve anti-tumor effect. Cells with immune function in patients are cultured and proliferated in vitro, and they are given the ability to attack tumor cells by technical means, and then they are imported into patients to realize their own anti-cancer. This therapyAgainst immune cells, not cancer cells.It is not as harmful to the patient’s health as surgery, radiotherapy and chemotherapy. Patients with early cancer can be treated directly, especially with the attack on residual cancer cells after surgery. Judging from the rapid development in scientific research and clinic in recent years, cellular immunotherapy is expected to become the fourth pillar of anticancer therapy in terms of accuracy, effectiveness and safety. Next, the small series of Cancer-free Home gives a general introduction and inventory of a variety of popular and emerging cellular immunotherapy in the biomedical industry, hoping to give cancer friends a general understanding of the general development process of this cancer treatment field. 

0one  CAR-T cell therapy

CAR-T therapy is chimeric antigen receptor T cell immunotherapy, which is a new precise targeted therapy for treating tumors. T cells are activated by genetic engineering technology, and the positioning navigation device CAR (tumor chimeric antigen receptor) is installed to transform the ordinary "warrior" of T cells into "super warrior" CAR-T cells, Specially identify tumor cells in vivo and kill tumor cells efficiently. So as to achieve the purpose of treating malignant tumors. At present, with 2021, Aquilencel injection, Regioscel injection. It was approved for listing in China, in 2022.Cedarchiorense was approved for listing by FDA.CAR-T therapy is expected to enter the blowout period. Indeed, CAR-T technology has shown good curative effect in many hematological tumors, such as leukemia, lymphoma and multiple myeloma, and more than half of hematologic cancer patients who are on the verge of despair and have no cure have achieved good curative effect.  

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CAR-T cell therapy has been listed at home and abroad at present.

Although the clinical effect of CAR-T therapy on solid tumors is not satisfactory, and it has even been sung down by some people, in recent years, CAR-T therapy has made outstanding progress in the fields of gastric cancer, liver cancer and pancreatic cancer. Scholars at home and abroad have made various modifications to CAR-T, and constantly found new targets for the treatment of various solid tumors.    

Clinical study on CAR-T therapy is out of the loop.

0one Gastric cancer and pancreatic cancer As the first CAR-T cell targeting Claudin18.2 in the world, CT041 emerged as early as the ASCO annual meeting in 2019. At that time, the total objective remission rate was 33.3%, which already surprised the world. Now the more remarkable curative effect is undoubtedly the icing on the cake! This clinical data shows a good treatment prospect for digestive system tumors!

Domestic CAR-T therapy CT041 first appeared in ESMO

Developed by Keji Pharmaceutical at the annual meeting of the European Society of Oncology (ESMO) in 2021.Targeting Claudin18.2(CLDN18.2)Autologous CAR-T candidate productsCT041Showing its presenceDigestive system tumorThe outstanding curative effect can be described as brilliant!

The research data is particularly eye-catching!

1. All patients’The objective remission rate was 48.6%, and the disease control rate was 73%.All patients with gastric cancerThe total objective remission rate was 57.1%.

2. Patients with gastric cancer who failed to receive at least 2 lines of treatment in the past:The objective remission rate was 61.1%, and the disease control rate was 83.3%.

3. And the overall tolerance is good!

As of March 3, 2022,CT041 became the first and only CAR-T cell candidate product in the world for the treatment of solid tumors, which entered the confirmatory phase II clinical trial.This is a milestone for CAR-T to conquer the solid tumor field. Congratulations!

In addition, there are many CAR-T cell therapies targeting CLDN18.2.0 2 liver cancer At present, the clinical trial targets of CAR-T in the treatment of liver cancer are mainlyGPC3 (phosphatidylinositol proteoglycan 3). The breakthrough research results completed by Professor Zhai Bo, director of the Department of Tumor Interventions, Renji Hospital affiliated to Shanghai Jiaotong University School of Medicine, were published in the international authoritative journal Clinical Cancer Research on May 5, 2020. By July 24th, 2019, 13 patients had received CAR-GPC3 T cells with a median value of 19.9×108. All the patients are GPC3 positive, and they have received surgical treatment, local treatment or systemic treatment, and they all carry hepatitis B virus (HBV). Two patients achieved partial remission (PR). The 6-month, 1-year and 3-year survival rates of all patients were 50.3%, 42.0% and 10.5% respectively, and the median survival time (OS) was 278 days (39.7 weeks). At the ASCO annual meeting in 2021, Chinese medical researchers published the latest clinical research data of CAR-T drug targeting GPC3 (Ori-CAR-001) in the treatment of recurrent/refractory hepatocellular carcinoma for the first time. As of March 10, 2021, a total of 11 recurrent subjects who received cell infusion were included.All the subjects had advanced hepatocellular carcinoma, and none of them were effective after chemotherapy, TACE (transcatheter arterial chemoembolization) and targeted therapy.Of the 9 evaluable subjects,4 cases achieved partial remission (PR), 3 cases achieved disease stability (SD) and 2 cases developed disease progression (PD).The objective remission rate was 44%, and the disease control rate reached 78%.. 

02  Treatment of tumor infiltrating lymphocytes (TIL)

TILs therapy, simply speaking, is to separate and purify the lymphocytes in the tumor tissue after surgery, select the lymphocytes that can specifically resist cancer, and then amplify and activate them and reinfusion them. This kind of therapy has a history of more than 30 years, and it was first used for malignant melanoma. In recent years, it has given good data in many solid tumors such as cervical cancer and lung cancer.

This therapy is equivalent to pulling back veterans with combat experience directly from the battlefield. After a round of "political review" and "big competition" in professional ability, the spies and traitors are eliminated as far as possible, leaving the ones with the strongest fighting capacity, providing supplies, and then sending them back to the battlefield to continue fighting. Looking at the whole industry, the voice of "innovative therapy based on Tiles cells LN-144 (Lifelecel) is expected to be approved in 2022" is particularly loud. Tiles therapy, as an "ancient" cell therapy, is expected to usher in the first approved product this year, and its great potential in treating solid tumors can not be underestimated, with strong strength and relatively "out of the circle". TILs domain key node event     In 1982  

Steven A.Rosenberg and others discovered for the first time that TILs can inhibit the metastasis of melanoma cells in patients.

  1988  

The earliest attempt of TILs in clinical treatment: TILs therapy for metastatic melanoma achieved an objective remission rate of 60%.

  In 2011  

Steven A.Rosenberg and others published a phase II clinical research data in Clinical Cancer Research: the objective remission rate (ORR) and complete remission rate (CR) of patients with melanoma treated by TILs were 56% and 24% respectively.

  In 2012  

Melinda Bachini, a patient with advanced intrahepatic cholangiocarcinoma, is called the first patient to achieve complete remission (CR) after TILs therapy.

  2019  

At the ASCO meeting, the clinical results of innovative therapies LN-145 and LN-144(Lifileucel) based on TILS cells in the treatment of cervical cancer and melanoma have attracted wide attention in the medical field.FDA awarded LN-145 breakthrough therapy recognition.

  In 2021  

Phase I clinical results of TILs cell therapy at AACR meeting: among 12 evaluable patients.Non-small cell lung cancer patientsMedium,TIL therapy can achieve a total remission rate of 25%, among whichTwo patients achieved lasting complete remission.

  In 2021  

At the annual meeting of tumor immunotherapy association (SITC), the clinical research results of LN-145 in the treatment of metastatic non-small cell lung cancer (mNSCLC) showed that in 28 cases,In patients with recurrent/refractory mNSCLC,After LN-145 monotherapy,The overall remission rate (ORR) was 21.4%(1 case of CR and 5 cases of PR, including 2 cases of PD-L1 negative tumors), 12 cases were stable, and the disease control rate (DCR) was 64.3%.

03  TCR-T therapy

CAR-T cells and TCR-T cells belong to T cells modified by genetic engineering technology.Compared with CAR-T therapy, TCR-T therapy has unique advantages in the field of solid tumor treatment. TCR-T cell therapy can identify tumor-specific antigens from cell membrane surface or intracellular sources, and has entered clinical application from the initial basic immune research, showing initial efficacy in solid tumors, and has become the most likely T cell immunotherapy to make a breakthrough in the field of solid tumors! 

1、 TCR-T cell therapy in China has been approved for clinical use and has become a potential new therapy for HBV-related hepatocellular carcinoma!

At present, in addition to the global TCR-T in full swing in the research and development and clinical verification stage, China is also constantly breaking through innovation.

On December 22nd, 2021, CDE (Drug Evaluation Center) official website was able to inquire about the clinical application of "SCG101 Autologous T Cell Injection", which is a TCR-T cell therapy for specific hepatitis B virus (HBV) epitopes and a potential new therapy for HBV-related hepatocellular carcinoma (HCC).

2881650935354255

▲ Image source: CDE official website

2、 Advanced liver cancer ushered in a new dawn! TCR-T therapy makes cancer patients completely relieved.

As early as 2020 International Hepatology Conference (ILC), ADP-A2AFP, a new TCR-T therapy for liver cancer based on T cells, caused quite a stir, and also made a new breakthrough in the new therapy for liver cancer.

Among the included patients,One patient showed a complete remission (CR) in cancer progression, and the AFP of the other participants also decreased to varying degrees.This means that the experiment has made progress, and it also shows that this therapy is effective for the treatment of advanced liver cancer.

             

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All the 9 patients involved had undergone surgery and conventional radiotherapy and chemotherapy, but failed or became intolerant. Among the 4 patients who received the highest dose of treatment,One patient achieved complete remission, and CT scan showed that all the lesions in the patient disappeared, and it has lasted for more than half a year without any recurrence!

The best response of other patients (cohort 1, cohort 2) is stable. 1 patient in queue 2After one month of treatment, the volume of the primary lesion did not decrease, but the volume of mediastinal lymph node metastasis decreased obviously!       

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Therefore, TCR-T therapy targeting AFP (alpha-fetoprotein) can kill tumor cells expressing AFP. Based on the positive results of this study, researchers are expected to expand the maximum dose to 5 billion cells, and we look forward to the publication of updated data of this study!

04  CAR-NK therapy

In recent two years, in addition to CAR-T therapy, another new cancer cell therapy- Natural killer (NK) cell therapy It has also gradually attracted attention. The researchers said, NK cell As a cell anticancer therapy, it has more potential, and it may be safer, cheaper and faster. CAR-NK is to add a chimeric antibody to NK cells by genetic engineering that can recognize tumor cells and activate NK cells to kill tumor cells at the same time. 

one   The first "spot" CAR-NK clinical trial in China was approved by the Food and Drug Administration. On November 11, 2021, National Medical Products Administration Drug Evaluation Center passed an independent research and development in China. Mesothelin (MSLN) chimeric antigen receptor NK cells (CAR-NK) injection for the treatment of advanced epithelial ovarian cancer. Application for clinical trial of CAR-NK injection. According to the cancer-free home, This product is the first "spot" CAR-NK product of foreign origin in China. This also marks a new milestone in the research of immune cell drugs in the treatment of solid tumors in China! 

2  The 1-year survival rate doubled, and the curative effect of CAR-NK therapy in solid tumor increased sharply.

Recently, the journal Clinical Oncology Research published a phase II clinical trial for lung cancer. Heat shock protein 70(Hsp70) is highly expressed in about 70% of middle and advanced lung cancer. NK cells are activated by Hsp70 in vitro, which is equivalent to making NK cells meet their future enemies in vitro, "making enemies" first, and then returning them to patients, so that NK cells can formally fight with cancer cells in vivo. This method of stimulating NK cells with antigen peptides in vitro and giving them certain specificity is a hot topic in recent years.

A total of 16 patients with stage III non-small cell lung cancer were enrolled in this clinical trial. One group received traditional chemotherapy combined with radiotherapy and chemotherapy, and the other group received chemotherapy combined with Hsp70 pre-stimulated NK cell reinfusion.

The results show that:The one-year survival rate can be doubled from 33% to 67% by Hsp70 pre-stimulated NK cell reinfusion therapy combined with traditional radiotherapy and chemotherapy, and the preliminary results are encouraging.

Next, Xiaobian shows a typical successful case in combination therapy, as shown in the figure:After 1~2 months of treatment, the lung tumor completely disappeared and the curative effect has been maintained for 18 months.

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In addition to the above-mentioned clinical studies at home and abroad, CAR-NK cells also have a good effect on glioblastoma and neuroblastoma, specifically recognizing and killing breast cancer cells with high efficiency, and have a remarkable effect on multiple myeloma.

05  Dendritic cell vaccine

Cancer vaccine is a form of immunotherapy, which can prevent cancer from developing or kill existing tumors by stimulating or restoring the human immune system. Dendritic cell (DC) vaccine is a new biological therapy for malignant tumor in recent years, which has been paid more and more attention and recognized by oncologists. As an important member of the human immune defense system, Dendritic cells have the strongest antigen presenting function and are known as "sentinels" of the immune system. It is named because its cells extend outward with many dendritic protrusions. It mainly uses modern high-tech biotechnology to collect the peripheral blood of tumor patients, induce and cultivate a large number of dendritic cells in a short time in vitro, and equip them with immune cells that patients do not have, so as to accurately "target" and kill cancer cells. Not only that, It can also induce immune memory in patients, so that patients can obtain long-term anti-cancer effect.

DCVAC/LuCa is a dendritic cell vaccine developed by the United States for patients with non-small cell lung cancer.In a study on the first-line treatment of advanced lung cancer announced at the ASCO conference in 2019, DCVAC/LuCa vaccine combined with chemotherapy groupThe objective remission rate is 45%,The median overall survival time was 15.5 months, and the median progression-free survival time was 6.74 months.Reduce the risk of death by 46%!

In the Phase II clinical study of the latest novel dendritic cell vaccine DCVAC/LuCa (lung cancer dendritic cell vaccine) combined with standard carboplatin/pemetrexed in the treatment of advanced non-squamous cell (nsq) non-small cell lung cancer in 2022,The 1-year survival rate was 72.73% and the 2-year survival rate was 52.57%.By the time the data was published, the median overall survival time had not been reached. The median progression-free survival time was 8.0 months, and the objective remission rate was 31.82%.

  Prostate cancer-Provenge vaccine  

Provenge is the first vaccine approved for treatment in the United States, which initiated a new era of cancer immunotherapy.This is an autologous cell immunotherapy, which was approved by FDA on April 29, 2010 to treat asymptomatic or mild mCRPC. This approval marks the success of 20 years of unremitting efforts.In the United States, Provenge is the only FDA-approved immunotherapy for prostate cancer made from patients’ own immune cells.

  Ovarian cancer-dcvac/ovca vaccine  

At the 50th annual meeting of the Society of Gynecological Oncology (SGO) in 2019, the final result of SOV02, a phase II clinical trial, was announced: DCVAC/OvCa, an immunotherapy based on dendritic cells, was added to standard carboplatin and gemcitabine schemes for patients with recurrent, platinum-sensitive and epithelial ovarian cancer.It can prolong the overall survival (OS) of patients with advanced recurrent ovarian cancer by more than one year.andDCVAC/OvCa reduced the death risk of second-line treatment of ovarian cancer by 62%. The overall survival (OS) increased significantly by 13.4 months. The median progression-free survival rate (mPFS) increased by 1.8 months. The global phase III study will be launched soon.

Melanoma-TLPLDC vaccine

The subgroup analysis results of the phase IIb clinical trial of TLPLDC vaccine in the treatment of melanoma were published at the ASCO-SITC Clinical Immunooncology Conference in 2020.

In that population analysis follow the clinical research protocol (PT), compared with the comfort unit,The 24-month disease-free survival rate in TLPLDC treatment group was significantly improved (62.9% vs 34.8%), indicating that the relative risk of disease recurrence was reduced by nearly 50%.

In the population analysis of Intentional Treatment (ITT),There was no significant improvement in 24-month disease-free survival between TLPLDC treatment group and placebo group (38.5%) vs 27%),But in this analysis,The improvement trend of 24-month overall survival rate (OS) was stronger (86.4% vs 75.1%)..

  Kidney Cancer-Ilixadencel Vaccine  

Ilixadencel is an allogeneic dendritic cell (DC) vaccine. Research shows that,Ilixadencel combined with targeted anticancer drug sunitinib(Sotan, common name: sunitinib)First-line treatment of newly diagnosed advanced metastatic renal cell carcinoma(mRCC)Compared with patients treated with sunitinib alone, the total remission rate is doubled, the complete remission rate is higher and the remission is more lasting!

  Glioblastoma-AV-GBM-1 vaccine   On June 8, 2021, well-known foreign biomedical companies announced the release of phase II clinical trial data of their personalized cancer vaccine AV-GBM-1. The research shows that this new vaccine has great potential for prolonging the overall survival of newly diagnosed glioblastoma patients in the medium term. The median progression-free survival time of patients was 10.4 months, which was about 50% higher than the median progression-free survival time of 6.9 months in the landmark STUPP study, and established a nursing standard for newly diagnosed glioblastoma patients.     Non-small cell lung cancer-tedopi vaccine  

On April 1st, 2020, a new anti-cancer vaccine, TEDPI, achieved positive results in the phase III clinical trial of non-small cell lung cancer. After the immune checkpoint inhibitor (PD-1) was resistant or failed, all patients in the group used TEDPI vaccine in the second or third line, and the overall survival rate for one year reached 46%, far exceeding the preset 25%!

A 54-year-old patient with advanced lung cancer has rapidly shrunk (from 39mm to 23mm) after five injections of the new lung cancer vaccine. At the time of reporting, his survival time has exceeded 20.6 months, and he is still being followed up.

06  CIK cell therapy

  CIK cells, that is, Cytokine-Induced Killer (CIK), are a new type of immunocompetent cells, which have strong proliferative ability and cytotoxicity, and have certain immune characteristics. Because this cell expresses both CD3 and CD56 membrane protein molecules, it is also called NK cell (natural killer cell)-like T lymphocyte, which has both the strong anti-tumor activity of T lymphocyte and the non-MHC-limited anti-tumor advantage of NK cell. If NK cells are the "first line of defense" to protect human health, then CIK cells are undoubtedly the "precision missiles" to kill tumor cells. Especially for patients after surgery or radiotherapy and chemotherapy, it can eliminate residual tiny metastatic lesions, prevent cancer cells from spreading and recurring, and improve immunity. Therefore, CIK cells are considered as the first choice for a new generation of adoptive cellular immunotherapy for tumors. Research progress of representative CIK cell therapy     

nasal pharyngeal cancer  

Among 137 patients with nasopharyngeal carcinoma treated by CIK, 50% of them improved their survival time by 6-9 months, and among 137 patients treated by CIK, 50% of them delayed their tumor progression by 6-7 months.

32171650935355613

  liver cancer  

Among the 819 patients with liver cancer treated by CIK, 50% of them improved their survival time by 13~25 months, and among the 819 patients treated by CIK, 50% of them delayed their tumor progression by 4~7 months.

87421650935356226

  ovarian cancer  

Among 72 patients with ovarian cancer treated by CIK, 50% of them have improved their survival time by 24 months. Among 72 cases of ovarian cancer treated by CIK, 50% of ovarian cancer patients delayed their tumor progression by 14.5 months.

91721650935356659

 

carcinoma of colon

Among 126 patients with colon cancer treated by CIK, 50% of them have a longer survival time of 30 months. Among 126 patients with colon cancer treated by CIK, 50% of them delayed their tumor progression by 14.5 months.

81471650935357165

  breast cancer  

The probability that the survival time of 150 breast cancer patients treated with CIK can reach 5 years is increased to 85.7%; The probability of keeping breast cancer from recurring in 150 breast cancer patients treated with CIK within 5 years increased to 72.3%.88231650935357798

  Solid tumor  

Of the 31 patients treated with PD-1 antibody combined with DC-CIK, 2 patients’ tumors completely subsided and 5 patients’ tumors partially subsided. Of the above 7 patients, 6 patients’ effects can be maintained for 5 months. The tumors of the other 13 patients remained stable.

13431650935358461

  renal carcinoma  

Among 43 patients with advanced renal cell carcinoma treated by CIK, 50% of them can delay the tumor progression to 14.7 months.

60351650935359231

07  CAR-M therapy 

In recent years, the study of macrophages has also been paid attention to by the industry. How to activate the anti-tumor activity of these macrophages is the direction that immunologists have been working hard. CD47, an immune checkpoint on macrophages, has become a very promising hot target in the field of tumor immunotherapy.

In a recent study published in Nature Biotechnology, researchers from perelman Medical College of the University of Pennsylvania and other research institutions may have an alternative to T cell therapy to overcome these challenges. Their research shows that genetic modification of macrophages (an immune cell that devours intruders in vivo) may be the key to developing effective cell therapy for solid tumors. They were able to confirm these genetically modified expressions. The macrophages of CAR (CAR-M) can kill tumors in human samples and mouse models in the laboratory and prolong their life.   

81441650935359696   

CAR-M therapy is centered on macrophages, which devour invading cells instead of destroying them like T cells. T cells are more like Space Invaders games, while macrophages are more like Pac-Man games. Another major difference between macrophages and T cells is that they are the first responders of the body to virus infection. Historically, this poses a challenge in trying to genetically modify them to attack cancer, because macrophages are not easily transfected by standard viral vectors used in gene therapy and cell therapy.

In this experiment, the research team used genetic engineering technology to transform macrophages. They not only expressed CAR targeting HER2 antigen, but also were activated and differentiated into M1 macrophage types that promoted inflammation. In this way,These CAR-M cells can not only target tumor cells, but also change the microenvironment near tumors by secreting pro-inflammatory cytokines. They can also present tumor antigens to T cells and activate T cells’ immune response to tumors, which can be described as "killing three birds with one stone".

On March 18th, 2021, Carisma Company of the United States announced the completion of the first drug delivery to the subjects of CAR-M therapy (CT-0508) targeting Her2, marking a new era of CAR-M transformation therapy for solid tumors. In a word, taking macrophages as effector cells transformed by CAR is expected to reverse the tumor inhibitory microenvironment, so as to break through the obstacles of immune cell therapy in solid tumors. 

08  CTL (cytotoxic T lymphocyte) therapy

What cell therapy can be used as an adjuvant therapy for the majority of patients with inoperable advanced cancer? In recent years, researchers have been developing new immunotherapy schemes for these patients, including CTL(cytotoxic T lymphocytes) technology. This technology mainly uses protein, which is unique to cancer cells and has no or low content in normal cells, as bait to select the truly anticancer lymphocytes in peripheral blood, and then further improve and amplify them in vitro, and then return them to patients. MTCA-CTL immunotherapy is a new generation of biological immunotherapy model introduced in China. While ensuring the expansion of non-MHC-restricted killer NK-T cells, directional expansion of HC-restricted CD8++specific CTL cells can make its proportion in cell products reach 60% ~ 70%. The combined effect of this killer cell makes the efficiency of killing tumor cells higher.  

10991650935359999

At present, the multi-target compound antigen peptide biological immunotherapy technology, which is undergoing the second phase of clinical trials in the Cancer Hospital of China Academy of Medical Sciences, is the fifth and brand-new generation of cellular immunotherapy technology, which can optimize the activation method of DC (dendritic cells) to enhance the killing effect of immune cells on tumor cells. At present, it has achieved good clinical results and I believe it will really benefit cancer patients.

Mainly suitable for solid tumors.Head and neck tumor, esophageal cancer, lung cancer, gastric cancer, breast cancer, liver cancer, membranous adenocarcinoma, colorectal cancer, ovarian cancer, uterine cancer, coma cancer, prostate cancer, malignant melanoma, sarcoma and partial malignant lymphoma.

If economic conditions permit and you want to consult MTCA-CTL therapy, you can contact.Cancer-free Home Medical Department (400-626-9916), a detailed assessment of the condition.

09  CAR-NKT therapy

  Natural killer T cells (NKT) are a group of special T cell subsets that express both T cell receptors (TCR) and NK cell receptors on the cell surface, and can produce a large number of cytokines. Such as IL-4 and INFγ. These cells can not only directly dissolve and kill tumor cells, but also play an anti-tumor role through indirect ways (secreted cytokines, activated immune cells, etc.). Recently, a phase I clinical trial jointly conducted by Baylor Medical College in Houston and Texas Children’s Hospital is evaluating a new treatment for children with recurrent neuroblastoma –CAR-NKT cell therapy is expected to break through this bottleneck. Phase I trial, code-named GINAKIT2, used CAR-NKT cells for the first time to treat recurrent neuroblastoma. Eleven children (1~21 years old, with an average age of 7 years old) were all recurrent/refractory high-risk neuroblastoma, with extensive metastasis and no better treatment plan in clinic. The results are very encouraging: Of the 11 advanced patients, The condition of 4 patients was stable, 2 patients achieved partial remission (tumor was obviously reduced), and one of them had complete remission (CR) after receiving the second CAR-NKT cell infusion. In safety, CAR-NKT is safer than CAR-T therapy. No dose-limiting toxicity was observed in the first 28 days after infusion. 

10  Compound immune cell therapy

This technology will alsoSix kinds of cells, such as γδT cells, NK cells, NKT cells, killer T cells, dendritic cells and helper T cells.Activate, multiply 10 million to 20 million cells to 2 billion to 5 billion cells, and then inject them into patients. Cultivating such important immune cells at the same time greatly improves the therapeutic effect compared with single treatment.

Except for some leukemia and malignant lymphoma,It can be used for the treatment of most cancers, and has a good effect in refractory cancer types and advanced cancers. Besides,Compound immune cells also play a great role in improving immunity and strengthening the body.

Xiaobian has something to say

In recent years, due to the development of medical level, new cancer treatment methods have appeared one after another, among which cellular immunotherapy is in full swing, which brings new hope to cancer patients. According to the latest statistics, compared with patients with advanced lung cancer, gastric cancer and liver cancer who only receive surgery, radiotherapy and chemotherapy, adjuvant cellular immunotherapy can prolong the survival time of patients and significantly improve the data effect. In fact, tumor treatment is actually a complex "project", and it is difficult to achieve good results by relying solely on a certain treatment method. Tumor treatment needs the cooperation of various treatment methods to achieve the final victory in the fight against cancer. 

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Resume: Luxinshe

  Lu Xinshe, male, Han nationality, born in November 1956 in Juye, Shandong Province, joined the Communist Party of China (CPC) in July 1985, and joined the work in August 1982. He graduated from Wuhan Institute of Water Resources and Electric Power with a bachelor’s degree in irrigation and water conservancy engineering, and is an engineer.

  1978— In 1982, he studied in the Department of Farmland Water Conservancy Engineering of Wuhan University of Water Resources and Electric Power.

  1982— In 1986, cadres of the Land Administration Bureau of the Ministry of Agriculture, Animal Husbandry and Fisheries (during this period: November 1985.11— 1986.08 Studying at the German Training Center of Northwest Agricultural University, Ministry of Agriculture, Animal Husbandry and Fisheries)

  1986— 1990 Director and Deputy Director of the Comprehensive Registry of Cadastral Management Department of the State Bureau of Land Management (during the period: 1987— In 1988, the Federal Republic of Germany Hessian Survey Bureau and Hanover Cadastral Bureau studied; 1989.02— 1989.07 Central Party School, State Organs Branch)

  1990— 1992 Deputy Director, Cadastral Management Department, State Bureau of Land Management

  1992— 1996 Director, Cadastral Management Department, State Bureau of Land Management

  1996— 1998 Deputy Director of the State Bureau of Land Management and Member of the Party Group (1995— In 1996, he was appointed as the deputy mayor of Nantong City, Jiangsu Province)

  1998— 1999 Member of the Party Group of the Ministry of Land and Resources and Director of the Department of Cultivated Land Protection

  1999— In 2009, Deputy Minister of the Ministry of Land and Resources, member of the Party Group, Director of the State Bureau of Surveying and Mapping and Party Secretary (2005— 2008) (during this period: 2000.09— 2000.11 Central Party School Provincial and Ministerial Cadre Training Class)

  2009— In 2010, Deputy Minister of the Ministry of Land and Resources, Deputy Secretary of the Party Group, and Deputy Chief Inspector of State Land

  2010— 2011 Deputy Secretary of Gansu Provincial Party Committee and President of Party School of Gansu Provincial Party Committee

  2011— 2012 Deputy Secretary of Jiangxi Provincial Party Committee and Acting Governor

  2012— 2016 Deputy Secretary and Governor of Jiangxi Provincial Party Committee

  2016— 2018 Secretary of the Jiangxi Provincial Party Committee and Director of the Standing Committee of the Provincial People’s Congress (2017.01)

  2018— In 2019, Secretary of the Party Committee of Guangxi Zhuang Autonomous Region and First Secretary of the Party Committee of Guangxi Military Region (in April 2018)

  2019.01— Secretary of the Party Committee of Guangxi Zhuang Autonomous Region, Director of the Standing Committee of the People’s Congress of the Autonomous Region, and First Secretary of the Party Committee of Guangxi Military Region.

  Alternate member of the 17th Central Committee, member of the 18th and 19th Central Committees. Deputies to the 11th, 12th and 13th National People’s Congress. Member of the 11th Party Committee of Guangxi Zhuang Autonomous Region. Representative of the 13th National People’s Congress of Guangxi Zhuang Autonomous Region.

  (People’s Network information as of January 2019)

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How long does the rechargeable battery charge? Charging time of the rechargeable battery [Introduction]

  Abstract: Maybe everyone is very concerned about the battery, that is, how long should the battery be fully charged? This paper briefly explains that the calculation method of charging time of rechargeable battery is that the battery capacity is divided by the charging current, and then multiplied by the coefficient of 1.2 (or 1.1), and the time unit is hours.

  [Rechargeable battery charging] How long does the rechargeable battery charge? Charging time of the rechargeable battery.

  Charging time of rechargeable battery

  Maybe everyone is very concerned about the battery, that is, how long should the battery be fully charged? Many friends are worried that the lack of time and battery power may shorten the service life of the battery; If the time is too long, it may damage the phone and battery. So how long should it be charged? Here is a simple calculation method:

  Generally, the battery capacity is indicated on the battery, with mA as the unit. The larger the value, the greater the capacity.

  How long does it take to fully charge the battery? First, it depends on the nominal capacity of your battery. The larger the capacity, the longer it takes to charge. Second, it depends on how many batteries you charge at the same time. The charging time of two batteries is different from that of four batteries. Charging two batteries is twice as fast as charging four batteries. Third, it depends on the current that your charger can output. If the current is large, it will be fast, and if the current is small, it will be slow. Fourth, it depends on whether your battery is left. If it is completely dead, the charging time will be longer, and if there is still remaining power, the charging time will be shorter. There is a formula for charging Ni-MH battery: battery capacity (mA) ÷ charging current (mA) ×1.2~1.5= time (hours) required for the battery to be fully charged. Due to different chargers, the charging current is different. The charging time is generally indicated in the manual of the charger. It takes 10~20 hours for a full charge of four 2300mah batteries, 6~8 hours for a quick charge and 1~2 hours for a quick charge.

  Now all the better chargers have automatic detection function. When the battery is full, it will automatically stop charging. When it is charging, the battery is warm. After charging, it will cool after stopping for a while. The full indicator is different according to the charger, and some indicators flash when charging, and always light up when full; Some indicator lights are always on when charging, and the indicator lights go out after charging; Some indicator lights are red (or green) when charging, and turn green (or red) when full.

  Charging time of Ni-MH battery

  Calculation method of charging time of Ni-MH battery: the battery capacity is divided by the charging current, and then multiplied by the coefficient of 1.2 (or 1.1), and the time unit is hours.

  Steps/methods

  The battery capacity is divided by the charging current, and then multiplied by a factor of 1.2 (or 1.1) in hours.

  For example, if the capacity of a Ni-MH battery is 1200mA, the charging current of the charger is 600mA, and the charging time is (1200mA/600mA)×1.2=2.4 hours, then the charging time of this Ni-MH battery using this charger is 2.4 hours.

  The relationship between charging time and charging current of Ni-MH battery is that the battery capacity is divided by charging current to get the charging time. Considering the loss during charging, the calculated charging time is multiplied by the constant of 1.1 or 1.2.

  According to the logo, you can calculate an approximate time. If it is an ordinary charger and the current is small, the charging time must be very long.

  The above calculation method is not applicable to new batteries. Generally speaking, when new batteries are charged for the first three times, especially Ni-Cd batteries and Ni-MH batteries, the standard charging time is about 15 hours (0.1C), so as to maximize the service life of batteries. In the future, the battery charging time can be calculated with reference to the above method.

  How to calculate the charging time of rechargeable battery

  Generally, the battery capacity is indicated on the battery, with mA as the unit. The larger the value, the greater the capacity.

  For example, 1200mAh means that the battery capacity is 1200 mAh. At the same time, chargers are generally marked with charging current, also in milliamps.

  In this way, the charging time of the battery can be simply calculated as follows: the battery capacity is divided by the charging current, and then multiplied by the coefficient of 1.2 (or 1.1), and the time unit is hours. For example, if the battery capacity is 1200mA, the charging current of the charger is 600mA, and the charging time is (1200mA/600mA) × 1.2=2.4 hours, then the charging time of this battery using this charger is 2.4 hours.

  The above calculation method is not applicable to new batteries. Generally speaking, when new batteries are charged for the first three times, especially Ni-Cd batteries and Ni-MH batteries, the standard charging time is about 15 hours (0.1C), so as to maximize the service life of batteries. In the future, the battery charging time can be calculated with reference to the above method.

  What is the charging current indicated on the charger?

  I can give you a simple formula: charging and discharging time (minutes) = capacity *1.1/ current (mA) *60.

  The relationship between the battery charging time and the charging current is that the battery capacity is divided by the charging current to get the charging time. Considering the loss in the charging process, the calculated charging time is multiplied by the constant of 1.1 or 1.2.

  According to the logo, you can calculate an approximate time. If it is an ordinary charger and the current is small, the charging time must be very long.

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Global News | The three major US stock indexes collectively closed down. Tesla’s revenue exceeded expectations, and its operating profit declined.

[US stock index]

On Tuesday, July 23rd, EDT, the three major US stock indexes collectively closed down, with the S&P 500 index falling 0.16% to 5555.74 points. Dow Jones index fell 0.14% to 40358.09 points; The Nasdaq index fell 0.06% to 17,997.35.

American debt

On July 23, the benchmark 10-year US bond yield was 4.25%, and the 2-year US bond yield, which is most sensitive to the Fed’s policy interest rate, was 4.40%.

[Hot American stocks]

Among popular US stocks, Apple rose 0.47%, Microsoft 0.43%, NVIDIA 0.77%, Google C 0.14%, Google A 0.07%, Amazon 2.12%, Meta 0.27%, TSMC 0.31%, Tesla 2.04%, AMD 1.20% and Intel 1.26.

[global index]

index Ups and downs PT France CAC40 -0.31% 7598.63 FTSE 100 -0.38% 8167.37 Germany DAX 0.82% 18557.70 Russian RTS 0.67% 1092.67

[China index]

On July 23rd, overnight Hang Seng Technology Index futures fell by 1.88%, Nasdaq China Jinlong Index fell by 1.84%, and FTSE China A50 Index fell by 1.55%.

[China Stock Exchange]

In terms of popular Chinese stocks, Tencent Holdings (Hong Kong stocks) fell by 1.88%, Pinduoduo by 0.86%, Alibaba by 0.72%, Netease by 0.14%, Baidu by 2.06%, Ctrip by 2.20%, LI by 3.47%, Weilai by 4.37% and Xpeng Motors by 6.72%.

[foreign exchange commodities]

foreign exchange exchange rate Up and down (basis point) USD/RMB (RMB) 7.29 +1.5 bp Dollar/Euro 0.92 +2.8 bp USD/JPY 155.64 +450 bp

Commodity futures Ups and downs Latest price COMEX silver 1.04% 29.25 USD/oz COMEX gold 0.35% 2410.60 USD/oz west texas intermediate -2.36% $78.24/barrel Brent crude oil -0.36% $82.26/barrel LME copper -0.97% 9090.68 USD/ton

[Global News]

Musk: It is expected that FSD will be approved in China before the end of the year.

Elon musk, CEO of Tesla, said in the earnings conference call that he would apply for regulatory approval in Europe and China to implement the supervised FSD, and it is expected to be approved before the end of this year. (CBN)

Musk: The construction of Tesla’s super factory in Mexico is currently in a "suspended state"

Musk said that the super factory in Mexico is currently in a suspension stage. But the company will see the situation clearly after the November election in the United States. Everything depends on the political situation. Tesla will wait until the November election before deciding on Mexico’s investment.

Musk: postpone the Robotaxi conference from August to October.

Elon musk, CEO of Tesla, said that the Robotaxi conference would be postponed from August to October. Tesla will deliver cheap models in the first half of next year; It is expected that the production of Roadster sports cars will start next year. The demand for NVIDIA is so high that it is difficult for Tesla to obtain the required GPUs. We need to make more efforts in Dojo to ensure that we have the required (large model) training ability. Tesla will "double the bet" Dojo. We really need to make Dojo work.

Google will invest another $5 billion in its self-driving car business.

Porat, chief financial officer of Alphabet, said that Alphabet plans to make a multi-year $5 billion investment in Waymo’s driverless car division.

Tesla did not give a timetable for the launch of Robotaxi in the financial report.

Tesla announced its second-quarter financial report today, and the financial report did not give the specific launch time of the self-driving taxi Robotaxi. Tesla said in the financial report: "The deployment time of Robotaxi depends on technological progress and the approval of the regulatory authorities. In view of its huge potential value, we are actively grasping this opportunity. At the same time, we are managing our product portfolio with a long-term orientation, focusing on sales growth, maximizing the use of installed infrastructure, and generating enough cash flow to invest in future growth. " Earlier this month, people familiar with the matter revealed that Tesla postponed the release time of Robotaxi from August this year to October.

Google CEO Pichai: Waymo pays 50,000 trips per week.

Alphabet CEO Pichai said that Waymo paid 50,000 trips per week. More than 1.5 million developers use the big model Gemini tool. AI Overview Improve search satisfaction.

Tesla: The new car plan is still on schedule.

Tesla said that the focus of the whole company is still to reduce costs. The new car plan is still on schedule. Cybertruck production is expected to be profitable by the end of the year.

Google executives: Cloud revenue is boosted by the demand for artificial intelligence (AI)

Google executive Ruth Porat said that search contributed the most to the company’s revenue growth. The growth of the search is particularly prominent in the retail industry. Declined to comment on the company’s abandonment of Wiz acquisition. The company has been exploring the "diversity" of its portfolio by acquiring (other companies). This will be my last conference call with analysts from Google. Cloud revenue is boosted by the demand for artificial intelligence (AI).

Alphabet’s cloud revenue of $10.35 billion in the second fiscal quarter was higher than market expectations.

Alphabet’s revenue in the second fiscal quarter was 84.74 billion US dollars, and analysts expected 84.37 billion US dollars; In the second fiscal quarter, Google Cloud revenue was $10.35 billion, and analysts expected $10.09 billion; In the second fiscal quarter, Google’s advertising revenue was 64.62 billion US dollars, and analysts expected 64.53 billion US dollars; In the second fiscal quarter, other business revenue was $365 million, and analysts expected $389.6 million; In the second fiscal quarter, the revenue excluding the cost of traffic acquisition was 71.36 billion US dollars; The operating profit in the second fiscal quarter was $27.43 billion, with an estimated $26.37 billion.

Tesla’s revenue in the second quarter exceeded expectations

Tesla’s revenue in the second quarter was $25.50 billion, and analysts expected $24.63 billion; The adjusted earnings per share in the second fiscal quarter was $0.52, and analysts expected $0.60; The operating profit in the second fiscal quarter was $1.61 billion, and analysts expected $1.81 billion; The gross profit margin in the second quarter was 18%, and analysts expected 17.4%; Free cash flow in the second fiscal quarter was $1.34 billion, and analysts expected $1.92 billion; It is still expected that the sales growth rate will be significantly reduced in 2024; It is expected that the output will increase in the third quarter.

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Fax: Han Meilin’s Art "Design"

  "Inheritance and Innovation"

  — — Interpretation of Teacher Han Meilin’s Art Design Thought

  Professor and doctoral supervisor of Tsinghua University Academy of Fine Arts.

  Executive Deputy Director of China Ancient Writing Art Research Center.

  Nan Chen

  As a famous master of art, Mr. Han Meilin’s achievements in painting, calligraphy, sculpture, ceramics and other artistic fields have attracted worldwide attention. Because of his wide cross-border, profound artistic attainments, distinctive personality and great social influence, he is called "Picasso of China". In 2005, I was lucky enough to be selected by BOCOG to join the Olympic mascot creation team designed by Mr. Han. During nearly eight months of hard work and revision, I was close to the master of art and was lucky enough to be a witness and participant in this important design event in China. In 2012, I was fortunate to be the first doctoral student of Mr. Han in Tsinghua University, so that I could study Mr. Han Meilin’s artistic design thoughts more systematically, sum up his creative experience and methods, and sort out his unique educational thoughts and teaching system. There are many research articles about Mr. Han’s artistic creation, and this paper focuses on the analysis and interpretation of Mr. Han’s design thought and creative practice.

  ▲ Beijing Tourism Logo Design

  ▲ Logo design of Peking Union Medical College Hospital

  ▲ Logo design of China Organ Transplantation Development Foundation

  ▲ Logo design of National Botanical Garden

  ▲ Logo design of Canal Business District

  After repeated thinking and deliberation, the title of this article is "Inheritance and Innovation", because it is inseparable from these two closely related keywords to interpret Han Meilin’s artistic design thoughts. Teacher Han’s design achievements first come from "inheritance". For the inheritance of China’s splendid culture for thousands of years, he greedily immersed himself in this huge treasure house of art, including rock paintings, inscriptions on bronze, big seals, Han bamboo slips, bronze art, statues and ceramics … … And New Year pictures, paper-cuts, fabrics … … Those varied folk arts, just like the cross-border flexibility and diversity of his artistic creation, are embodied in "innovation", extracting and absorbing traditional culture in an open way, learning from others, and breaking through the professional barriers of various art categories. His research even includes the artistic symbols and forms of East Asia, South Asia and even Inca civilization, which are related to China’s traditional culture. It is this open way that makes "inheritance" not rigid and fragmented, but vivid and coherent with context. In the design, the rough and original brushwork of rock paintings, beautiful and smooth lines in auspicious patterns, free and easy flying white in wild grass, and bright colors in strong contrast in New Year pictures … …

  For Han Meilin’s artistic design ideas and methods, there are the following key points:

  one Han Meilin systematically inherited China’s thoughts and methods of traditional arts and crafts and artistic aesthetics, and at the same time made bold innovations on the basis of inheritance, which provided a solid foundation for him to add distinctive and high-level artistic symbol language into his design practice.

  two Han Meilin’s active thinking and creative imagination are also a major feature of his teacher. In popular words, he has "many ideas". He almost raises his head with one idea and lowers his head with another, and ideas emerge one after another.

  three Without refusing new technology and new expression language, Mr. Han never refused new computer software and all kinds of modern art tools in the process of creation. He was the first artist who used advertising markers to create ceramic hanging plates, a traditional arts and crafts form. He creatively used watercolor paper to create the effect of simulating rice paper, and cooperated with Mali Pigment to invent "China Ink Color" between traditional Chinese painting pigment and gouache. His method of using cameras and photocopiers as creation tools made me stunned. He even became interested in computer software.

  four Maintain the artist’s distinctive personality and emphasize the artist’s social responsibility. Contemporary design seems to show a trend, that is, design is gradually distancing itself from art, as if design emphasizes function and "solving problems". However, this design tendency with more or less modernist thinking is always abandoned by more and more personalized and aesthetic audiences. Originally, it was intended to please the market and the audience, but it was counterproductive. Han Meilin’s artistic design insists on ingratiating oneself with others, and attaches great importance to the social responsibility that artists should have. In a classic line from the American film Spider-Man, "The greater the ability, the greater the responsibility". He always has a strong desire to add more beautiful things to contemporary design.

  ▲ Panda Stamp designed by Han Meilin (1985)

  ▲ Han Meilin’s "Year of the Gui Hai" Pig Zodiac Special Stamp (1983)

  ▲ "Ding Younian" Chicken Zodiac Special Stamp designed by Han Meilin (2017)

  ▲ Han Meilin’s "Year of the Sea" Pig Zodiac Special Stamp (2019)

  ▲ Han Meilin’s "Year of the Gengzi" Rat Zodiac Special Stamp (2020)

  ▲ Han Meilin’s design of the Liechtenstein Zodiac commemorative stamp (2018)

  Teacher Han Meilin’s contribution in the field of art design is actually as brilliant as his other kinds of creations, but the breadth and depth of this artistic strongman’s professional involvement have a great influence, resulting in the important achievements in art design only accounting for a small category in his huge creative content, but it has reached an alarming level. Every design work is hit the floor, and even has the leading significance of design trends. From the well-known logo of Beijing’s bid for the Olympic Games, Collect and sort out the words and symbols that can’t be tested in rock paintings, painted pottery, Oracle bones and Zhong Ding to create a unique artistic font "Tianshu", the logo and fuselage interior design of China International Airlines, and the well-known mascot "Fuwa" of the Beijing 2008 Olympic Games. Mention the influence of any one of them, which is very enlightening.

  one

  Fuwa was born

  As a consultant of Beijing Olympic bid committee and Beijing Olympic Organizing Committee, Mr. Han Meilin presided over the design of a large number of important Olympic-related works during Beijing’s Olympic bid and preparations for the Olympic Games. In 2004, he was entrusted by Beijing Olympic Organizing Committee to revise the mascot design of Beijing Olympic Games. I was lucky enough to participate in some auxiliary and post-development design work, so I personally experienced and witnessed the master’s creative style. At first, there were some limitations in modifying the design. In view of the design directions selected in the solicitation activities (namely, six works of panda, tiger, dragon, the Monkey King, rattle and Ah Fu), the creation encountered bottlenecks. After several days of no breakthrough in modifying the design, Teacher Han Meilin decisively decided to jump out of the previous design concept and proposed to completely overthrow the limitations. After a heated discussion, Mr. Han Meilin stayed up almost all night, and drew a new design sketch that night — — Five cute little dolls, these images are very close to the Fuwa when they were finally released. They wear five kinds of headdresses symbolizing Jin Mu’s fire, water and soil, which are very similar to the big-headed dolls and cute tiger hats in traditional festivals. The design of these headdresses absorbs the different regional characteristics and artistic expression language of China. The major breakthrough of the scheme is that the mascot is designed as a combination of animals and characters for the first time, emphasizing that the People’s Olympics is people-oriented. If the design of the Olympic emblem represents a steady official aesthetic,Then Fuwa represents an auspicious, smooth and auspicious folk culture and art form.

  ▲ "Fuwa" manuscript

  ▲ "Fuwa"

  ▲ "Fuwa" Olympic Stamp (2008)

  ▲ Han Meilin and "Fuwa"

  Of course, the design process is quite long and arduous. After several rounds of revision and design work, the role setting of the five dolls started with "Flame, Panda, Fish, Tibetan Antelope and Dragon", and gradually replaced the Monkey King with Tibetan Antelope, and replaced the virtual animal "Dragon" with the traditional Beijing kite "Shayan". The name of "Fuwa" was determined, and the personal name "Welcome to Beijing" and special fonts in Chinese and English were also designed in homophonic form. On June 9, 2005, the 54th Executive Committee of BOCOG deliberated and adopted the revised mascot scheme. On August 18th, Mr. Verbruggen, Chairman of the Coordination Committee of the International Olympic Committee, sent a confirmation letter of the mascot to BOCOG. So far, the mascot design scheme has passed the examination of the International Olympic Committee. Industrial and commercial registration and legal protection were successfully completed by the end of October. At 20: 15 on November 11th, during the 1000-day countdown to the opening of the Beijing Olympic Games, the mascot was officially released to the world.

  ▲ Han Meilin designed the logo for Beijing’s Olympic bid.

  ▲ Han Meilin, Mrs. Han Meilin, Zhou Jianping and the logo of Beijing’s Olympic bid.

  ▲ Beijing Olympic bid sign

  ▲ Sports icons evolved from the Olympic bid logo.

  The launch of Fuwa has had a far-reaching impact on the design field of China logo and mascot, and achieved great success. In the subsequent large-scale events and international activities, the design method of serial mascots and changing colors and headdresses has become a popular trend, which has been more or less cited and used for reference in mascot design such as Taiwan Flower Expo, Guangzhou Asian Games, Singapore Youth Olympic Games and Canadian Winter Olympics. Many internationally famous cartoon characters also learn from Fuwa’s appearance and change their headdresses to cope with different festivals and activities.

  two

  Unscramble gobbledygook

  Teacher Han Meilin’s writing theme "The Book of Heaven" is unique. He focuses on the unread characters and symbols in rock paintings, pottery pieces, Oracle bones, Zhong Ding and ancient books. He collects these homeless beautiful and mysterious characters together and becomes the basis of font creation. Although many artists and designers were fascinated by the artistic creation of ancient Chinese characters in the past, the focus of Tianshu was the most original. He systematically integrated the above-mentioned unread words and symbols into a research system with theoretical depth. Culture needs to be spread and passed on through symbol carriers, and symbols will evolve continuously in the long history. If we ignore the intermediate links in this evolution, we will find that the source and structure may be very different. On the basis of paying attention to the cultural inheritance of Chinese characters, he did not simply collect and sort out records and descriptions, but added a special and unique language as his calligraphy and painting at the same time. In Mr. Han’s gobbledygook works, his artistic expression ability is fully reflected, that is, a concept has many forms. The training and cultivation of this ability has a good reference significance for the majors of logo design, creative font design and graphic design that pay attention to formal scrutiny.

  ▲ Rock Painting (Image from Ningxia Rock Painting)

  ▲ Rock paintings (pictures from the Internet)

  ▲ From the manuscript of Han Meilin gobbledygook.

  ▲ Tianshu blue printed cloth

  The development of Chinese character art and design has a vital impact on modern design in China. Today, with the serious tendency of internationalization, modern designers in China have begun to strive to establish a more influential position in the international and domestic design fields through innovation. Naturally, national vocabulary and local cultural symbols have become the objects of their efforts to explore and explore, and visual elements, cultural concepts and information symbols are numerous. Teacher Han Meilin’s "heavenly book" is a great contribution to this vocabulary excavation, and this exploration and excavation of local cultural vocabulary will definitely have an important impact on the modern design of China.

  three

  Air China Aviation Emblem and Interior Design

  The Phoenix logo of China International Airlines designed by Han Meilin occupies a landmark position in the history of contemporary graphic design in China. Today, when major international and domestic airlines have reshaped their visual images, this beautiful logo is still deeply rooted in people’s hearts because of its clear traditional aesthetics and fashion simplicity. It has stood for nearly 30 years and has become one of Chinese’s brand images with accurate conceptual positioning, the highest visibility and discrimination. The whole figure is concise and lively, with only four strokes, which are clearly distinguishable regardless of scaling.

  ▲ Han Meilin Air China logo design manuscript

  ▲ Logo design of China International Airlines

  ▲ Han Meilin and Air China

  Since 2012, Mr. Han Meilin has been entrusted by Air China to preside over the creation and design of its brand-new aircraft interior. During the one-year design process, Mr. Han Meilin extracted the cultural heritage of China and combined traditional decorative arts with modern textile technology, which won the admiration and praise of Air China and British craft design companies. The number of data sketches collected by investigation is huge beyond imagination, and each square continuous design draft is the original large hand-painted draft with full open paper type. The connection between design drawings and making objects is one of the key points of the whole design. Textile samples are sent to Mr. Han’s studio from Britain by a famous British design company for his selection and further revision. The final interior design system shows the perfect combination of oriental aesthetic implication and craft creation.

  ▲ Han Meilin was entrusted by Air China to preside over the creation and design of its brand-new model interior.

  ▲ Design does not know national boundaries, and communication creativity is infinite.

  ▲ Han Meilin was interviewed by foreign media.

  ▲ Han Meilin’s cabin interior design manuscript

▲ Air China simulation cabin located at Han Meilin Art Museum in Beijing.

  Mr. Han graduated from the Central Academy of Arts and Crafts, which is the predecessor of Tsinghua University Academy of Fine Arts, where I now teach. He used to be the leader of art design in China. He established a complete art design education and practical creation system at that time through utilitarianism and independent innovation, and established the concept that art design serves the people’s needs, food, clothing, housing and transportation, and learned from nature, tradition and folk learning extensively. This is different from the evaluation and appreciation standard of so-called "pure art", which is a more open system pattern. Knowing this, you will understand the value of his sculpture, his purple sand, his logo and mascot design. On this road, "inheritance" is the cornerstone, and "innovation" is the driving force. Teacher Han Meilin is the vanguard of this charming art road.

  Appreciation of some designs in Han Meilin

  ▲ Logo design of Han Meilin Art Foundation.

  ▲ Volunteer logo design of Han Meilin Art Foundation

  ▲ Logo design of China literary volunteers.

  ▲ Logo design of Zhejiang Art Museum

  ▲ Logo design of National Science and Technology Communication Center

  ▲ Rong Baozhai 350th anniversary logo design.

  ▲ Logo Design of "Merrill Cup" Youth West Lake Painting Competition

  ▲ Logo design of China Golden Rooster and Hundred Flowers Film Festival

  ▲ The Third China International Cartoon & Animation Festival Logo Design

  ▲ Logo design of the first World Buddhist Forum

  ▲ Logo design of China-Russia Youth Friendly Exchange Year

  ▲ Logo design of the first leaders’ meeting of Lancang-Mekong cooperation.

  ▲ Urban Logo Design of Langfang, Hebei

  ▲ Shanxi Yuncheng City Logo Design

  ▲ Yuhang Tourism Logo Design

  ▲ Logo design of China Overseas Friendship Association

  ▲ Logo design of 2016 Tangshan World Horticultural Exposition

  ▲ Logo design of China Gymnastics Association

  ▲ Logo Design of ▲2014APEC Disabled Side Event

  ▲ Logo design of China Film Association

  ▲ Logo design of Chinese Quyi Artists Association

  ▲ Logo design of China Arts and Crafts Association

  ▲ World Water Congress logo design

  ▲ Hangzhou International Day logo design

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On canceling the "anti-routine" of the 2020 national examination questions of big composition

On November 24, 2020, the written examination for civil servants of the central organs and their directly affiliated institutions began. This is the national examination center located in Chengdu University of Information Science and Technology.

  Welcome the light snow in winter, such as the national examination. On the morning of November 24th, 2020, the written examination for civil servants of central organs and their directly affiliated institutions began. According to the official data released earlier, the national examination plans to recruit 24,000 people, involving 86 units and 23 directly affiliated institutions of the central and state organs, with a total of 1.437 million people passing the qualification examination, and the ratio of the number of qualified people to the number of employment plans is about 60: 1.

  — — This is also the 12 consecutive years, and the number of applicants for the national examination has exceeded one million.

  This is almost the exam with the highest national participation except the college entrance examination, and the overall admission rate of 1.68% is as difficult as that of Tsinghua Peking University. In Sichuan, there were 35,646 candidates in the examination area, and 28,218 actually took the examination, with a reference rate of 79.2%, which was higher than that in the national examination in 2019, but there were still 7,428 candidates who passed the qualification examination and stood up.

  Focus 1

  2315:1

  The fiercest competition for the hottest position is reduced.

  In the past three years, the national examination has experienced a ups and downs in the number of people enrolled in the plan.

  In the national examination in 2018, it is planned to recruit more than 28,000 people. In the end, 1,659,700 people passed the qualification examination, an increase of 173,400 compared with 2017, and the ratio of the number of people who passed the qualification examination to the number of employment plans was 58: 1.

  In the national examination in 2019, it is planned to recruit 14,500 people, and a total of 1,379,300 people passed the qualification examination. The average competition ratio reached 95: 1, the highest in the previous five years, and the competition for the hottest positions exceeded 4,000: 1.

  By this year, it is planned to recruit about 24,100 people, and a total of 1.437 million people have passed the registration qualification examination, and the ratio of the number of qualified people to the number of employment plans is about 60: 1.

  It can be seen that from the total number of people enrolled in the plan, although this year has greatly increased compared with the recruitment plan of more than 14,500 people last year, the ratio of 60: 1 is still fierce.

  On the other hand, the hottest position this year is the first-level chief clerk of the Reproduction Department of China No.1 Historical Archives and below. This position recruits one person, with a competition ratio of 2315: 1, but compared with the competition ratio of 9837: 1 of the hottest position in 2017, the popularity has been greatly reduced.

  In addition, a total of 19 Sichuan-related departments participated in the recruitment examination in this national examination, including Chengdu Customs, Chengdu Railway Public Security Bureau, Sichuan Supervision Bureau of the Ministry of Finance, etc. A total of 676 posts were announced and 942 people were recruited. As of one hour before the end of the registration, a total of 49,313 applicants have applied for positions in Sichuan departments, and 40,054 people have passed the trial.

  Among them, the most fierce competition is that the first three positions are tax departments. They are the first-class administrative law enforcer (1) of Leibo County Taxation Bureau in State Taxation Administration of The People’s Republic of China, the first-class administrative law enforcer (3) of jinniu district Taxation Bureau in Chengdu, State Taxation Administration of The People’s Republic of China and the first-class administrative law enforcer (2) of Leibo County Taxation Bureau in State Taxation Administration of The People’s Republic of China.

  As of one hour before the end of registration, the competition ratio has been "one thousand people vying for one job".

  Focus 2

  Examination questions "anti-routine"

  In the graded examination, the big composition was replaced.

  As an important examination for selecting talents for the country, the scientific setting of national examination questions has been constantly explored. In this year’s announcement, it was clearly pointed out in the first year that "the written examination of public subjects will make test questions for the positions of the central organs and their provincial-level directly affiliated institutions, and the positions of the municipal (prefecture) level and below directly affiliated institutions".

  "The national examination is really getting harder and harder. I feel that I can’t go to the routine, but I have to learn and accumulate. "Zhao Ling, a candidate, was a little depressed when she walked out of the examination room. This is her third year to participate in the national examination. The latest time, she was only two places away from entering the interview.

  She told reporters that in her opinion, the difficulty of the morning test was similar to that of previous years, among which the old man Zhang Fuqing, a model of the times, was admitted. But the problem of graphic reasoning is much more difficult, and I don’t know how to start at all. At the end of the last half hour, even an old hand like her felt a little flustered.

  The real "anti-routine" is the application in the afternoon. Many candidates told reporters that it was a bit awkward to hold the question. "Is the big composition gone?" “

  This year, the examination questions of prefecture-level cities involve putting forward solutions and measures for farmers’ markets, writing an introduction outline for smart communities in the district, and writing a recommendation material for local villages.

  The provincial and ministerial examination questions are related to the introduction of talents. "The topic is not new, but it is difficult to find the angle. "One candidate admitted that he had memorized the composition template and" universal golden sentence "before the exam, and the result was useless at all.

  "The main test is the overall quality and potential ability of the candidates, and they care more about a cumulative process than a surprise attack before the exam. "In response to the national examination questions, a professional who has been engaged in relevant training for a long time said that the threshold for entering the national examination is improving, and the recruitment conditions for many positions have become more stringent in different aspects. At the same time, the examination questions are constantly innovating in form. It is necessary to examine the overall quality of the applicants and play a selective role.

  Focus 3

  Don’t judge people by their differences.

  Appropriate tilt for special areas and positions

  It is worth noting that in addition to the exploration of classification and grading in written examination, the national examination is also constantly exploring the "morality" and "politics" of candidates and constantly optimizing the selection methods.

  For example, in 2011, the national examination began to sign a letter of good faith, and in 2016, efforts were intensified to crack down on cheating in the examination. In 2017, it was further clearly pointed out that the work would be further strictly inspected. This year, on the basis of previous years, the number of people who have been expelled from the Communist Party of China (CPC) Party membership and those who have been listed as joint disciplinary targets for dishonesty in accordance with the law have been specially increased, and they are not allowed to enter the examination.

  At the same time, in the inspection session, this year, it was particularly pointed out that "the inspection work highlights political standards and adopts methods such as individual talks, field visits, strict examination of personnel files, inquiry of social credit records, and personal interviews, focusing on understanding the political beliefs, political positions, political awareness and political performance of the candidates. Some recruitment agencies at the central level carry out the difference inspection, and select the best candidates according to the principle of matching people with posts, not just selecting people. “

  On the other hand, after the written examination of the national examination is finished, the central civil servant department will study and determine the minimum qualified scores for written examinations of various positions, and will appropriately tilt the positions in the western region and hard and remote areas, grassroots positions and special professional positions.

  Next, candidates can log on to the special website of examination records in January 2020 to check the written test scores and the minimum qualified scores.

  Among them, the written test scores of 8 non-common language positions are synthesized according to the proportion of 25%, 25% and 50% of the administrative professional ability test, application and foreign language proficiency test respectively. The written test scores of the special professional positions in China Banking and Insurance Regulatory Commission and its dispatched offices in China and the special professional positions in China Securities Regulatory Commission and its dispatched offices were synthesized according to the proportion of 25%, 25% and 50% of the written test scores of administrative professional ability test, application and professional subjects respectively. The positions of people’s police in public security organs are synthesized according to the proportion of 40%, 30% and 30% of the scores of administrative professional ability test, application and written examination of professional subjects respectively.

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National Health Commission: The mortality rate in novel coronavirus, China is 2.1%.

  China news agency, Beijing, February 4 (Reporter Li Yanan) The National Health and Wellness Committee of China held a press conference on the 4 th to further strengthen the medical treatment of severe pneumonia patients infected by novel coronavirus. Jiao Yahui, deputy director of National Health Commission Medical Administration and Hospital Authority, said that as of 24: 00 on February 3, the mortality rate of pneumonia infected by novel coronavirus in China was 2.1%.

  "According to the fatality rate of confirmed cases, as of 24: 00 yesterday, the cumulative number of confirmed cases of pneumonia in novel coronavirus was 20,438, and the cumulative death was 425. According to this figure, the national mortality rate, that is, the mortality rate of confirmed cases is 2.1%. " Jiao Yahui introduced that the death patients were mainly concentrated in Hubei Province, with a total of 414 people, accounting for 97% of the country. The mortality rate of confirmed cases in Hubei Province was 3.1%.

  "In addition, the death toll in Wuhan is 313, accounting for 74% of the national death toll, and the mortality rate in Wuhan is 4.9%. The mortality rates in Hubei Province and Wuhan City are higher than the national level. If the mortality rate in other provinces except Hubei Province is removed, it is 0.16%." Jiao Yahui said that from this set of figures, we can see that the main deaths are still in Hubei, mainly concentrated in Wuhan. For other provinces in the country, although there are many cases, the mortality rate is actually quite low.

  "From this point of view, we are still confident. Most of our cases are still light cases, so there is no need to panic." She said.

  Jiao Yahui pointed out that the national mortality rate is basically stable, now it is 2.1%, and it was 2.3% at the beginning of the epidemic, which can be said to be a slight decline. According to the analysis of the death cases, the majority of them are men (2/3) and women (1/3), and most of them are elderly. More than 80% of them are elderly people over 60 years old, and more than 75% of them have one or more basic diseases, and these basic diseases are cardiovascular and cerebrovascular diseases, diabetes, and some patients have basic diseases such as tumors.

  Jiao Yahui said that for the elderly who are old and have basic diseases, as long as they are infected with pneumonia, it is a high-risk factor in clinic, and the mortality rate itself is very high, not because they are infected with pneumonia in novel coronavirus.

  When talking about the current situation that the mortality rate in Wuhan is significantly higher than that in other provinces in China, Jiao Yahui analyzed that the severe patients in the early stage were mainly admitted to three designated hospitals, and the capacity of these three designated hospitals was far from enough. Other critically ill patients are scattered in more than 20 medical institutions, and the principle of "four concentrations" has not been fully implemented. These patients are scattered, which is not conducive to management. In addition, they are not managed by medical teams specializing in critical medicine, so the strength of high-quality medical resources is diluted to some extent, which is also a factor leading to a high mortality rate of critically ill patients.

  She introduced that now, an independent hospital area of a third-class general hospital has been newly recruited as a designated hospital for treating critically ill patients, and a team of academicians has been organized to make rounds, and a national high-level hospital has been organized to take over the management of critically ill patients in these hospitals, and a series of systems have been established, including the patrol system of academicians, the multidisciplinary comprehensive treatment system and the holistic nursing system.

  "At the same time, we have to do a good job in the rotation of medical staff, especially in the diagnosis and management of severe patients. The ratio of human resources needed is more than that of mild patients and ordinary patients, and the work intensity is very high, so it is necessary to increase the rotation, because it is also a very important measure to ensure the physical and mental health of medical staff. We hope that by adopting these comprehensive measures, we can exert the effect as soon as possible. I believe that it will not take long for this effect to appear, and the mortality rate in Wuhan should gradually decline. " Jiao Yahui said. (End)